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Sulfonylureas

Expert opinion editorial

The CAROLINA trial: Make or break for sulfonylureas?

Sulfonylurea pill

Diabetologist Sanjay Kalra puts the CAROLINA trial into historical context and considers the present-day implications for the use of DPP-4 inhibitors and sulfonylureas. 

Get more on: Sulfonylureas | DPP-4 inhibitors | Other diabetes medications

medwireNews editor's pick

Poor availability, affordability compromise global diabetes medication use

Global health

Diabetes medications are frequently unavailable and unaffordable, particularly in lower-income countries, shows an analysis of the PURE study.

medwireNews editor's pick

Continuing metformin advisable for patients starting sulfonylurea treatment

Metformin formula

Research shows that starting second-line sulfonylurea treatment is associated with an increased risk for cardiovascular and hypoglycemic events among patients with type 2 diabetes in clinical practice, although the risk is less if they continue using metformin rather than switching completely.

medwireNews editor's pick

Reassuring long-term data for sulfonylurea in neonatal diabetes

Newborn baby

Sulfonylurea treatment is durably effective with a low rate of side effects in patients with permanent neonatal diabetes caused by mutations in the KCNJ11 gene, a study in The Lancet Diabetes & Endocrinology shows.

medwireNews editor's pick

Glyburide ‘not justified’ as first-line gestational diabetes treatment

Diabetes and pregnancy_AdobeStock_158940533

A head-to-head trial in women with gestational diabetes has failed to prove that glyburide is statistically noninferior to insulin in terms of perinatal outcomes.

Journal article

Clinical management of women with monogenic diabetes during pregnancy

Clinical management of women with monogenic diabetes during pregnancy

Here, we will review the pathophysiology of the common forms of monogenic diabetes and recent evidence and recommendations for management during pregnancy [Read more].
Dickens LT, Naylor RN. Curr Diab Rep 2018; 18: 12. doi: 10.1007/s11892-018-0982-8

Get more on: Monogenic diabetes | Diabetes in pregnancySulfonylureas 

Expert opinion editorial

Does setting treatment targets risk the overtreatment of type 2 diabetes in older patients?

Pill in hand (symbolic image with model)

The drive to achieve lower HbA1c targets in older patients is not without concern or risk. Our UK Board address concerns highlighted by recent trials and discuss whether current guidelines do enough to mitigate the risks of overtreatment [read more].

Get more on: Medication | Older adults |  Type 2 diabetes

medwireNews

07-15-2019 | Medications | News

Second-line type 2 diabetes therapies vary globally

Second-line therapy choices for people with type 2 diabetes vary widely throughout the world and are influenced not only by clinical characteristics but also non-medical factors such as affordability and availability, results from the DISCOVER study show.

06-11-2019 | Linagliptin | ADA 2019 | News

CAROLINA shows neutral cardiovascular profile for modern sulfonylurea

The dipeptidyl peptidase-4 inhibitor linagliptin and the sulfonylurea glimepiride have similar cardiovascular safety profiles, show the results of the CAROLINA trial.

03-14-2019 | Hypoglycemia | News

Real-world hypoglycemia data support continued sulfonylurea role in type 2 diabetes

Hypoglycemia is common among people being treated for type 2 diabetes, particularly those using insulin or a sulfonylurea, but the risk for severe episodes is only elevated among insulin users, suggest results of a prospective UK study.

Themed collections

05-22-2017 | Heart failure | Themed collection | Collection

Heart failure and diabetes mellitus

This collection provides an overview of the epidemiology, underlying pathophysiological mechanisms, screening, assessment and management of heart failure in patients with diabetes mellitus.

Journal articles and book chapters

06-22-2018 | Monogenic diabetes | Review | Article

Advances in the genetics of youth-onset type 2 diabetes

Todd JN, Srinivasan S, Pollin TI. Curr Diab Rep 2018; 18: 57. doi: 10.1007/s11892-018-1025-1

Guidelines

A convenient single access point, providing diabetes professionals with links to a comprehensive set of clinical practice guidelines from a wide range of relevant organizations.

Slides

Downloadable PowerPoint slide sets containing a variety of high-quality images and illustrations from Springer Nature’s library of published figures.

Practice tips

Practical information, guidance, and helpful resources for diabetes healthcare providers. Comprised of practical approaches, case studies, and more.

Themed collections

Compendia of selected, recently published, free full-text journal and book content from Springer Nature and other publishers on a particular topic within diabetes management, as recommended by our Editorial Board.

Independent Medical Education

Educational programs building upon the most current research and professional practice recommendations, with the aim of enabling more efficient diagnosis, optimizing treatment, and improving patient outcomes.

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