The primary findings
The ground-breaking Diabetes Remission Clinical Trial (DiRECT) showed for the first time that substantial weight loss achieved with diet alone in a primary care setting could reverse type 2 diabetes.
News | 4-min read
DiRECT: Diabetes remission achievable in primary care
Nearly half of the patients helped to follow a very-low-calorie diet for at least 3 months achieved and maintained remission of type 2 diabetes over the 12 months of the DiRECT intervention, the investigators report.
The 2-year outcomes
The DiRECT investigators followed up the study participants to assess how many remained in remission.
How does the intervention work in routine practice and outside of the UK?
Latest reporting on DiRECT
More research findings from the DiRECT, including mechanisms and cost-effectiveness.
09-09-2020 | Diet | News
Weight loss strongest predictor of remission in DiRECT
The strongest predictor of type 2 diabetes remission is weight loss, with other variables only modestly associated with outcome and insufficient to identify people unsuitable for attempting this goal, shows a post-hoc analysis of DiRECT data.
06-19-2019 | Diet | ADA 2019 | News
DiRECT: Beta cells ‘not dead’ in type 2 diabetes
People who achieved sustained remission of type 2 diabetes via substantial weight loss in the DiRECT trial regained normal maximal beta-cell capacity, the investigators report.
03-20-2018 | Diet | News
DiRECT: Effects on insulin and liver fat revealed
Researchers from the DiRECT trial have reported large positive effects on liver fat and insulin secretion among people who achieved type 2 diabetes remission in response to a very-low-calorie diet.
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DiRECT trial, Young woman losing weight/© atakan / Getty Images / iStock, Feet on weighing scales, Roy Taylor/© Newcastle University, UK, John Wilding, Amar Puttanna, Alison Barnes