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Oral combination medications 

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  1. 08-09-2022 | Liraglutide (T2DM) | At a glance | Article

    A quick guide to the LEAD trials

    LEAD-4: Published Trial population: People with type 2 diabetes taking one or more oral antidiabetic medications Comparator treatment: Placebo NCT00333151 As detailed i n Diabetes Care , all participants in LEAD-4 were started on metformin or rosiglitazone (any other medications were discontinued), to which was added liraglutide or placebo.

  2. 05-20-2022 | Immunotherapy | Hot topic review | Article

    How far has immunotherapy for type 1 diabetes progressed?

    However, the combination treatment had no effect on C-peptide decline.

  3. 07-01-2021 | ADA 2021 | News | Article

    Use of glucose-lowering medications remains suboptimal in people with type 2 diabetes

    At baseline, 10.8% started treatment on either an SGLT2 inhibitor (8.7%), a GLP-1 receptor agonist (2.1%), or a combination of both (0.1%) as second-line therapy.

  4. 03-15-2022 | Hypoglycemia | News | Article

    Severe hypoglycemia risk factors identified in insulin users with type 2 diabetes

    Individuals currently using non-insulin glucose-lowering medications also had a significantly lower risk for severe hypoglycemia relative to people not taking these drugs, at an OR of 0.81.

  5. 12-14-2017 | Guidelines | Editorial | Article

    What is new in the 2018 American Diabetes Association Standards of Medical Care in Diabetes?

    As with all medications, drug-specific and patient factors should be considered. 

  6. 08-28-2018 | Oral combination medications | Article

    Efficacy and safety of initial combination therapy in treatment-naïve type 2 diabetes patients: A systematic review and meta-analysis

    The aim of this study was to evaluate the efficacy and safety of initial combination therapy compared with monotherapy in drug-naïve type 2 diabetes

  7. 08-26-2018 | Oral combination medications | Article

    Mechanistic insights from sequential combination therapy with an SGLT2 inhibitor and DPP‐IV inhibitor: Results from the CANARIS trial using canagliflozin and teneligliptin

    Okahata S et al. Diabetes Obes Metab 2018. doi: 10.1111/dom.13505

  8. 06-13-2018 | Oral combination medications | Article

    A randomized controlled trial of dapagliflozin plus once-weekly exenatide versus placebo in individuals with obesity and without diabetes: Metabolic effects and markers associated with bodyweight loss

    Pereira MJ et al. Diabetes Ther 2018. doi: 10.1007/s13300-018-0449-6

  9. 05-25-2018 | Oral combination medications | Article

    Characterization of the open-label lead-in period of two randomized controlled phase 3 trials evaluating dapagliflozin, saxagliptin, and metformin in type 2 diabetes

    Mathieu C et al. Diabetes Ther 2018. doi: 10.1007/s13300-018-0445-x

  10. 12-08-2021 | Empagliflozin | News | Article

    Empagliflozin beneficial in HFrEF regardless of existing treatment

    Empagliflozin decreases the risk for serious outcomes in people with heart failure with reduced ejection fraction irrespective of which medications they were already taking and at what intensity, suggests a post-hoc EMPEROR-Reduced analysis.

  11. 05-18-2018 | Type 2 diabetes | Review | Article

    Combination glucose-lowering therapy plans in T2DM: Case-based considerations

    Blonde L, Dipp S, Cadena D. Adv Ther 2018. doi: 10.1007/s12325-018-0694-0

  12. 04-05-2018 | Oral combination medications | Review | Article

    Combination treatment of SGLT2 inhibitors and GLP-1 receptor agonists: Symbiotic effects on metabolism and cardiorenal risk

    Goncalves E, Bell DSH. Diabetes Ther 2018; 9: 919–926. doi: 10.1007/s13300-018-0420-6

  13. 03-23-2018 | Oral combination medications | Article

    SGLT2 inhibitor plus DPP‐4 inhibitor as combination therapy for type 2 diabetes: A systematic review and meta‐analysis

    Li D et al.  Diabetes Obes Metab 2018; Advance online publication. doi: 10.1111/dom.13294

  14. 09-07-2021 | Nephropathy | Ask the expert | Article

    DKD treatment update: SGLT2 inhibitors and finerenone

    It is a high risk combination of presentations that requires care, and if it's not done in primary care, people won't be treated.

  15. 12-15-2016 | Guidelines | Editorial | Article

    What is new in the 2017 American Diabetes Association Standards of Care?

    Long-term safety data are not available for any oral agent.

  16. 02-03-2017 | Medications | Review | Article

    Early combination therapy with oral glucose-lowering agents in type 2 diabetes

    Bianchi C et al. Drugs 2017; 77: 247–264. doi: 10.1007/s40265-017-0694-4

  17. 06-16-2018 | Cardiovascular disorders | Review | Article

    Inpatient glycemic management of non-cardiac CVD: Focus on stroke and PVD

    Metformin and other non-insulin glucose-lowering medications should be held the morning of surgery.

  18. 02-19-2016 | Hyperglycemic hyperosmolar state | Review | Article

    Diabetic emergencies: Ketoacidosis, hyperglycemic hyperosmolar state, and hypoglycemia

    Insulin therapy and insulin secretogogues were identified as the medications most frequently associated with hypoglycaemia.

  19. 03-13-2019 | Canagliflozin | News | Article

    ABCD audit data reveal improved glycemic control with use of FreeStyle Libre, canagliflozin

    The findings were presented during an oral session at the 2019 Diabetes UK Professional Conference in Liverpool .

  20. 06-13-2017 | Hypoglycemia | Editorial | Article

    Is it harder to treat diabetes today?

    Most people ended up on all three oral medications, so order was less important.

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