Diabetes complications and comorbidities in specific populations

Impaired hypoglycemia awareness is present in a substantial proportion of children and young people with type 1 diabetes and is associated with an increased risk for severe hypoglycemia, suggests research presented at the virtual 57th EASD Annual Meeting.

Factors including insulin use and ethnicity can help predict who will develop proliferative diabetic retinopathy within 5 years after type 2 diabetes diagnosis, say researchers.

A large systematic review and meta-analysis has identified racial/ethnic differences in the risk for complications and all-cause mortality among people with diabetes.

Using a linear insulin to carbohydrate ratio to determine breakfast insulin requirements leads to significant differences in time in glycemic range and hypoglycemia rates when meal carbohydrate quantities vary, shows a study in children and young adults.

Assessing executive function and screening for disordered eating behaviors could help identify teenagers with type 1 diabetes who will benefit from interventions aimed at improving long-term outcomes, researchers report in Diabetic Medicine.

The risk for diabetes-related complications increases over time among people with youth-onset type 2 diabetes, with the majority having at least one microvascular complication by the time of young adulthood, suggest follow-up results from the TODAY study.

The presence of an eating disorder diagnosis significantly increases the risk for diabetic ketoacidosis and all-cause mortality in adolescents and young adults with type 1 diabetes, shows a population-based study.

Researchers find diminished cardiovascular gains and an increased risk for severe hypoglycemia in frail people with type 2 diabetes given intensive glycemic and blood pressure treatment.

Dasiglucagon, a next-generation glucagon analog in a ready-to-use formulation, rapidly restores plasma glucose levels following severe hypoglycemia in children and adolescents with type 1 diabetes, show findings from a phase 3 trial.

Fear of hypoglycemia, rather than the actual frequency of hypoglycemic events, may impact diabetes-specific quality of life in adolescents, say researchers.

Analysis of older participants in the BRIGHT trial suggests that this subgroup may do slightly better with insulin glargine-300 than with degludec.

The use of continuous glucose monitoring does not increase time in range in young children with type 1 diabetes, but may improve other glycemic indices, researchers report.

Acute kidney injury is common in children with diabetic ketoacidosis and is associated with circulatory volume depletion, greater acidosis, and signs of cerebral injury, US study data show.

Cardiovascular event rates do not differ significantly among people with type 2 diabetes treated with linagliptin or glimepiride regardless of age, but those who receive linagliptin have lower risks for falls and hypoglycemia, CAROLINA trial data show.

Results from an observational study suggest that the use of metformin in older patients with type 2 diabetes is associated with a reduced decline in both global cognition and executive function, and a decreased risk for dementia.

Research shows moderate or severe diabetic ketoacidosis is associated with lower IQ and reduced short- and long-term memory in children with type 1 diabetes, with some impairment seen even in newly diagnosed children.

Study findings presented at the virtual 56th EASD Annual Meeting indicate that polypharmacy is common among people with type 1 diabetes and is associated with an increased risk for adverse outcomes.

Youth with type 2 diabetes have lower areal bone mineral density than those with obesity or who are of normal weight, according to the results of a cross-sectional study.

Severe hypoglycemia in people with type 2 diabetes is associated with later mortality from a wide range of causes, including those for which there is no obvious underlying mechanism, say researchers.

Researchers have identified a marked increase in the proportion of children and adolescents who have diabetic ketoacidosis at the point of type 1 diabetes diagnosis during the COVID-19 pandemic.