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Monogenic diabetes

06-08-2022 | ADA 2022 | Conference coverage | News

First-in-class glucokinase activator dorzagliatin could help treat some GK-MODY patients

Dorzagliatin treatment has increased insulin secretion and improved beta-cell function in patients with glucokinase maturity-onset diabetes of the young, also known as MODY2, in a small phase 1 trial.

06-07-2022 | ADA 2022 | Conference coverage | News

Case series suggests SGLT2 inhibitors could be useful add-on therapy for MODY3

Results from a small case series in Denmark suggest SGLT2 inhibitors could be a useful add-on therapy for people with maturity-onset diabetes of the young.

11-08-2021 | Genetics | News

Novel diabetes gene identified

Mutations in the ONECUT1 gene can underlie neonatal diabetes and contribute to the risk for early-onset type 2 diabetes, research shows.

06-26-2021 | ADA 2021 | Conference coverage | News

Genetic influence stronger for youth- than adult-onset type 2 diabetes

The effect of common genetic variants on the risk for type 2 diabetes is markedly stronger for youth-onset than adult-onset disease, report researchers.

09-24-2020 | EASD 2020 | Conference coverage | News

GLIMLINA: Glimepiride–linagliptin combination shows potential for HNF1A-MODY

Adding linagliptin to glimepiride treatment reduces some measures of glycemic variability and improves glycemic control in patients with HNF1A-MODY, indicate findings from the GLIMLINA trial.

11-14-2019 | MODY | News

Islet autoantibody negativity, mild hyperglycemia should trigger MODY genetic screening

Islet autoantibody negativity plus mild hyperglycemia and a family history of diabetes can be used to identify children newly diagnosed with diabetes who should undergo genetic testing for maturity-onset diabetes of the young, study findings indicate.

07-29-2019 | Pathophysiology | News

Cluster analysis may help to predict diabetic complications

Allocating people with diabetes to one of five previously described data-driven clusters may help to identify those at high immediate risk for developing diabetic neuropathy or non-alcoholic fatty liver disease, say researchers.

06-08-2019 | Monogenic diabetes | ADA 2019 | News

Monogenic diabetes mutations prevalent in type 2 diabetes

People with type 2 diabetes have a high prevalence of pathogenic mutations in genes typically associated with monogenic diabetes.

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