Pathophysiology

Research published in Nature Medicine shows how the specific characteristics of people with type 2 diabetes could one day guide disease management.

Tirzepatide improves glucose control more than semaglutide in people with type 2 diabetes by improving beta-cell function as well as boosting insulin sensitivity and reducing glucagon secretion, shows a randomized trial.

Hyperinsulinemic hypoglycemia is associated with an increase in left ventricular ejection fraction among people with type 1 diabetes and healthy controls, research suggests.

Children with familial type 1 diabetes have different characteristics to those with sporadic diabetes at presentation, but longer-term outcomes are similar, say researchers.

Black West African men have lower levels of insulin secretion in response to a meal than their White Northern European counterparts, irrespective of insulin sensitivity, study findings indicate.

Sustained remission of type 2 diabetes in DiRECT was accompanied by normalization of pancreatic morphology, say the researchers.

Levels of circulating C-peptide in people with type 1 diabetes reflect the numbers of remaining beta cells across different ages at diagnosis and durations of disease, confirm UK researchers.

Early-phase hyperglucagonemia in response to ingesting a meal is associated with postprandial glucose excursions in patients with type 1 diabetes, research suggests.