Pediatric type 1 diabetes

Findings from the SEARCH for Diabetes in Youth study suggest that diastolic dysfunction is prevalent among young adults with type 1 or type 2 diabetes, but those with type 2 diabetes have the highest risk.

The Omnipod Horizon closed-loop system has delivered good glucose control in its first outpatient study, the investigators report.

The Youth Empowerment Skills program, a novel psychoeducational intervention for adolescents and young adults with type 1 diabetes, may help to improve glycemic control and reduce acute diabetes emergencies in this challenging group of patients, research shows.

The Medtronic MiniMed Advanced Hybrid Closed-Loop system delivers better glycemic control than the currently approved 670G system, shows the international FLAIR trial.

Beta-cell function enters a period of rapid decline around 6 months before people meet the diagnostic threshold for type 1 diabetes, show TrialNet data.

Asymptomatic celiac disease is a frequently occurring comorbidity in people with type 1 diabetes, and transitioning to a gluten-free diet may increase postprandial glycemic variability, researchers report.

Findings from the EDITION JUNIOR trial indicate that glargine-300 and glargine-100 have similar efficacy and safety when used with mealtime insulin in children and adolescents with type 1 diabetes.

A major study of children from three continents suggests that diabetic ketoacidosis remains unacceptably high among those newly identified with type 1 diabetes and shows few signs of improving.

Age at type 1 diabetes diagnosis does not appear to affect glycemic control and comorbidity once disease is established, but important differences occur between age groups at the time of diagnosis, US study data show.

A survey of US adolescents with type 1 diabetes has found that cost, negative attitudes towards wearing a device, and technology-related anxiety all act as obstacles preventing the use of devices in this age group.

Researchers provide further evidence to support two distinct type 1 diabetes endotypes characterized by a more or less aggressive autoimmune response and a younger or older age at onset.

The presence of diabetes distress and body dissatisfaction may warn of a high risk for disordered eating in adolescents with type 1 diabetes, show data from the Diabetes MILES Youth–Australia study.

A high BMI may contribute to the risk for progressing from single to multiple islet autoantibodies, especially in children who would otherwise be at relatively low risk, show findings from TrialNet.

Healthcare professionals can make false assumptions about which children with type 1 diabetes will gain most from closed-loop insulin delivery, risking children who could potentially benefit missing out, research suggests.

Children born to mothers with diabetes and severe obesity have an elevated risk for developing neuropsychiatric disorders, researchers report.

Around one in 300 children aged 2–5 years from the general population may be positive for islet autoantibodies on screening and therefore have presymptomatic type 1 diabetes, results of the Fr1da study suggest.

Researchers uncover geographic heterogeneity in type 1 diabetes incidence across England, and identify demographic and environmental factors significantly associated with this variability.

People who die in young adulthood from acute complications of type 1 diabetes are characterized by poor glycemic control during childhood, report Swedish researchers.

Children with type 1 diabetes have increased activation of certain areas of the brain during attention-demanding tasks, which may compensate for diabetes-related impairments and bring their cognitive ability in line with peers without diabetes, report researchers.

The setting in which children with newly diagnosed type 1 diabetes initiate their care makes no significant difference to glucose control, psychologic outcomes, or the rate of adverse events, shows a UK study comparing home and hospital options.