Pediatric type 1 diabetes

Dasiglucagon, a next-generation glucagon analog in a ready-to-use formulation, rapidly restores plasma glucose levels following severe hypoglycemia in children and adolescents with type 1 diabetes, show findings from a phase 3 trial.

Children with familial type 1 diabetes have different characteristics to those with sporadic diabetes at presentation, but longer-term outcomes are similar, say researchers.

Fear of hypoglycemia, rather than the actual frequency of hypoglycemic events, may impact diabetes-specific quality of life in adolescents, say researchers.

Routine psychosocial screening of adolescents with type 1 diabetes uncovers a sizable proportion who could benefit from additional support, say researchers.

Young adults with diabetes type 1 show improvements in clinic attendance rates when a nonmedical transition coordinator is present during the changeover from pediatric to adult diabetes care, say the authors of a Canadian clinical trial.

Adolescents with type 1 diabetes who are obese have a cardiorenal risk profile similar to that of their peers with type 2 diabetes, say researchers.

The use of continuous glucose monitoring does not increase time in range in young children with type 1 diabetes, but may improve other glycemic indices, researchers report.

Acute kidney injury is common in children with diabetic ketoacidosis and is associated with circulatory volume depletion, greater acidosis, and signs of cerebral injury, US study data show.

Starting children on an insulin pump within 6 months of type 1 diabetes diagnosis is associated with improved outcomes relative to delaying for 2 or 3 years, shows an analysis of data from the DPV registry.

Children with type 1 diabetes make more consistent use of continuous glucose monitoring if they are given the device when they initiate insulin pump therapy, rather than several months later, show the CGM TIME Trial results.

Researchers have identified infants as young as 3 months with probable type 1 diabetes, raising the possibility that the disease process could in some cases begin before birth.

Research shows moderate or severe diabetic ketoacidosis is associated with lower IQ and reduced short- and long-term memory in children with type 1 diabetes, with some impairment seen even in newly diagnosed children.

Levels of circulating C-peptide in people with type 1 diabetes reflect the numbers of remaining beta cells across different ages at diagnosis and durations of disease, confirm UK researchers.

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Children with type 1 diabetes who use the Tandem Control-IQ hybrid closed-loop insulin delivery system spend more time with their blood glucose levels in the target range than those using a sensor-augmented insulin pump, show findings from the iDCL trial.

Children and adolescents with type 1 diabetes become more diligent about bolusing for insulin at mealtimes in the run-up to a clinic appointment, as reflected in objective data from their insulin pumps.

Involving older children with type 1 diabetes in the decision-making process about starting continuous glucose monitoring may help to ensure that they persist with the technology, report researchers.

Researchers have identified a marked increase in the proportion of children and adolescents who have diabetic ketoacidosis at the point of type 1 diabetes diagnosis during the COVID-19 pandemic.

Continuous glucose monitoring is well accepted and reduces time in hypoglycemia among older individuals with type 1 diabetes, report researchers in JAMA.

Glycemic control in youth and young adults with diabetes has not improved with time, and in some cases has worsened, despite more aggressive glycemic targets and increased availability of newer diabetes technology and therapies, shows the SEARCH for Diabetes in Youth Study.