Pediatric diabetes and hypoglycemia

Continuous subcutaneous insulin infusion therapy significantly lowers glycated hemoglobin levels in young people with type 1 diabetes, but at the cost of an increased risk for diabetic ketoacidosis during the first year, UK researchers report.

Prepubertal children with type 1 diabetes have greater glycemic variability than those who are pubertal or postpubertal, researchers have reported at the ADA’s 78th Scientific Sessions.

Neither the rate of administration nor the sodium chloride content of replacement fluids given to children with diabetic ketoacidosis influences their neurologic outcomes, show the results of the PECARN DKA FLUID Study.

Children are less likely to present with diabetic ketoacidosis at the time of type 1 diabetes diagnosis if they previously had regular access to a healthcare provider, research published in CMAJ suggests.

Research shows that intervening to improve the diet quality of adolescents with type 1 diabetes does not exacerbate disordered eating behavior.

Taking a weight-based dose of glucose resolves hypoglycemia more effectively than taking a standard fixed dose for type 1 diabetes patients using an insulin pump, show the results of a randomized crossover trial.

The risk of having a repeat episode of severe hypoglycemia is elevated for at least 4 years after a previous episode in children with type 1 diabetes, although the risk is highest during the first year, researchers report.

Children and adolescents with type 1 diabetes using a predictive low-glucose management system have less hypoglycemia and fewer hypoglycemic events than those managed using sensor-augmented pump therapy alone, according to a 6-month trial.

Findings from a population-based study indicate that insulin pump use is associated with reduced risks for severe hypoglycemia and diabetic ketoacidosis in children, adolescents, and young adults with type 1 diabetes.

A study has found that children with diabetic ketoacidosis at the diagnosis of type 1 diabetes have poor long-term glycemic control, independent of established demographic and socioeconomic risk factors.

Research suggests that a predictive low-glucose management system significantly reduces hypoglycemic events in children and adolescents with type 1 diabetes.

Almost two-thirds of children hospitalized with diabetic ketoacidosis develop acute kidney injury within 24 hours of hospitalization, study findings indicate.

Researchers report two cases of children with severe and irreversible neurologic damage caused by complications at the time of neonatal diabetes diagnosis, highlighting the need for increased awareness of the condition.

Mortality rates are high among adolescents and young adults with type I diabetes, with more than half caused by acute or chronic complications, researchers report.