medwireNews: The ASK study findings show that around 1% of children in the general population are at high risk for diabetes, and the majority of these have no family history of the condition.
At the time of reporting, at the ADA’s 78th Scientific Sessions in Orlando, Florida, the project had screened 9511 children aged between 1.0 and 17.9 years; its eventual goal is to screen 15,000. In contrast with TrialNet, which screens only children with a family history of diabetes, ASK screens children from the general population; 90.9% of those screened so far have no first-degree relative with type 1 diabetes or with celiac disease, for which the researchers are also testing.
In total, 1.1% of screened children were positive for multiple anti-islet antibodies or for one autoantibody using two different assays. And 2.0% were positive for celiac disease on two different assays. For both conditions, the likelihood of having autoantibodies was much higher for White than Hispanic children, which presenter Cristy Geno Rasmussen (Barbara Davis Center for Diabetes, Aurora, Colorado, USA) said reflects the prevalence of the conditions in these ethnic groups.
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