Advances in Closed-Loop Insulin Delivery Systems in Patients with Type 1 Diabetes
- Current Diabetes Reports
Authors: Vikash Dadlani, Jordan E. Pinsker, Eyal Dassau, Yogish C. Kudva
Publisher: Springer US
Purpose of Review
To provide a current review of closed-loop insulin delivery or artificial pancreas (AP) as therapy for people with type 1 diabetes mellitus (T1D)
The Medtronic Minimed 670G AP system has been in use in clinical practice since March 2017. Currently, Medtronic is conducting a large randomized clinical trial to evaluate its efficacy further in T1D. Simultaneously, the NIH has funded four research consortia to accelerate progress to approval of other AP and decision support systems. Several research groups are currently developing next-generation AP systems, with a number of companies moving toward releasing closed-loop systems in the future. AP systems are also being tested in select populations such as hypoglycemia-unaware T1D and pregnant T1D.
AP research is rapidly advancing. The clinical range of AP will be expanded in the next decade.