08-22-2018 | Hypoglycemia | Article
Male Patients with Longstanding Type 2 Diabetes Have a Higher Incidence of Hypoglycemia Compared with Female Patients
Journal: Diabetes Therapy
Authors: Feng-fei Li, Ying Zhang, Wen-li Zhang, Xiao-mei Liu, Mao-yuan Chen, Yi-xuan Sun, Xiao-fei Su, Jin-dan Wu, Lei Ye, Jian-hua Ma
Publisher: Springer Healthcare
Abstract
Introduction
To explore whether there was a gender difference in the risk of hypoglycemia during intensive insulin therapy in patients with longstanding type 2 diabetes (T2D). This was a post hoc analysis of a single-center, open-label and prospective trial.
Methods
All subjects were admitted as inpatients, underwent a standard bread meal test at baseline and received a 7-day continuous subcutaneous insulin infusion (CSII) therapy for achieving glycemic control. Patients then were randomized 1:1 to two groups receiving (1) 4 days of Novo Mix 30 followed by 2 days of Humalog Mix 50; (2) 4 days of Humalog Mix 50 followed by 2 days of Novo Mix 30. All patients were subjected to 4-day retrospective continuous glucose monitoring (CGM) during the last 4 days in this study. The primary outcome was the incidences of hypoglycemia monitored by CGM at the end point.
Results
A total of 102 patients met the inclusion criteria and completed the study. Our data revealed that 29 patients (28%) experienced hypoglycemia as detected by CGM at the end point. Binary logistic stepwise regression analysis showed that only gender significantly correlated with hypoglycemia (B = 1.17, p = 0.017). Importantly, male patients had a significantly higher incidence of hypoglycemia than female patients (male = 20/52, female = 9/50, p = 0.022), although male patients required significantly lower insulin doses to maintain glycemic control than female patient (p = 0.00).
Conclusion
Male patients with longstanding T2D had a higher incidence of hypoglycemia than female patients during intensive insulin therapy.
Trial registration
ClinicalTrials.gov identifier, ChiCTR-IPR-15007340.