Diabetes complications and comorbidities in specific populations

Data from the DPV cohort show a reduced risk for severe hypoglycemia and diabetic ketoacidosis among children and young people with type 1 diabetes using continuous glucose monitoring rather than self-monitored blood glucose.

Hypertension has the largest impact on mortality risk in younger people with type 2 diabetes, whereas chronic kidney disease is a greater threat for older people, shows a population-based study.

Analysis of participants in the ORACL trial leads researchers to suggest that nonfrail older adults with type 1 diabetes are better off following time in range guidance aimed at younger people.

Analysis of childhood type 1 diabetes diagnoses across 13 countries indicates that the conditions created by the COVID-19 pandemic worsened pre-existing increasing trends in ketoacidosis at diagnosis.

Women with type 1 diabetes who have microalbuminuria at the time of pregnancy have an increased risk for adverse pregnancy outcomes in the short term and for diabetes complications in the long term, shows research.

Reducing the cutoffs of commonly used depression screening measures may increase the sensitivity for detecting depression in adolescents with type 1 diabetes, US study findings indicate.

Children and adolescents using an advanced hybrid closed-loop system for type 1 diabetes can tolerate an unannounced snack containing 20 g of carbohydrate without excessive blood sugar fluctuations, Italian researchers report.

The iLet bionic pancreas closed-loop insulin delivery system provides good glucose control without the need for the user to count carbohydrates, show findings from the pivotal trial.

The risk for major leg amputation or death after hospitalization for diabetic foot ulcers is elevated in Black people and those living in rural areas, with a 10.4% absolute increase among patients with both risk factors compared with the national rate, US researchers have found.

Children born to mothers with autoimmune diseases have an elevated risk for mental disorders, with this risk persisting until early adulthood for those born to women with type 1 diabetes or rheumatoid arthritis, researchers report.

Follow-up results from the WISDM trial show that extended use of continuous glucose monitoring leads to reduced hypoglycemia without increasing hyperglycemia risk in older people with type 1 diabetes.

The Patient Health Questionnaire-9, which screens for depressive symptoms, underestimates suicide risk in adolescents and young adults with type 1 diabetes when compared with a validated suicide-specific measure, research shows.

Older adults with a longer duration of type 1 diabetes have an increased likelihood of experiencing depression and hypoglycemia unawareness, researchers report.

Almost all diabetes-related deaths in people younger than 25 years occur in countries that fall in the lower end of the Socio-demographic Index, report the GBD 2019 Diabetes Mortality Collaborators.

Among pregnant women with preexisting diabetes, those with nephropathy or retinopathy may be at increased risk for pregnancy complications, suggest findings from a systematic review and meta-analysis.

Diabetic ketoacidosis affects around one in 60 pregnant women with type 1 diabetes and is associated with “exceptionally high” perinatal mortality rates, shows research.

Young people with type 1 diabetes are at increased risk for hospitalization for acute complications at the time of transition from pediatric to adult care, say researchers.

Intensification of diabetes medications in older adults at the point of discharge from hospital is associated with an increased risk for hypoglycemia, without gains in glycemic control, research suggests.

Almost half of people diagnosed with type 2 diabetes in childhood develop retinopathy by their mid-20s, show TODAY2 data.

African–Caribbean ethnicity may be a predisposing factor for sight-threatening diabetic retinopathy in people with type 1 diabetes, research suggests.