Biguanides (metformin)

People with type 2 diabetes who maintain low glycated haemoglobin levels have slower progression of frailty over time than those with higher levels, shows an analysis of Look AHEAD participants.

Metformin use is associated with a significant reduction in the risk for total knee or hip replacement among people with type 2 diabetes, shows research published in CMAJ.

People aged 60 years or older receiving thiazolidinedione monotherapy for type 2 diabetes may have a lower risk for dementia than those taking metformin monotherapy, an observational study suggests.

The authors of a modeling study say that the price of SGLT2 inhibitors and GLP-1 receptor agonists would need to fall “by at least 70%” for them to be cost effective as first-line treatments in the USA.

van Weelden W et al. Diabetes Ther 2018. doi: 10.1007/s13300-018-0479-0

Cai X et al. Diabetes Ther 2018. doi: 10.1007/s13300-018-0493-2

Wang W et al. Diabetes Obes Metab 2018. doi: 10.1111/dom.13506