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07-04-2017 | Metformin | News

Mixed results from randomised trial of metformin in obese children

A randomized controlled trial shows some benefit of metformin treatment in prepubertal children with obesity, but not in pubertal participants.

06-20-2017 | Hyperglycemia | News

Gene analysis identifies potential metformin alternative

Analysis of gene expression changes underlying excess glucose production in the liver has identified a drug – derived from broccoli – with a mechanism of action complementary to that of metformin.

06-12-2017 | Metformin | ADA 2017 | News

REMOVAL: Mixed results for metformin in type 1 diabetes

The REMOVAL findings show an uncertain effect of metformin on atherosclerosis in overweight patients with type 1 diabetes, and only a transient effect on glycemic outcomes.

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05-08-2017 | Metformin | Editorial | Article

Metformin: What is new with this old medication?

With the arrival of slow-release formulations of metformin and the relaxation of guidelines concerning its use in patients with kidney disease, Carol Wysham explains how the population of patients who might benefit from this medication has expanded.

Journal articles and book chapters

02-02-2017 | Cardiovascular outcomes | Review | Article

Cardiovascular safety of non-insulin pharmacotherapy for type 2 diabetes

Many of the currently available oral anti-diabetic agents have clinically relevant cardiovascular effects. This expert review concludes that optimal approach to the reduction of cardiovascular risk in diabetic patients should focus on aggressive management of the standard cardiovascular risk factors rather than purely on intensive glycemic control.

Xu J & Rajaratnam R. Cardiovasc Diabetol 2017;16:18. doi:10.1186/s12933-017-0499-5

11-10-2016 | Type 2 diabetes | Review | Article

Clinical Pharmacokinetics and Pharmacodynamics of Antihyperglycemic Medications in Children and Adolescents with Type 2 Diabetes Mellitus

The authors discuss the prevalence of obesity and type 2 diabetes in children and adolescents and summarize published studies on the safety and effectiveness of antihyperglycemic medications in this population.

Akhlaghi F et al. Clin Pharmacokinet 2017; 56: 561–571. doi:10.1007/s40262-016-0472-6

10-17-2016 | Gestational diabetes | Review | Article

Pharmacological management of gestational diabetes mellitus

The review discusses pharmacological therapy for gestational diabetes, dealing with safety and efficacy, for both fetal and maternal morbidity consequences; as well as failure and success in establishing appropriate metabolic and glucose control.

Bergel R et al. Curr Diab Rep 2016; 16: 118. doi:10.1007/s11892-016-0802-y

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