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11-21-2017 | Diabetes prevention | Book chapter | Article

Pediatric Type 2 Diabetes: Prevention and Treatment Through a Life Course Health Development Framework

Authors: PhD, RN, FAAN Pamela Salsberry, PhD, RN Rika Tanda, PhD Sarah E. Anderson, MD Manmohan K. Kamboj

Publisher: Springer International Publishing



Estimates project that one in three US adults may have diabetes in 2050. Until very recently, type 2 diabetes mellitus (T2DM) was a disease diagnosed in adults, but as the childhood obesity epidemic has spread, the diagnosis of T2DM in adolescents has become more common. Early indicators suggest that the disease may be more severe and more difficult to manage when diagnosed in adolescents. It is projected that adolescents with T2DM will lose approximately 15 years of life. The economic burden of T2DM rises significantly as the years with disease increase. This grim forecast highlights that not only will the disease burden be significant but the economic burden will be high. The risk for developing T2DM begins in utero. Individual health development trajectories build from this starting point, the result of multiple factors that accumulate across time and are the result of biological conditioning during sensitive developmental periods. A major aim of this chapter is to demonstrate that a life course health development approach to pediatric T2DM is critical to a sound national strategy to prevent and treat pediatric T2DM. We review major factors known to influence the development of pediatric T2DM and track these across childhood. While these factors will likely change over the next decade, what will not change is the importance of placing these factors into context and recognizing that T2DM development is highly sensitive to the timing and social structures of multiple environmental exposures. Research recommendations are discussed through a life course lens.
Aaltonen, J., Ojala, T., Laitinen, K., Poussa, T., Ozanne, S., & Isolauri, E. (2011). Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: A prospective randomized controlled study. European Journal of Clinical Nutrition, 65(1), 10–19.
Agardh, E., Allebeck, P., Hallqvist, J., Moradi, T., & Sidorchuk, A. (2011). Type 2 diabetes incidence and socio-economic position: A systematic review and meta-analysis. International Journal of Epidemiology, 40(3), 804–818. PubMedCrossRef
Amed, S., Daneman, D., Mahmud, F. H., & Hamilton, J. (2010a). Type 2 diabetes in children and adolescents. Expert Review of Cardiovascular Therapy, 8(3), 393–406. PubMedCrossRef
Amed, S., Dean, H. J., Panagiotopoulos, C., Sellers, E. A., Hadjiyannakis, S., Laubscher, T. A., et al. (2010b). Type 2 diabetes, medication-induced diabetes, and monogenic diabetes in Canadian children: A prospective national surveillance study. Diabetes Care, 33(4), 786–791. PubMedPubMedCentralCrossRef
Amercian Diabetes Association. (2000). Type 2 diabetes in children and adolescents. Pediatrics, 105(3 Pt 1), 671–680. CrossRef
American Academy of Pedicatrics. (2012). Breastfeeding and the use of human milk. Pediatrics, 129(3), e827–e841. CrossRef
American Diabetes Association. (2010). Diagnosis and classification of diabetes mellitus. Diabetes Care, 33(Suppl 1), S62–S69. PubMedCentralCrossRef
Anderson, S. E., & Whitaker, R. C. (2010). Household routines and obesity in US preschool-aged children. Pediatrics, 125(1), 420–428. PubMedCrossRef
Anderson, S. E., Gooze, R. A., Lemeshow, S., & Whitaker, R. C. (2012). Quality of early maternal-child relationship and risk of adolescent obesity. Pediatrics, 129(1), 132–140. PubMedPubMedCentralCrossRef
Anderson, S. E., Lemeshow, S., & Whitaker, R. C. (2014). Maternal-infant relationship quality and risk of obesity at age 5.5 years in a national US cohort. BMC Pediatrics, 14(1), 54. PubMedPubMedCentralCrossRef
Armitage, J. A., Khan, I. Y., Taylor, P. D., Nathanielsz, P. W., & Poston, L. (2004). Developmental programming of the metabolic syndrome by maternal nutritional imbalance: How strong is the evidence from experimental models in mammals? The Journal of Physiology, 561(Pt 2), 355–377. PubMedPubMedCentralCrossRef
Armitage, J. A., Poston, L., Taylor, P., & D. (2008). Developmental origins of obesity and the metabolic syndrome: The role of maternal obesity. Frontiers of Hormone Research, 36, 73–84. PubMed
Arslanian, S. A., Bacha, F., Saad, R., & Gungor, N. (2005). Family history of type 2 diabetes is associated with decreased insulin sensitivity and an impaired balance between insulin sensitivity and insulin secretion in white youth. Diabetes Care, 28910, 115–119. CrossRef
Barker, D. J., Hales, C. N., Fall, C. H., Osmond, C., Phipps, K., & Clark, P. M. (1993). Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): Relation to reduced fetal growth. Diabetologia, 36(1), 62–67. PubMedCrossRef
Barker, A., Sharp, S. J., Timpson, N. J., Bouatia-Naji, N., Warrington, N. M., Kanoni, S., et al. (2011). Association of genetic loci with glucose levels in childhood and adolescence: A meta-analysis of over 6,000 children. Diabetes, 60(6), 1805–1812. PubMedPubMedCentralCrossRef
Barlow, S. E. (2007). Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: Summary report. Pediatrics, 120(Suppl 4), S164–S192. PubMedCrossRef
Barouki, R., Gluckman, P. D., Grandjean, P., Hanson, M., & Heindel, J. J. (2012). Developmental origins of non-communicable disease: Implications for research and public health. Environmental Health : A Global Access Science Source, 11, 42. CrossRef
Barton, M. (2010). Screening for obesity in children and adolescents: US preventive services task Force recommendation statement. Pediatrics, 125(2), 361–367. PubMedCrossRef
Battista, M. C., Hivert, M. F., Duval, K., & Baillargeon, J. P. (2011). Intergenerational cycle of obesity and diabetes: How can we reduce the burdens of these conditions on the health of future generations? Experimental Diabetes Research, 2011, 596060. doi: 10.​1155/​2011/​596060. PubMedPubMedCentralCrossRef
Bell, J. F., & Zimmerman, F. J. (2010). Shortened nighttime sleep duration in early life and subsequent childhood obesity. Archives of Pediatrics & Adolescent Medicine, 164(9), 840–845. CrossRef
Bell, R. A., Mayer-Davis, E. J., Beyer, J. W., D’Agostino, R. B., Jr., Lawrence, J. M., Linder, B., et al. (2009). Diabetes in non-Hispanic white youth: Prevalence, incidence, and clinical characteristics: The SEARCH for diabetes in youth study. Diabetes Care, 32(Suppl 2), S102–S111. PubMedPubMedCentralCrossRef
Berends, L. M., & Ozanne, S. E. (2012). Early determinants of type-2 diabetes. Best Practice & Research. Clinical Endocrinology & Metabolism, 26(5), 569–580. CrossRef
Bertin, E., Gangnerau, M. N., Bellon, G., Bailbe, D., Arbelot De Vacqueur, A., & Portha, B. (2002). Development of beta-cell mass in fetuses of rats deprived of protein and/or energy in last trimester of pregnancy. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 283(3), R623–R630. PubMedCrossRef
Bocca, G., Corpeleijn, E., Stolk, R. P., & Sauer, P. J. J. (2012a). Results of a multidisciplinary treatment program in 3-year-old to 5-year-old overweight or obese children: A randomized controlled clinical trial. Archives of Pediatrics & Adolescent Medicine, 166(12), 1109–1115. CrossRef
Bocca, G., Corpeleijn, E., Stolk, R. P., & Sauer, P. J. (2012b). Results of a multidisciplinary treatment program in 3-year-old to 5-year-old overweight or obese children: A randomized controlled clinical trial. Archives of Pediatrics & Adolescent Medicine, 166(12), 1109–1115. CrossRef
Boekelheide, K., Blumberg, B., Chapin, R. E., Cote, I., Graziano, J. H., Janesick, A., et al. (2012). Predicting later-life outcomes of early-life exposures. Environmental Health Perspectives, 120(10), 1353–1361. PubMedPubMedCentralCrossRef
Boyle, J. P., Thompson, T. J., Gregg, E. W., Barker, L. E., & Williamson, D. F. (2010). Projection of the year 2050 burden of diabetes in the US adult population: Dynamic modeling of incidence, mortality, and prediabetes prevalence. Population Health Metrics, 8, 29. doi: 10.​1186/​1478-7954-8-29. CrossRefPubMedPubMedCentral
Brandt, M. L., Harmon, C. M., Helmrath, M. A., Inge, T. H., McKay, S. V., & Michalsky, M. P. (2010). Morbid obesity in pediatric diabetes mellitus: Surgical options and outcomes. Nature reviews. Endocrinology, 6(11), 637–645. PubMed
Brotman, L. M., Dawson-McClure, S., Huang, K. Y., Theise, R., Kamboukos, D., Wang, J., et al. (2012). Early childhood family intervention and long-term obesity prevention among high-risk minority youth. Pediatrics, 129(3), e621–e628. PubMedPubMedCentralCrossRef
Brown, T., & Summerbell, C. (2009). Systematic review of school-based interventions that focus on changing dietary intake and physical activity levels to prevent childhood obesity: An update to the obesity guidance produced by the National Institute for health and clinical excellence. Obesity Reviews, 10(1), 110–141. PubMedCrossRef
Brunton, P. J. (2010). Resetting the dynamic range of hypothalamic-pituitary-adrenal axis stress responses through pregnancy. Journal of Neuroendocrinology, 22(11), 1198–1213. PubMedCrossRef
Burns, S. F., Lee, S., Bacha, F., Tfayli, H., Hannon, T. S., & Arslanian, S. A. (2014). Pre-diabetes in overweight youth and early atherogenic risk. Metabolism, 63(12), 1528–1235. PubMedPubMedCentralCrossRef
Burt Solorzano, C. M., & McCartney, C. R. (2010). Obesity and the pubertal transition in girls and boys. Reproduction, 140(3), 399–410. PubMedPubMedCentralCrossRef
Caballero, B., Clay, T., Davis, S. M., Ethelbah, B., Rock, B. H., Lohman, T., et al. (2003). Pathways: A school-based, randomized controlled trial for the prevention of obesity in American Indian schoolchildren. American Journal of Clinical Nutrition, 78(5), 1030–1038. CrossRef
Campbell, K. J., Lioret, S., McNaughton, S. A., Crawford, D. A., Salmon, J., Ball, K., et al. (2013). A parent-focused intervention to reduce infant obesity risk behaviors: A randomized trial. Pediatrics, 131(4), 652–660. doi: 10.​1542/​peds.​2012-2576. PubMedCrossRef
Cenit, M. C., Matzaraki, V., Tigchelaar, E. F., & Zhernakova, A. (2014). Rapidly expanding knowledge on the role of the gut microbiome in health and disease. Biochimica et Biophysica Acta, 1842(10), 1981–1992. PubMedCrossRef
Christian, L. M. (2012). Physiological reactivity to psychological stress in human pregnancy: Current knowledge and future directions. Progress in Neurobiology, 99(2), 106–116. doi: 10.​1016/​j.​pneurobio.​2012.​07.​003. PubMedPubMedCentralCrossRef
Copeland, K. C., Zeitler, P., Geffner, M., Guandalini, C., Higgins, J., Hirst, K., et al. (2011). Characteristics of adolescents and youth with recent-onset type 2 diabetes: The TODAY cohort at baseline. Journal of Clinical Endocrinology and Metabolism, 96(1), 159–167. PubMedCrossRef
Courcoulas, A., Goodpaster, B., Eagleton, J., Belle, S., Kalarchian, M., Lang, W., et al. (2014). Surgical vs medical treatments for type 2 diabetes mellitus: A randomized clinical trial. JAMA Surgery, 7(149), 707–715. CrossRef
Crume, T. L., Ogden, L. G., Mayer-Davis, E. J., Hamman, R. F., Norris, J. M., Bischoff, K. J., et al. (2012). The impact of neonatal breast-feeding on growth trajectories of youth exposed and unexposed to diabetes in utero: The EPOCH study. International Journal of Obesity, 36(4), 529–534. PubMedCrossRef
Dabelea, D., Bell, R. A., D’Agostino, R. B., Jr., Imperatore, G., Johansen, J. M., Linder, B., et al. (2007). Incidence of diabetes in youth in the United States. JAMA, 297(24), 2716–2724. PubMedCrossRef
Dabelea, D., Dolan, L. M., D’Agostino, R., Jr., Hernandez, A. M., McAteer, J. B., Hammon, R. F., et al. (2011). Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth. Diabetologia, 54(3), 535–539. PubMedCrossRef
Dabelea, D., Mayer-Davis, E. J., Saydah, S., Imperatore, G., Linder, B., et al. (2014). Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA, 311(17), 1778–1786. PubMedPubMedCentralCrossRef
Danielsson, P., Kowalski, J., Ekblom, O., & Marcus, C. (2012a). Response of severely obese children and adolescents to behavioral treatment. Archives of Pediatrics & Adolescent Medicine, 166(12), 1103–1108. CrossRef
Danielsson, P., Kowalski, J., Ekblom, O., & Marcus, C. (2012b). Response of severely obese children and adolescents to behavioral treatment. Archives of Pediatrics & Adolescent Medicine, 166(12), 1103–1108. CrossRef
Davis, C. L., Pollock, N. K., Waller, J. L., Allison, J. D., Dennis, B. A., Bassali, R., et al. (2012). Exercise dose and diabetes risk in overweight and obese children: A randomized controlled trial. JAMA, 308(11), 1103–1112. PubMedPubMedCentralCrossRef
Demmer, R. T., Zuk, A. M., Rosenbaum, M., & Desvarieux, M. (2013). Prevalence of diagnosed and undiagnosed type 2 diabetes mellitus among US adolescents: Results from the continuous NHANES, 1999-2010. American Journal of Epidemiology, 178(7), 1106–1113. PubMedPubMedCentralCrossRef
Devaraj, S., Hemarajata, P., & Versalovic, J. (2013). The human gut microbiome and body metabolism: Implications for obesity and diabetes. Clinical Chemistry, 59(4), 617–628. PubMedPubMedCentralCrossRef
Dyer, J. S., & Rosenfeld, C. R. (2011). Metabolic imprinting by prenatal, perinatal, and postnatal overnutrition: A review. Seminars in Reproductive Medicine, 29(3), 266–276. PubMedCrossRef
van Eijsden, M., Vrijkotte, T. G., Gemke, R. J., & van der Wal, M. F. (2011). Cohort profile: The Amsterdam born children and their development (ABCD) study. International Journal of Epidemiology, 40(5), 1176–1186. PubMedCrossRef
Ekelund, U., Ong, K. K., Linne, Y., Neovius, M., Brage, S., Dunger, D. B., et al. (2007). Association of weight gain in infancy and early childhood with metabolic risk in young adults. The Journal of Clinical Endocrinology and Metabolism, 92(1), 98–103. PubMedCrossRef
Elder, D. A., Herbers, P. M., Weis, T., Standiford, D., Woo, J. G., & D’Alessio, D. A. (2012). Beta-cell dysfunction in adolescents and adults with newly diagnosed type 2 diabetes mellitus. Journal of Pediatrics, 160(6), 904–910. CrossRef
Eriksson, J. G. (2006). Early growth, and coronary heart disease and type 2 diabetes: Experiences from the Helsinki birth cohort studies. International Journal of Obesity, 30(Suppl 4), S18–S22. PubMedCrossRef
Eriksson, J. G. (2011). Early growth and coronary heart disease and type 2 diabetes: Findings from the Helsinki birth cohort study (HBCS). The American Journal of Clinical Nutrition, 94(6 Supplement), 1799S–1802S. PubMedCrossRef
Eriksson, J. G., Osmond, C., Kajantie, E., Forsen, T. J., & Barker, D. J. (2006). Patterns of growth among children who later develop type 2 diabetes or its risk factors. Diabetologia, 49(12), 2853–2858. PubMedCrossRef
Fabricius-Bjerre, S., Jensen, R. B., Faerch, K., Larsen, T., Molgaard, C., Michaelsen, K. F., et al. (2011). Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence. PloS One, 6(6), e20595. doi: 10.​1371/​journal.​pone.​0020595. PubMedPubMedCentralCrossRef
Ferguson, M. A., Gutin, B., Le, N. A., Karp, W., Litaker, M., Humphries, M., et al. (1999). Effects of exercise training and its cessation on components of the insulin resistance syndrome in obese children. International Journal of Obesity and Related Metabolic Disorders, 23(8), 889–895. PubMedCrossRef
Fernandez-Twinn, D. S., Wayman, A., Ekizoglou, S., Martin, M. S., Hales, C. N., & Ozanne, S. E. (2005). Maternal protein restriction leads to hyperinsulinemia and reduced insulin-signaling protein expression in 21-mo-old female rat offspring. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 288(2), R368–R373. PubMedCrossRef
Foster, G. D., Linder, B., Baranowski, T., Cooper, D. M., Goldberg, L., Harrell, J. S., et al. (2010). A school-based intervention for diabetes risk reduction. New England Journal of Medicine, 363(5), 443–453. CrossRef
Gabbe, S. G., Landon, M. B., Warren-Boulton, E., & Fradkin, J. (2012). Promoting health after gestational diabetes: A National Diabetes Education Program call to action. Obstetrics and Gynecology, 119(1), 171–176. PubMedCrossRef
Gaffney, K. F., Kitsantas, P., & Cheema, J. (2012). Clinical practice guidelines for feeding behaviors and weight-for-age at 12 months: A secondary analysis of the infant feeding practices study II. Worldviews on Evidence- Based Nursing, 9(4), 234–242. PubMedCrossRef
Gaffney, K. F., Kitsantas, P., Brito, A., & Swamidoss, C. S. (2014). Postpartum depression, infant feeding practices, and infant weight gain at six months of age. Journal of Pediatric Health Care, 28(1), 43–50. PubMedCrossRef
Garofano, A., Czernichow, P., & Breant, B. (1998). Beta-cell mass and proliferation following late fetal and early postnatal malnutrition in the rat. Diabetologia, 41(9), 1114–1120. PubMedCrossRef
Gillis, B., Mobley, C., Stadler, D. D., Hartstein, J., Virus, A., Volpe, S. L., et al. (2009). Rationale, design and methods of the HEALTHY study nutrition intervention component. International Journal of Obesity, 33(Suppl 4), S29–S36. PubMedCrossRef
Gillman, M. W., Oakey, H., Baghurst, P. A., Volkmer, R. E., Robinson, J. S., & Crowther, C. A. (2010). Effect of treatment of gestational diabetes mellitus on obesity in the next generation. Diabetes Care, 33(5), 964–968. PubMedPubMedCentralCrossRef
Gluckman, P. D., Hanson, M. A., Cooper, C., & Thornburg, K. L. (2008). Effect of in utero and early-life conditions on adult health and disease. New England Journal of Medicine, 359(1), 61–73. CrossRef
Groop, L. C., & Tuomi, T. (1997). Non-insulin-dependent diabetes mellitus–a collision between thrifty genes and an affluent society. Annals of Medicine, 29, 37–53. PubMedCrossRef
Grote, V., Vik, T., von Kries, R., Luque, V., Socha, J., Verducci, E., et al. (2010). Maternal postnatal depression and child growth: A European cohort study. BMC Pediatrics, 10, 14. doi: 10.​1186/​1471-2431-10-14. PubMedPubMedCentralCrossRef
Hadar, E., & Hod, M. (2010). Establishing consensus criteria for the diagnosis of diabetes in pregnancy following the HAPO study. Annals of the New York Academy of Sciences, 1205, 88–93. PubMedCrossRef
Haines, L., Wan, K. C., Lynn, R., Barrett, T. G., & Shield, J. P. (2007). Rising incidence of type 2 diabetes in children in the U.K. Diabetes Care, 30(5), 1097–1101. PubMedCrossRef
Haines, J., McDonald, J., O’Brien, A., Sherry, B., Bottino, C. J., Schmidt, M. E., et al. (2013). Healthy habits, happy homes: Randomized trial to improve household routines for obesity prevention among preschool aged children. JAMA Pediatrics, 167(11), 1072–1079. PubMedCrossRef
Hales, C. N., & Barker, D. J. (2001). The thrifty phenotype hypothesis. British Medical Bulletin, 60, 5–20. PubMedCrossRef
Halfon, N., & Forrest, C. B. (2017). The emerging theoretical framework of life course health development. In N. Halfon, C. B. Forrest, R. M. Lerner, & E. Faustman (Eds.), Handbook of life course health-development science. Cham: Springer.
Harvey-Berino, J., & Rourke, J. (2003). Obesity prevention in preschool native-American children: A pilot study using home visiting. Obesity Research, 11(5), 606–611. PubMedCrossRef
Herbst, A., Kapellen, T., Schober, E., Graf, C., Meissner, T., & Holl, R. (2014). Impact of regular physical activity on blood glucose control and cardiovascular risk factors in adolescents with type 2 diabetes mellitus – a multicenter study of 578 patients from 225 centres. Pediatric Diabetes, 16(3), 204–210. PubMedCrossRef
Hesketh, K. D., & Campbell, K. J. (2010). Interventions to prevent obesity in 0-5 year olds: An updated systematic review of the literature. Obesity, 18(Supple 1), S27–S35. PubMedCrossRef
Hirst, K., Baranowski, T., DeBar, L., Foster, G. D., Kaufman, F., Kennel, P., et al. (2009). HEALTHY study rationale, design and methods: Moderating risk of type 2 diabetes in multi-ethnic middle school students. International Journal of Obesity, 33(Suppl 4), S4–20. PubMed
Hiscock, H., Scalzo, K., Canterford, L., & Wake, M. (2011). Sleep duration and body mass index in 0-7-year olds. Archives of Disease in Childhood, 96(8), 735–739. PubMedCrossRef
Hoet, J. J., Dahri, S., Snoeck, A., Reusens-Billen, B., & Remacle, C. (1992). Importance of diets and their effect on fetal development: Function and structure of the endocrine pancreas following protein deficiency during intrauterine life. Bulletin et Mémoires de l’Académie Royale de Médecine de Belgique, 147(3–5), 174–181. discussion 81–83. PubMed
Imperatore, G., Boyle, J. P., Thompson, T. J., Case, D., Dabelea, D., Hamman, R. F., et al. (2012). Projections of type 1 and type 2 diabetes burden in the U.S. population aged <20 years through 2050: Dynamic modeling of incidence, mortality, and population growth. Diabetes Care, 35(12), 2515–2520. PubMedPubMedCentralCrossRef
ISPAD. (2011). Global IDF/ISPAD guideline for childhood and Pediatric diabetes. Brussels, Belgium: International Diabetes Foundation.
James, D. C., & Lessen, R. (2009). Position of the American dietetic association: Promoting and supporting breastfeeding. Journal of the American Dietetic Association, 109(11), 1926–1942.
Jeffery, A. N., Metcalf, B. S., Hosking, J., Streeter, A. J., Voss, L. D., & Wilkin, T. J. (2012). Age before stage: Insulin resistance rises before the onset of puberty: A 9-year longitudinal study (EarlyBird 26). Diabetes Care, 35(3), 536–541. PubMedPubMedCentralCrossRef
Johnson, C. L., & Versalovic, J. (2012). The human microbiome and its potential importance to pediatrics. Pediatrics, 129(5), 950–960. PubMedPubMedCentralCrossRef
Kanaka-Gantenbein, C. (2010). Fetal origins of adult diabetes. Annals of the New York Academy of Sciences, 1205, 99–105. PubMedCrossRef
Kapoor, A., Dunn, E., Kostaki, A., Andrews, M. H., & Matthews, S. G. (2006). Fetal programming of hypothalamo-pituitary-adrenal function: Prenatal stress and glucocorticoids. The Journal of Physiology, 572(Pt 2), 31–44. PubMedPubMedCentralCrossRef
Katoh, S., Lehtovirta, M., Kaprio, J., Harjutsalo, V., Koskenvuo, M., Eriksson, J., et al. (2005). Genetic and environmental effects on fasting and postchallenge plasma glucose and serum insulin values in Finnish twins. Journal of Clinical Endocrinology and Metabolism, 90(5), 2642–2647. PubMedCrossRef
Kaufman, F. R., Hirst, K., Linder, B., Baranowski, T., Cooper, D. M., Foster, G. D., et al. (2009). Risk factors for type 2 diabetes in a sixth-grade multiracial cohort: The HEALTHY study. Diabetes Care, 32(5), 953–955. PubMedCrossRef
Kempf, K., Rathmann, W., & Herder, C. (2008). Impaired glucose regulation and type 2 diabetes in children and adolescents. Diabetes/Metabolism Research and Reviews, 24, 427–437. PubMedCrossRef
Kim, S. Y., England, J. L., Sharma, J. A., & Njoroge, T. (2011). Gestational diabetes mellitus and risk of childhood overweight and obesity in offspring: A systematic review. Experimental Diabetes Research, 2011, 541308. PubMedPubMedCentralCrossRef
Kitzmann, K. M., Dalton, W. T., 3rd, Stanley, C. M., Beech, B. M., Reeves, T. P., et al. (2010). Lifestyle interventions for youth who are overweight: A meta-analytic review. Health Psychology, 29(1), 91–101. PubMedCrossRef
Klingenberg, L., Christensen, L. B., Hjorth, M. F., Zangenberg, S., Chaput, J. P., Sjodin, A., et al. (2013). No relation between sleep duration and adiposity indicators in 9-36 months old children: The SKOT cohort. Pediatric Obesity, 8(1), e14–e18. PubMedCrossRef
Knowlden, A. P., & Sharma, M. (2012). Systematic review of family and home-based interventions targeting paediatric overweight and obesity. Obesity Reviews, 13(6), 499–508. PubMedCrossRef
Koren, O., Goodrich, J. K., Cullender, T. C., Spor, A., Laitinen, K., Backhed, H. K., et al. (2012). Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell, 150(3), 470–480. PubMedPubMedCentralCrossRef
Kramer, M. S., Matush, L., Vanilovich, I., Platt, R. W., Bogdanovich, N., Sevkovskaya, Z., et al. (2009). A randomized breast-feeding promotion intervention did not reduce child obesity in Belarus. The Journal of Nutrition, 139(2), 417S–421S. PubMedCrossRef
Lawrence, J., Mayer-Davis, E., Ryeynolds, K., Beyer, J., Pettitt, D., D’Agostino, R. B., et al. (2009a). Diabetes in Hispanic American youths. Diabetes Care, 32(Supplement 2), S123–S132. PubMedPubMedCentralCrossRef
Lawrence, J. M., Mayer-Davis, E. J., Reynolds, K., Beyer, J., Pettitt, D. J., D’Agostino, R. B., et al. (2009b). Diabetes in Hispanic American youth: Prevalence, incidence, demographics, and clinical characteristics: The SEARCH for diabetes in youth study. Diabetes Care, 32(Suppl 2), S123–S132. PubMedPubMedCentralCrossRef
Lee, Y. (2013). Diabetes care for emerging adults: Transition from pediatric to adult diabetes care systems. Annals of Pediatric Endocrinology & Metabolism, 18, 106–110. CrossRef
Ley, S. H., Hanley, A. J., Sermer, M., Zinman, B., & O’Connor, D. L. (2012). Associations of prenatal metabolic abnormalities with insulin and adiponectin concentrations in human milk. The American Journal of Clinical Nutrition, 95(4), 867–874. PubMedCrossRef
Li, R., Bilik, D., Brown, M. B., Zhang, P., Ettner, S. L., Ackerman, R. T., et al. (2013). Medical costs associated with type 2 diabetes complications and comorbidities. The American Journal of Managed Care, 19(5), 421–430. PubMedPubMedCentral
Liu, L. L., Yi, J. P., Beyer, J., Mayer-Davis, E. J., Dolan, L. M., Dabelea, D. M., et al. (2009). Type 1 and type 2 diabetes in Asian and Pacific Islander U.S. youth: The SEARCH for diabetes in youth study. Diabetes Care, 32(Suppl 2), S133–S140. PubMedPubMedCentralCrossRef
Liu, J., Yu, P., Qian, W., Li, Y., Zhao, J., Huan, F., et al. (2013). Perinatal bisphenol a exposure and adult glucose homeostasis: Identifying critical windows of exposure. PloS One, 8(5), e64143. PubMedPubMedCentralCrossRef
Luepker, R. V., Perry, C. L., McKinlay, S. M., Nader, P. R., Parcel, G. S., Stone, E. J., et al. (1996). Outcomes of a field trial to improve children’s dietary patterns and physical activity. The child and adolescent trial for cardiovascular health. CATCH collaborative group. The Journal of the American Medical Association, 275(10), 768–776. PubMedCrossRef
Martin, R. M., Patel, R., Kramer, M. S., Vilchuck, K., Bogdanovich, N., Sergeichick, N., et al. (2014). Effects of promoting longer-term and exclusive breastfeeding on cardiometabolic risk factors at age 11.5 years: A cluster-randomized, controlled trial. Circulation, 129(3), 321–329.
Martin-Gronert, M. S., & Ozanne, S. E. (2012). Mechanisms underlying the developmental origins of disease. Reviews in Endocrine & Metabolic Disorders, 13(2), 85–92. CrossRef
Maull, E. A., Ahsan, H., Edwards, J., Longnecker, M. P., Navas-Acien, A., Pi, J., et al. (2012). Evaluation of the association between arsenic and diabetes: A National Toxicology Program workshop review. Environmental Health Perspectives, 120(12), 1658–1670. PubMedPubMedCentralCrossRef
May, A. L., Kuklina, E. V., & Yoon, P. W. (2012). Prevalence of cardiovascular disease risk factors among US adolescents, 1999–2008. Pediatrics, 129(6), 1035–1041. PubMedCrossRef
Mayer-Davis, E. J., Rifas-Shiman, S. L., Zhou, L., Hu, F. B., Colditz, G. A., & Gillman, M. W. (2006). Breast-feeding and risk for childhood obesity: Does maternal diabetes or obesity status matter? Diabetes Care, 29(10), 2231–2237. PubMedCrossRef
Mayer-Davis, E. J., Dabelea, D., Lamichhane, A. P., D’Agostino, R. B., Jr., Liese, A. D., et al. (2008). Breast-feeding and type 2 diabetes in the youth of three ethnic groups: The SEARCh for diabetes in youth case-control study. Diabetes Care, 31(3), 470–475. PubMedCrossRef
Mayer-Davis, E. J., Beyer, J., Bell, R. A., Dabelea, D., D’Agostino, R., Jr., Imperatorek, G., et al. (2009). Diabetes in African American youth: Prevalence, incidence, and clinical characteristics: The SEARCH for diabetes in youth study. Diabetes Care, 32(Supplement 2), S112–S122. PubMedPubMedCentralCrossRef
McEwen, B. S. (2008). Understanding the potency of stressful early life experiences on brain and body function. Metabolism Clinical and Experimental, 57(Suppl 2), S11–S15. PubMedPubMedCentralCrossRef
McLearn, K. T., Minkovitz, C. S., Strobino, D. M., Marks, E., & Hou, W. (2006). Maternal depressive symptoms at 2 to 4 months post partum and early parenting practices. Archives of Pediatrics & Adolescent Medicine, 160(3), 279–284. CrossRef
McMillen, I. C., & Robinson, J. S. (2005). Developmental origins of the metabolic syndrome: Prediction, plasticity, and programming. Physiological Reviews, 85(2), 571–633. PubMedCrossRef
McMurray, R. G., Bassin, S., Jago, R., Bruecker, S., Moe, E. L., Murray, T., et al. (2009). Rationale, design and methods of the HEALTHY study physical education intervention component. International Journal of Obesity, 33(Suppl 4), S37–S43. PubMedCrossRef
Meaney, M. J., Szyf, M., & Seckl, J. R. (2007). Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends in Molecular Medicine, 13(7), 269–277. PubMedCrossRef
Metzger, B. E., Lowe, L. P., Dyer, A. R., Trimble, E. R., Chaovarindr, U., Coustan, D. R., et al. (2008). Hyperglycemia and adverse pregnancy outcomes. The New England Journal of Medicine, 358(19), 1991–2002. PubMedCrossRef
Metzger, B. E., Gabbe, S. G., Persson, B., Buchanan, T. A., Catalano, P. A., Damm, P., et al. (2010). International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care, 33(3), 676–682. PubMedCrossRef
Morandi, A., Maschio, M., Marigliano, M., Miraglia Del Giudice, E., Moro, B., Peverelli, P., et al. (2014). Screening for impaired glucose tolerance in obese children and adolescents: A validation and implementation study. Pediatric Obesity, 9(1), 17–25. PubMedCrossRef
Morgan, A. R. (2012). Determining genetic risk factors for pediatric type 2 diabetes. Current Diabetes Reports, 12(1), 88–92. PubMedCrossRef
Morris, D. H., Khunti, K., Achana, F., Srinivasan, B., Gray, L. J., Davies, M. J., et al. (2013). Progression rates from HbA(1c) 6.0-6.4% and other prediabetes definitions to type 2 diabetes: A meta-analysis. Diabetologia, 56(7), 1489–1493. PubMedCrossRef
Morrison, K. M., Xu, L., Tarnopolsky, M., Yusuf, Z., Atkinson, S. A., & Yusuf, S. (2012). Screening for dysglycemia in overweight youth presenting for weight management. Diabetes Care, 35(4), 711–716. PubMedPubMedCentralCrossRef
Moses, R. G. (2010). New consensus criteria for GDM: Problem solved or a pandora’s box? Diabetes Care, 33(3), 690–691. PubMedPubMedCentralCrossRef
Navas-Acien, A., Silbergeld, E. K., Pastor-Barriuso, R., & Guallar, E. (2008). Arsenic exposure and prevalence of type 2 diabetes in US adults. JAMA, 300(7), 814–822. PubMedCrossRef
Neville, M. C., Anderson, S. M., McManaman, J. L., Badger, T. M., Bunik, M., Contractor, N., et al. (2012). Lactation and neonatal nutrition: Defining and refining the critical questions. Journal of Mammary Gland Biology and Neoplasia, 17(2), 167–188. doi: 10.​1007/​s10911-012-9261-5. PubMedPubMedCentralCrossRef
Ong, K. K. (2010). Early determinants of obesity. Endocrine Development, 19, 53–61. PubMedCrossRef
Pervanidou, P., & Chrousos, G. P. (2011). Stress and obesity/metabolic syndrome in childhood and adolescence. International Journal of Pediatric Obesity, 6(Supplement 1), 21–28. PubMedCrossRef
Pervanidou, P., & Chrousos, G. P. (2012). Metabolic consequences of stress during childhood and adolescence. Metabolism, 61(5), 611–619. PubMedCrossRef
Peters, A., & Laffel, L. (2011). Diabetes care for emerging adults: Recommendations for transition from pediatric to adult diabetes care systems: A position statement of the American Diabetes Association. Diabetes Care, 34(11), 2477–2485. PubMedPubMedCentralCrossRef
Plagemann, A., Harder, T., Franke, K., & Kohlhoff, R. (2002). Long-term impact of neonatal breast-feeding on body weight and glucose tolerance in children of diabetic mothers. Diabetes Care, 25(1), 16–22. PubMedCrossRef
Prince, A. L., Antony, K. M., Ma, J., & Aagaard, K. M. (2014). The microbiome and development: A mother’s perspective. Seminars in Reproductive Medicine, 32(1), 14–22. PubMedCrossRef
Raman, A., Ritchie, L. D., Lustig, R. H., Fitch, M. D., Hudes, M. L., & Fleming, S. E. (2010). Insulin resistance is improved in overweight African American boys but not in girls following a one-year multidisciplinary community intervention program. Journal of Pediatric Endocrinology & Metabolism, 23(1–2), 109–120.
Rhodes, E. T., Prosser, L. A., Hoerger, T. J., Lieu, T., Ludwig, D. S., & Laffel, L. M. (2012). Estimated morbidity and mortality in adolescents and young adults diagnosed with type 2 diabetes mellitus. Diabetic Medicine, 29(4), 453–463. PubMedCrossRef
Ritchie, L. D., Sharma, S., Ikeda, J. P., Mitchell, R. A., Raman, A., Green, B. S., et al. (2010). Taking action together: A YMCA-based protocol to prevent type-2 diabetes in high-BMI inner-city African American children. Trials, 11, 60. PubMedPubMedCentralCrossRef
Robinson, S., Ntani, G., Simmonds, S., Syddall, H., Dennison, E., Sayer, A. A., et al. (2013). Type of milk feeding in infancy and health behaviours in adult life: Findings from the Hertfordshire cohort study. The British Journal of Nutrition, 109(6), 1114–1122. PubMedCrossRef
Rolland-Cachera, M. F. (2011). Childhood obesity: Current definitions and recommendations for their use. International Journal of Pediatric Obesity, 6(5–6), 325–331. PubMedCrossRef
Rosenbaum, M., Nonas, C., Weil, R., Horlick, M., Fennoy, I., Vargas, I., et al. (2007). School-based intervention acutely improves insulin sensitivity and decreases inflammatory markers and body fatness in junior high school students. The Journal of Clinical Endocrinology and Metabolism, 92(2), 504–508. PubMedCrossRef
Rosenbloom, A. L., Joe, J. R., Young, R. S., & Winter, W. E. (1999). Emerging epidemic of type 2 diabetes in youth. Diabetes Care, 22(2), 345–354. PubMedCrossRef
Rosenbloom, A. L., Silverstein, J. H., Amemiya, S., Zeitler, P., & Klingensmith, G. J. (2008). ISPAD clinical practice consensus guidelines 2006-2007. Type 2 diabetes mellitus in the child and adolescent. Pediatric Diabetes, 9(5), 512–526. PubMedCrossRef
Saelens, B. E., Grow, H. M., Stark, L. J., Seeley, R. J., & Roehrig, H. (2011). Efficacy of increasing physical activity to reduce children’s visceral fat: A pilot randomized controlled trial. International Journal of Pediatric Obesity, 6(2), 102–112. PubMedCrossRef
Salsberry, P. J., & Reagan, P. B. (2005). Dynamics of early childhood overweight. Pediatrics, 116(6), 1329–1338. PubMedCrossRef
Samuelsson, A. M., Matthews, P. A., Argenton, M., Christie, M. R., McConnell, J. M., et al. (2008). Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: A novel murine model of developmental programming. Hypertension, 51(2), 383–392. PubMedCrossRef
Savoye, M., Shaw, M., Dziura, J., Tamborlane, W. V., Rose, P., Guandalini, C., et al. (2007). Effects of a weight management program on body composition and metabolic parameters in overweight children: A randomized controlled trial. JAMA, 297(24), 2697–2704. PubMedCrossRef
Savoye, M., Nowicka, P., Shaw, M., Yu, S., Dziura, J., Chavent, G., et al. (2011). Long-term results of an obesity program in an ethnically diverse pediatric population. Pediatrics, 127(3), 402–410. PubMedPubMedCentralCrossRef
Savoye, M., Caprio, S., Dziura, J., Camp, A., Germain, G., Summers, C., et al. (2014). Reversal of early abnormalities in glucose metabolism in obese youth: Results of an intensive lifestyle randomized controlled trial. Diabetes Care, 37(2), 317–324. PubMedPubMedCentralCrossRef
Schore, A. N. (2005). Back to basics: Attachment, affect regulation, and the developing right brain: Linking developmental neuroscience to pediatrics. Pediatrics in Review, 26(6), 204–217. PubMedCrossRef
Sebert, S., Sharkey, D., Budge, H., & Symonds, M. E. (2011). The early programming of metabolic health: Is epigenetic setting the missing link? The American Journal of Clinical Nutrition, 94(6 Supplement), 1953S–1958S. PubMedCrossRef
Seki, Y., Williams, L., Vuguin, P. M., & Charron, M. J. (2012). Minireview: Epigenetic programming of diabetes and obesity: Animal models. Endocrinology, 153(3), 1031–1038. PubMedPubMedCentralCrossRef
Shaw, J. E., Socree, R. A., & Zimmet, P. Z. (2010). Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice, 87, 4–14. PubMedCrossRef
Shonkoff, J. P., & Garner, A. S. (2012). The lifelong effects of early childhood adversity and toxic stress. Pediatrics, 129(1), e232–e246. CrossRefPubMed
Silverman, B. L., Rizzo, T. A., Cho, N. H., & Metzger, B. E. (1998). Long-term effects of the intrauterine environment. The Northwestern University diabetes in pregnancy Center. Diabetes Care, 21(Suppl 2), B142–B149. PubMed
Simeoni, U., & Barker, D. J. (2009). Offspring of diabetic pregnancy: Long-term outcomes. Seminars in Fetal & Neonatal Medicine, 14(2), 119–124. CrossRef
Sinclair, K. D., Lea, R. G., Rees, W. D., & Young, L. E. (2007). The developmental origins of health and disease: Current theories and epigenetic mechanisms. Society of Reproduction and Fertility Supplement, 64, 425–443. PubMed
Sinha, R., Fisch, G., Teague, B., Tamborlane, W. V., Banyas, B., Allen, K., et al. (2002). Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. The New England Journal of Medicine, 346(11), 802–810. PubMedCrossRef
Skouteris, H., McCabe, M., Swinburn, B., Newgreen, V., Sacher, P., & Chadwick, P. (2011). Parental influence and obesity prevention in pre-schoolers: A systematic review of interventions. Obesity Reviews, 12(5), 315–328. PubMedCrossRef
Skouteris, H., McCabe, M., Ricciardelli, L., Milgrom, J., Baur, L., Aksan, N., et al. (2012). Parent–child interactions and obesity prevention: A systematic review of the literature. Early Child Development and Care, 182(2), 153–174. CrossRef
Smith, B. T., Lynch, J. W., Fox, C. S., Harper, S., Abrahamowicz, M., Almeida, N. D., et al. (2011). Life-course socioeconomic position and type 2 diabetes mellitus: The Framingham offspring study. American Journal of Epidemiology, 173(4), 438–447. PubMedPubMedCentralCrossRef
Snieder, H., Boomsma, D. I., van Doornen, L. J., & Neale, M. C. (1999). Bivariate genetic analysis of fasting insulin and glucose levels. Genetic Epidemiology, 16(4), 426–446. PubMedCrossRef
Stark, L. J., Clifford, L. M., Towner, E. K., Filigno, S. S., Zion, C., Bolling, C., et al. (2014). A pilot randomized controlled trial of a behavioral family-based intervention with and without home visits to decrease obesity in preschoolers. Journal of Pediatric Psychology, 39(9), 1001–1012. doi: 10.​1093/​jpepsy/​jsu059. PubMedPubMedCentralCrossRef
Szajewska, H. (2013). Microbiota modulation: Can probiotics prevent/treat disease in pediatrics? Nestle Nutrition Institute Workshop Series, 77, 99–110. PubMedCrossRef
Tamayo, T., Christian, H., & Rathmann, W. (2010). Impact of early psychosocial factors (childhood socioeconomic factors and adversities) on future risk of type 2 diabetes, metabolic disturbances and obesity: A systematic review. BMC Public Health, 10, 525. doi: 10.​1186/​1471-2458-10-525. PubMedPubMedCentralCrossRef
Tamayo, T., Jacobs, D. R., Jr., Strassburger, K., Giani, G., Seeman, T. E., Matthews, K., et al. (2012). Race- and sex-specific associations of parental education with insulin resistance in middle-aged participants: The CARDIA study. European Journal of Epidemiology, 27(5), 349–355. PubMedCrossRef
Tarry-Adkins, J. L., & Ozanne, S. E. (2011). Mechanisms of early life programming: Current knowledge and future directions. The American Journal of Clinical Nutrition, 94(6 Supplement), 1765S–1771S. PubMedCrossRef
Taveras, E. M., Scanlon, K. S., Birch, L., Rifas-Shiman, S. L., Rich-Edwards, J. W., & Gillman, M. W. (2004). Association of breastfeeding with maternal control of infant feeding at age 1 year. Pediatrics, 114(5), e577–e583. PubMedCrossRef
Taveras, E. M., Rifas-Shiman, S. L., Oken, E., Gunderson, E. P., & Gillman, M. W. (2008). Short sleep duration in infancy and risk of childhood overweight. Archives of Pediatrics & Adolescent Medicine, 162(4), 305–311. CrossRef
Taveras, E. M., Gillman, M. W., Pena, M. M., Redline, S., & Rifas-Shiman, S. L. (2014). Chronic sleep curtailment and adiposity. Pediatrics, 133(6), 1013–1022. PubMedPubMedCentralCrossRef
Thayer, K. A., Heindel, J. J., Bucher, J. R., & Gallo, M. A. (2012). Role of environmental chemicals in diabetes and obesity: A National Toxicology Program workshop review. Environmental Health Perspectives, 120(6), 779–789. PubMedPubMedCentralCrossRef
Thompson, A. L., & Bentley, M. E. (2013). The critical period of infant feeding for the development of early disparities in obesity. Social Science & Medicine, 97, 288–296. CrossRef
Tounian, P. (2011). Programming towards childhood obesity. Annals of Nutrition & Metabolism, 58(Suppl 2), 30–41. CrossRef
Trevino, R. P., Yin, Z., Hernandez, A., Hale, D. E., Garcia, O. A., & Mobley, C. (2004). Impact of the Bienestar school-based diabetes mellitus prevention program on fasting capillary glucose levels: A randomized controlled trial. Archives of Pediatrics & Adolescent Medicine, 158(9), 911–917. CrossRef
Venditti, E. M., Elliot, D. L., Faith, M. S., Firrell, L. S., Giles, C. M., Goldberg, L., et al. (2009). Rationale, design and methods of the HEALTHY study behavior intervention component. International Journal of Obesity, 33(Suppl 4), S44–S51. PubMedCrossRef
Venkat Narayan, K. M., Boyle, J. P., Thompson, T. J., Sorensen, S. W., & Willimason, D. F. (2003). Lifetime risk for riabetes mellitus in the United States. JAMA, 290(14), 1884–1889. CrossRef
Versalovic, J. (2013). The human microbiome and probiotics: Implications for pediatrics. Annals of Nutrition & Metabolism, 63(Suppl 2), 42–52. CrossRef
Visscher, P. M., Hill, W. G., & Wray, N. R. (2008). Heritability in the genomics era–concepts and misconceptions. Nat Rev Genet, 9(4), 255–266. PubMedCrossRef
Wabitsch, M., Hauner, H., Hertrampf, M., Muche, R., Hay, B., Mayer, H., et al. (2004). Type II diabetes mellitus and impaired glucose regulation in Caucasian children and adolescents with obesity living in Germany. International Journal of Obesity and Related Metabolic Disorders, 28(2), 307–313. PubMedCrossRef
Waitzfelder, B., Pihoker, C., Klingensmith, G., Case, D., Anderson, A., Bell, R. A., et al. (2011). Adherence to guidelines for youths with diabetes mellitus. Pediatrics, 128(3), 531–538. PubMedPubMedCentral
Wang, L., Anderson, J. L., Dalton, W. T., Wu, T., Liu, X., & Zheng, S. (2013). Maternal depressive symptoms and the risk of overweight in their children. Maternal and Child Health Journal, 17(5), 940–948. PubMedCrossRef
Warner, M. J., & Ozanne, S. E. (2010). Mechanisms involved in the developmental programming of adulthood disease. The Biochemical Journal, 427(3), 333–347. PubMedCrossRef
Weiss, R., Taksali, S. E., Tamborlane, W. V., Burgert, T. S., Savoye, M., & Caprio, S. (2005). Predictors of changes in glucose tolerance status in obese youth. Diabetes Care, 28(4), 902–909. PubMedCrossRef
Wen, L. M., Baur, L. A., Simpson, J. M., Rissel, C., Wardle, K., & Flood, V. M. (2012). Effectiveness of home based early intervention on children’s BMI at age 2: Randomised controlled trial. BMJ, 344, e3732. doi: 10.​1136/​bmj.​e3732. PubMedPubMedCentralCrossRef
West, N. A., Hamman, R. F., Mayer-Davis, E. J., D’Agostino, R. B., Jr., Marcovina, S. M., Liese, A. S., et al. (2009). Cardiovascular risk factors among youth with and without type 2 diabetes: Differences and possible mechanisms. Diabetes Care, 32(1), 175–180. PubMedPubMedCentralCrossRef
Whitlock, E. P., O’Connor, E. A., Williams, S. B., Beil, T. L., & Lutz, K. W. (2010). Effectiveness of weight management interventions in children: A targeted systematic review for the US preventive service task Force. Pediatrics, 125(2), e396–e418. PubMedCrossRef
Whitmore, T. J., Trengove, N. J., Graham, D. F., & Hartmann, P. E. (2012). Analysis of insulin in human breast milk in mothers with type 1 and type 2 diabetes mellitus. International Journal of Endocrinology, 2012, 296368. doi: 10.​1155/​2012/​296368. PubMedPubMedCentralCrossRef
Zeitler, P. (2010). Approach to the obese adolescent with new-onset diabetes. The Journal of Clinical Endocrinology and Metabolism, 95(12), 5163–5170. PubMedPubMedCentralCrossRef
Zeitler, P., Hirst, K., Pyle, L., Linder, B., Copeland, K., Arslanian, S., et al. (2012). A clinical trial to maintain glycemic control in youth with type 2 diabetes. New England Journal of Medicine, 366(24), 2247–2256. CrossRef
Zeitler, P., Tandon, N., Nadeau, K., Urakami, T., Barrett, T., & Maahs, D. (2014). Type 2 diabetes in the child and adolescent. Pediatric Diabetes, 20(Supplement), 20–26.

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