Diabetes complications and comorbidities: Hypoglycemia

The addition of insulin glargine 300 units/mL to glucagon-like peptide-1 receptor agonist therapy in people with type 2 diabetes results in improved glycemic control without increasing risk for hypoglycemia, suggest findings from the real-world DELIVER-G study.

Adding daily empagliflozin to closed-loop insulin delivery improves time in range but also increases ketone levels in people with type 1 diabetes, shows a randomized trial.

Early findings from the Hypo-METRICS trial indicate that people with diabetes are unaware on most of the occasions that their blood glucose dips into the hypoglycemic range.

Implementing a subcutaneous insulin protocol for the treatment of diabetic ketoacidosis significantly reduces intensive care admissions and readmission to hospital within 30 days of discharge without increasing hypoglycemia, research shows.

Follow-up results from the WISDM trial show that extended use of continuous glucose monitoring leads to reduced hypoglycemia without increasing hyperglycemia risk in older people with type 1 diabetes.

Subcutaneous mini-dose glucagon reverses hypoglycemia more effectively than oral glucose tablets and helps adults with type 1 diabetes complete Ramadan fasts, shows a randomized crossover trial.

Researchers have identified 24 clinical and lifestyle variables associated with a significantly increased risk for severe hypoglycemia among people using insulin for type 2 diabetes.

Older adults with a longer duration of type 1 diabetes have an increased likelihood of experiencing depression and hypoglycemia unawareness, researchers report.

Individuals with type 1 diabetes continue to experience severe and level 2 hypoglycemia despite the use of continuous glucose monitoring systems, with the risk potentially influenced by personal beliefs, US research shows.

Researchers find that the type of benefits people with type 1 diabetes gain from hybrid closed-loop insulin delivery differs according to their baseline glycemic control.

Structured monitoring of blood glucose improves its control regardless of the device used, although continuous glucose monitoring is better than self-monitored blood glucose for reducing hypoglycemia, shows a randomized trial.

Diabetic ketoacidosis affects around one in 60 pregnant women with type 1 diabetes and is associated with “exceptionally high” perinatal mortality rates, shows research.

Young people with type 1 diabetes are at increased risk for hospitalization for acute complications at the time of transition from pediatric to adult care, say researchers.

A high rate of nonsevere hypoglycemic episodes is associated with risk for severe hypoglycemia, major adverse cardiovascular events, and mortality in people with type 2 diabetes, shows an analysis of LEADER data.

Intensification of diabetes medications in older adults at the point of discharge from hospital is associated with an increased risk for hypoglycemia, without gains in glycemic control, research suggests.

Children and adults with type 1 diabetes achieve significant reductions in glycated hemoglobin and hypoglycemic events during their first 90 days of using the Omnipod DASH insulin pump system, show real-world data.

The HARPdoc intervention is equivalent to Blood Glucose Awareness Training for reducing severe hypoglycemia in people with impaired awareness, and produces better mental health outcomes, report the trial investigators.

People with type 2 diabetes receiving the once-weekly basal insulin analog insulin icodec have similar hypoglycemic episode durations to those given insulin glargine, regardless of titration algorithm, initial loading dose, or prior insulin use, study findings indicate.

Findings from the Hypo-RESOLVE study suggest that exposure to hypoglycemia is associated with subsequent negative clinical outcomes in people with diabetes, supporting a key role for hypoglycemia prevention.

Diabetic ketoacidosis is three times more common with type 1 diabetes than with type 2 diabetes, but episode presentation and severity are similar between the two groups, show data presented at the virtual 57th EASD Annual Meeting.