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The CAROLINA trial

Update 06-11-2019CAROLINA shows neutral cardiovascular profile for modern sulfonylurea

Presenters: Julio Rosenstock, MD; Mark Espeland, PhD; Steven E. Kahn, MB, ChB; Nikolaus Marx, MD, FESC, FAHA; Bernard Zinman, CM, MD; Darren K. McGuire, MD, MHSc; Matthew C. Riddle, MD.

Monday 10 June: 16:30–18:30

CAROLINA (CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes) directly compared the cardiovascular safety/efficacy of linagliptin and glimepiride over a median follow-up of more than 6 years.

Thus, the findings will not only refine knowledge of the cardiovascular safety/efficacy of the dipeptidyl peptidase (DPP)-4 inhibitor class, but also help to clear up controversy surrounding the longer-term cardiovascular safety of sulfonylureas.

The trial sponsor has press-released the top-line findings, revealing that linagliptin was noninferior to glimepiride. The full results will be presented at ADA.