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Hypoglycemia

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03-14-2019 | Hypoglycemia | News

Real-world hypoglycemia data support continued sulfonylurea role in type 2 diabetes

Hypoglycemia is common among people being treated for type 2 diabetes, particularly those using insulin or a sulfonylurea, but the risk for severe episodes is only elevated among insulin users, suggest results of a prospective UK study.

03-12-2019 | Hypoglycemia | DUKPC 2019 | News

Nurse-led intervention can reduce mortality risk after severe hypoglycemia

Assigning people with type 2 diabetes to 3 months of focused care with a specialist diabetes nurse after an episode of severe hypoglycemia reduces their risk for mortality over the following few years, research shows.

02-28-2019 | Insulin | News

Real-world HbA1c targets usually individualized, rarely achieved

Real-world data show that people with type 2 diabetes struggle to attain their glycated hemoglobin targets, despite these commonly being individualized.

02-28-2019 | Hypoglycemia | ATTD 2019 | News

Rechecking flash glucose monitor within the hour halves risk for prolonged hypoglycemia

Research shows that if people with diabetes recheck their glucose levels within 1 hour after receiving a low blood glucose alert from their flash glucose monitor it substantially reduces their risk for experiencing a long period of hypoglycemia.

02-19-2019 | Ketoacidosis | Highlight | News

Data highlight opportunities to diagnose type 1 diabetes before DKA onset

Children with type 1 diabetes are more likely than their non-diabetic peers to seek primary care for a number of specific conditions in the year before their diagnosis, which could aid detection before the onset of diabetic ketoacidosis, say researchers.

02-12-2019 | SGLT2 inhibitors | Highlight | News

Recommendations issued for managing SGLT inhibitor-associated DKA risk in type 1 diabetes

Experts have developed consensus recommendations for minimizing diabetic ketoacidosis risk in patients with type 1 diabetes treated with SGLT inhibitors.

01-17-2019 | Glucokinase activators | Highlight | News

Hepatic glucokinase activation may improve glycemic control in type 2 diabetes

The hepatoselective glucokinase activator TTP399 reduces glycated hemoglobin levels without increasing the risk for hypoglycemia among patients with type 2 diabetes, suggest findings from the phase IIb AGATA trial.

10-04-2018 | Empagliflozin | EASD 2018 | News

EASE: Add-on empagliflozin improves glycemic control in type 1 diabetes

The addition of empagliflozin to insulin therapy reduces glycated hemoglobin levels in patients with type 1 diabetes, indicate findings from the phase III EASE-2 and 3 trials.

08-22-2018 | Insulin pumps | News

Predictive insulin-suspend algorithm cuts hypoglycemia without consequent hyperglycemia

The Tandem Basal-IQ predictive low-glucose suspend insulin delivery system significantly reduces the proportion of time adults and children spend in hypoglycemia during 24-hour usage, show findings from the randomized crossover PROLOG trial.

08-03-2018 | Adolescents | News

Diabetes care gaps at key age increase risk for complications

Almost half of young adults with type 1 diabetes do not see a diabetes physician for more than a year during their transition from pediatric to adult care, and this lack of contact is associated with an increased risk for complications, Canadian research shows.

07-31-2018 | Insulin pumps | News

Pros and cons of insulin pumps highlighted in young type 1 diabetes patients

Continuous subcutaneous insulin infusion therapy significantly lowers glycated hemoglobin levels in young people with type 1 diabetes, but at the cost of an increased risk for diabetic ketoacidosis during the first year, UK researchers report.

07-18-2018 | Sulfonylureas | Highlight | News

Continuing metformin advisable for patients starting sulfonylurea treatment

Research shows that starting second-line sulfonylurea treatment is associated with an increased risk for cardiovascular and hypoglycemic events among patients with type 2 diabetes in clinical practice, although the risk is less if they continue using metformin rather than switching completely.

07-10-2018 | Artificial pancreas systems | ADA 2018 | News

OpenAPS user glycemic data reported

Patients with type 1 diabetes who move to a DIY closed-loop insulin delivery system have significant improvements in their glycemic control, shows an analysis of continuous glucose monitoring data.

07-09-2018 | Insulin | News

Few efficacy and safety differences between long-acting insulins

The results of a network meta-analysis suggest that long-acting insulin analogs have broadly equivalent efficacy and safety in patients with type 2 diabetes, although some might be a little better for preventing nocturnal hypoglycemia.

07-03-2018 | Insulin | News

NPH insulin may be as good as analogs in type 2 diabetes

Patients with type 2 diabetes in clinical practice have similar outcomes regardless of whether they use long-acting insulin analogs or the cheaper human neutral protamine Hagedorn insulin, say researchers.

06-28-2018 | Dapagliflozin | ADA 2018 | News

DEPICT-2 confirms dapagliflozin efficacy in type 1 diabetes

The DEPICT-2 findings confirm those of DEPICT-1, with dapagliflozin producing improved glycemic control and weight loss, and reduced insulin need, in patients with type 1 diabetes.

06-27-2018 | Sotagliflozin | ADA 2018 | News

SGLT2 inhibitor benefits in type 1 diabetes persist over longer term

The DEPICT-1 and inTandem1 investigators have released their 52-week findings, revealing persistent reductions in glycated hemoglobin with SGLT2 inhibition, but a slightly increased risk for diabetic ketoacidosis.

06-24-2018 | Insulin degludec | ADA 2018 | News

Degludec benefits consistent in elderly patients

Degludec delivers the same magnitude of protection against hypoglycemia relative to glargine across patient age groups, shows analysis of the SWITCH 2 and DEVOTE trials.

06-24-2018 | Hypoglycemia | ADA 2018 | News

Post-CABG hypoglycemia may predict long-term mortality

Patients who experience hypoglycemia during intensive insulin therapy after coronary artery bypass graft surgery may be at increased risk for dying during the next year, suggests research presented at the ADA’s 78th Scientific Sessions.

06-24-2018 | Hypoglycemia | ADA 2018 | News

Impaired hypoglycemia ‘relatively common’ in insulin-dependent type 2 diabetes

Researchers have reported that around one in 10 patients with insulin-dependent type 2 diabetes have impaired hypoglycemia awareness.

06-23-2018 | Type 1 diabetes | ADA 2018 | News

Timing of insulin suspension pre-exercise affects hypoglycemia risk

Reducing basal insulin in people with type 1 diabetes by 50–80% 90 minutes before exercise results in significantly smaller falls in blood glucose than suspending insulin at exercise onset, shows research presented at ADA’s 78th Scientific Sessions in Orlando, Florida.

06-23-2018 | Children | ADA 2018 | News

Pubertal status affects glycemic variability in children with type 1 diabetes

Prepubertal children with type 1 diabetes have greater glycemic variability than those who are pubertal or postpubertal, researchers have reported at the ADA’s 78th Scientific Sessions.

06-13-2018 | Ketoacidosis | Highlight | News

Fluid management strategy absolved of neurologic injury blame in childhood DKA

Neither the rate of administration nor the sodium chloride content of replacement fluids given to children with diabetic ketoacidosis influences their neurologic outcomes, show the results of the PECARN DKA FLUID Study.

05-25-2018 | Hypoglycemia | Highlight | News

Mini-dose glucagon could help protect against exercise-induced hypoglycemia

Modestly increasing glucagon levels when commencing physical activity could be an effective strategy for preventing exercise-induced hypoglycemia among patients with type 1 diabetes, results of a randomized crossover trial suggest.

05-23-2018 | Hypoglycemia | Highlight | News

Ambulance contacts for hypoglycemia ‘a missed opportunity’ to improve care

Ambulance call-outs for episodes of severe hypoglycemia do not consistently result in reviews of patients’ care, despite guideline recommendations, shows a study of diabetes patients in England and Wales.

05-17-2018 | Hypoglycemia | Highlight | News

TRIMECO puts islet transplantation on solid ground when insulin fails

The first randomized trial of islet transplantation supports its use in patients with severe, unstable type 1 diabetes.

05-16-2018 | Artificial pancreas systems | News

Glucagon in closed-loop system guards against exercise-induced hypoglycemia

Using a dual-hormone closed-loop insulin delivery system that detects when the wearer is doing exercise results in a low rate of exercise-induced hypoglycemia, show findings from a small randomized study.

05-15-2018 | Hypoglycemia | News

Global differences reported for hypoglycemia-related deaths

Researchers have highlighted variation in the burden of hypoglycemia-related deaths worldwide, with the highest rates observed in Central and South America and the Caribbean.

04-26-2018 | Transitions of care | News

Transition to university challenging for students with type 1 diabetes

Students with type 1 diabetes report increased difficulties with managing their condition when they start at university, with consequences for glycemic control and acute complications.

04-23-2018 | Hypoglycemia | News

Education effects on hypoglycemia awareness persist in long term

Follow-up of the HypoCOMPaSS trial shows that the improvements achieved from a brief hypoglycemia awareness intervention and 6 months of regular support remain apparent 2 years after baseline.

04-18-2018 | Artificial pancreas systems | News

Data support artificial pancreas for type 1 diabetes, but better evidence needed

Analysis of the research to date comparing artificial pancreas treatment with other insulin systems supports its ability to significantly improve glycemic control in patients with type 1 diabetes, while reducing the burden of hypoglycemia.

04-13-2018 | Healthcare systems | News

Regular healthcare access may reduce children’s DKA risk at diabetes diagnosis

Children are less likely to present with diabetic ketoacidosis at the time of type 1 diabetes diagnosis if they previously had regular access to a healthcare provider, research published in CMAJ suggests.

04-03-2018 | Alogliptin | Highlight | News

Support for alogliptin as add-on therapy for type 2 diabetes

Adding the dipeptidyl peptidase-4 inhibitor alogliptin to metformin and sulfonylurea treatment may improve glycemic control in patients with type 2 diabetes and high cardiovascular risk, a post-hoc analysis of the EXAMINE trial suggests.

03-28-2018 | Hypoglycemia | News

Predictors of severe hypoglycemia in type 2 diabetes identified

The incidence of severe hypoglycemia in patients with type 2 diabetes has increased over time and may be predicted by previous nonsevere hypoglycemic episodes, data from a large integrated healthcare system in the USA show.

03-15-2018 | Liraglutide (T2DM) | News

Liraglutide associated with decreased risk for severe hypoglycemia

A post-hoc analysis of the LEADER trial indicates that liraglutide treatment may reduce the risk for severe hypoglycemia among patients with type 2 diabetes.

02-19-2018 | Continuous glucose monitoring | Highlight | News

HypoDE: CGM reduces hypoglycemia in high-risk patients using MDI

The HypoDE investigators have reported that use of continuous glucose monitoring results in large reductions in hypoglycemia among high-risk patients managing their type 1 diabetes with multiple daily injections.

02-16-2018 | Flash glucose monitoring | News

Hypoglycemia improvements seen with flash to CGM switch

Further findings from the pilot I-HART randomized trial suggest that switching from flash to continuous glucose monitoring reduces the time patients with type 1 diabetes spend in hypoglycemia

02-16-2018 | Flash glucose monitoring | News

Flash monitoring benefits backed up by real-world data

Flash glucose monitoring confers similar benefits for diabetes patients in the real world as for those using it in clinical trials, research shows.

02-15-2018 | Diet | News

Hypoglycemia rate ‘lower-than-expected’ with intermittent fasting diet

Intermittent fasting, following a 5:2 pattern alongside weekly diabetes supervision and reduced medication, doubles the likelihood of experiencing hypoglycemia on fasting days in obese individuals with type 2 diabetes, study data show.

02-02-2018 | Disordered eating | News

Diet quality intervention does not trigger disordered eating in adolescents

Research shows that intervening to improve the diet quality of adolescents with type 1 diabetes does not exacerbate disordered eating behavior.

01-23-2018 | Continuous glucose monitoring | News

Real-world CGM data support better outcomes in type 1 diabetes

Research shows that continuous glucose monitoring reduces hypoglycemia risk and improves patient-reported outcomes among people with type 1 diabetes in real-world practice.

01-22-2018 | Hypoglycemia | News

Bidirectional relationship evident between severe hypoglycemia and CV events

An analysis of TECOS data highlights a bidirectional relationship between severe hypoglycemic events and adverse cardiovascular outcomes in patients with type 2 diabetes.

01-09-2018 | Hypoglycemia | News

Weight-based glucose best for tackling hypoglycemia in pump users

Taking a weight-based dose of glucose resolves hypoglycemia more effectively than taking a standard fixed dose for type 1 diabetes patients using an insulin pump, show the results of a randomized crossover trial.

01-03-2018 | Glucagon | News

Glucagon use restrictions compromising prehospital hypoglycemia treatment in USA

The widespread bar on glucagon administration by basic providers of emergency medicine in the USA may prevent its use in three-quarters of cases in which it is needed, say researchers.

12-22-2017 | Depression | News

Depression and severe dysglycemia increase the risk for each other

A bidirectional relationship between depression and severe dysglycemia exists among older people with type 1 diabetes, indicating a need for increased vigilance in this population.

12-19-2017 | Hypoglycemia | News

CGM may be better than flash for impaired hypoglycemia awareness

A pilot randomized study suggests that continuous glucose monitoring may be better than flash monitoring for reducing hypoglycemia in type 1 diabetes patients with impaired awareness.

12-18-2017 | Hypoglycemia | News

Severe hypoglycemia risk remains high years after previous episode in children with diabetes

The risk of having a repeat episode of severe hypoglycemia is elevated for at least 4 years after a previous episode in children with type 1 diabetes, although the risk is highest during the first year, researchers report.

12-14-2017 | Hypoglycemia | News

Automatic insulin pump suspension reduces hypoglycemia in adolescents with diabetes

Children and adolescents with type 1 diabetes using a predictive low-glucose management system have less hypoglycemia and fewer hypoglycemic events than those managed using sensor-augmented pump therapy alone, according to a 6-month trial.

11-30-2017 | Hypoglycemia | News

Hypoglycemia awareness intervention not cost-effective

Researchers have determined that the partly online HypoAware intervention, although clinically effective, is not cost-effective.

10-24-2017 | Sulfonylureas | News

First-line sulfonylureas may increase hypoglycemia risk in type 2 diabetes

Patients initiating treatment for type 2 diabetes with sulfonylureas are more than four times as likely to be hospitalized with hypoglycemia as those treated with metformin, population-based study data show.

10-10-2017 | Insulin pumps | News

Real-world data support reduced hypoglycemia risk in young pump users

Findings from a population-based study indicate that insulin pump use is associated with reduced risks for severe hypoglycemia and diabetic ketoacidosis in children, adolescents, and young adults with type 1 diabetes.

09-28-2017 | Hypoglycemia | News

Ambiguous symptoms may disguise hypoglycemia in elderly patients

Research suggests that older diabetes patients, particularly those using insulin, often have nonspecific symptoms of hypoglycemia that are overlooked by healthcare providers.

09-22-2017 | Older adults | EASD 2017 | News

Optimizing outcomes: System and patient factors

An EASD session on optimizing patient outcomes included research into the effect of guideline adherence, predictors of changes in medication adherence, and overtreatment of older people with diabetes.

09-22-2017 | Insulin glargine | EASD 2017 | News

Higher dose of insulin glargine supported for type 2 diabetes

Results of a pooled analysis suggest that the 300 U/mL dose of insulin glargine is associated with a lower risk for hypoglycemia than the 100 U/mL dose.

09-20-2017 | Hypoglycemia | EASD 2017 | News

Hypoglycemia: Risk factors and Ramadan

Results presented during an EASD annual meeting session on hypoglycemia covered risk factors and consequences, and looked at the optimal insulin management approach for diabetes patients wishing to observe Ramadan.

09-19-2017 | Sotagliflozin | EASD 2017 | News

Sotagliflozin as adjunct therapy to insulin ‘might be a treatment option’ for type 1 diabetes

Sotagliflozin may be an effective add-on therapy to insulin for patients with type 1 diabetes, but the benefits are less clear in a young adult population, suggest the results of two studies presented at the EASD annual meeting in Lisbon, Portugal.

09-15-2017 | Hypoglycemia | EASD 2017 | News

Glycemic variability, hypoglycemia linked to poor outcomes in type 2 diabetes patients

Two secondary analyses of the DEVOTE trial suggest that type 2 diabetes patients with high day-to-day fasting glycemic variability and those who experience severe hypoglycemia are at increased risk for adverse outcomes.

09-14-2017 | Dapagliflozin | EASD 2017 | News

DEPICT-1 findings support dapagliflozin as add-on therapy for type 1 diabetes

Dapagliflozin is a promising adjunct treatment to insulin for patients with type 1 diabetes, suggest phase III trial results presented at the EASD annual meeting in Lisbon, Portugal, and published simultaneously in The Lancet Diabetes & Endocrinology.

09-14-2017 | Type 1 diabetes | EASD 2017 | News

Add-on sotagliflozin improves glycemic control in type 1 diabetes patients

Results of the inTandem3 study suggest that adding the sodium–glucose cotransporter 1 and 2 inhibitor sotagliflozin to insulin treatment improves glycemic control among patients with type 1 diabetes, but at the cost of an increased risk for ketoacidosis.

09-13-2017 | GLP-1 agonists | EASD 2017 | News

Incretins research update

One of the first original research sessions of EASD 2017 included updates from the TECOS, SUSTAIN 6, and DURATION-7 and -8 trials.

08-16-2017 | Lifestyle interventions | News

Lifestyle intervention has modest impact on glycemic control in type 2 diabetes

Adding an intensive lifestyle intervention to usual care slightly improves glycemic control but substantially reduces the need for glucose-lowering medication among patients with non–insulin-dependent type 2 diabetes, suggest trial results published as a preliminary communication in JAMA.

07-21-2017 | Insulin pumps | News

Mixed results from adding insulin pump to CGM in type 1 diabetes

A analysis from the DIAMOND trial suggests that adding an insulin pump to continuous glucose monitoring leads to better glycemic control, but at the price of more hypoglycemia.

Read the linked commentary from Leonard Bertheau.

07-12-2017 | Ketoacidosis | News

Ketoacidosis at type 1 diabetes diagnosis predicts poor long-term glycemic control

A study has found that children with diabetic ketoacidosis at the diagnosis of type 1 diabetes have poor long-term glycemic control, independent of established demographic and socioeconomic risk factors.

07-03-2017 | Insulin degludec | News

SWITCH studies support reduced hypoglycemia risk with insulin degludec

Head-to-head trials of the ultralong-acting insulin degludec versus insulin glargine U100 show that the former significantly reduces the risk for hypoglycemia in patients with type 1 and type 2 diabetes.

06-16-2017 | Insulin degludec | ADA 2017 | News

DEVOTE: degludec offers CV equivalence and hypoglycemic superiority to glargine

The ultralong-acting, once-daily basal insulin degludec has equivalent cardiovascular safety to that of insulin glargine and reduces hypoglycemia risk in patients with type 2 diabetes, the DEVOTE investigators have reported.

06-07-2017 | SGLT2 inhibitors | News

SGLT2 inhibitor initiation linked to raised diabetic ketoacidosis risk

Research findings indicate that patients with type 2 diabetes may have an increased risk for diabetic ketoacidosis when they begin treatment with a sodium–glucose cotransporter 2 inhibitor.

05-19-2017 | Sulfonylureas | News

Hypoglycemia associated with cardiovascular risk among sulfonylurea users

Patients with type 2 diabetes who experience hypoglycemia during sulfonylurea treatment are at greater risk for cardiovascular events than those who do not experience hypoglycemia, results of a US study suggest.

04-17-2017 | Metformin | News

Early glycemic control key after metformin initiation

Patients with type 2 diabetes who experience a large reduction in glycated hemoglobin levels within 6 months of starting metformin therapy have a lower risk for adverse outcomes than those who do not achieve early glycemic control, study results suggest.

04-10-2017 | Continuous glucose monitoring | News

CGM could improve quality of life in patients with type 1 diabetes

Continuous glucose monitoring is associated with improvements in diabetes-specific quality of life compared with self-monitoring among patients with type 1 diabetes who use multiple daily insulin injections, study results suggest.

04-07-2017 | Continuous glucose monitoring | News

Predictive system reduces hypoglycemia burden in children with type 1 diabetes

Research suggests that a predictive low-glucose management system significantly reduces hypoglycemic events in children and adolescents with type 1 diabetes.

04-05-2017 | Insulin aspart | News

Fast-acting insulin aspart offers promising glycemic control

Results of the Onset 1 trial confirm that treatment with fast-acting insulin aspart provides improves glycemic control compared with conventional insulin aspart among adults with type 1 diabetes.

03-30-2017 | Ketoacidosis | News

Acute kidney injury common in pediatric diabetic ketoacidosis

Almost two-thirds of children hospitalized with diabetic ketoacidosis develop acute kidney injury within 24 hours of hospitalization, study findings indicate.

03-27-2017 | Inpatient diabetes | News

Remote monitoring may improve diabetes inpatient care

A study suggests that use of a virtual glucose management service can reduce hyper- and hypoglycemia among inpatients with diabetes by around a third.

03-17-2017 | Hypoglycemia | News

ARIC analysis highlights hypoglycemia risks

Analysis of the population-based ARIC cohort supports an association between severe hypoglycemia and both cardiovascular disease and mortality in patients with diabetes.

03-01-2017 | Hypoglycemia | News

Increased QT dynamicity during hypoglycemia cause for concern

Hypoglycemia is associated with increased nocturnal QT dynamicity in patients with well-controlled sulfonylurea-treated type 2 diabetes, Australian researchers report.

02-23-2017 | Lixisenatide | News

GetGoal-O supports lixisenatide use for older patients with type 2 diabetes

Results of the placebo-controlled GetGoal-O trial suggest that adding lixisenatide to existing diabetes treatment improves glycemic control among nonfrail older patients with uncontrolled type 2 diabetes.

02-17-2017 | Continuous glucose monitoring | News

Findings support standalone use of CGM in well-controlled type 1 diabetes

Results of a randomized trial suggest that continuous glucose monitoring can be used without regular confirmatory blood glucose monitoring among adult insulin pump users with well-controlled type 1 diabetes.

02-09-2017 | Ketoacidosis | News

Neonatal diabetes complications can have profound impact

Researchers report two cases of children with severe and irreversible neurologic damage caused by complications at the time of neonatal diabetes diagnosis, highlighting the need for increased awareness of the condition.

02-03-2017 | Ketoacidosis | News

Type 1 diabetes patients lax about testing ketones

A large survey highlights that patients with type 1 diabetes are poorly compliant with self-monitoring their ketone levels when needed, leading the researchers to urge better education on the subject.

01-24-2017 | Continuous glucose monitoring | News

CGM could aid glycemic control with multiple daily insulin injections

Two clinical trials published in JAMA show that continuous glucose monitoring can improve glycemic control in patients with type 1 diabetes who take insulin by means of multiple daily injections.

01-05-2017 | Hypoglycemia | News

Glucose variability dependent on diabetes type and treatment

Glucose variability rises with increasingly insulin-dependent forms of diabetes, report researchers.

12-02-2016 | Hypoglycemia | News

Adjunct canagliflozin improves glycemic variability in type 1 diabetes

Canagliflozin improves glycemic variability and treatment satisfaction in patients with type 1 diabetes using the sodium glucose cotransporter 2 inhibitor as an add-on to insulin, show findings from a randomized trial.

10-27-2016 | Hypoglycemia | News

Promising results for hypoglycemia awareness intervention

A partly web-based hypoglycemia awareness group intervention shows promising results in a randomized controlled trial.

10-26-2016 | Complications | News | Article

Causes of death defined in young adults with type I diabetes

Mortality rates are high among adolescents and young adults with type I diabetes, with more than half caused by acute or chronic complications, researchers report.

09-16-2016 | Continuous glucose monitoring | News | Article

Continuous glucose monitoring hopeful for hypoglycaemia unaware patients

The IN CONTROL trial demonstrates that continuous glucose monitoring improves glycaemic control in Type 1 diabetes patients who have hypoglycaemia unawareness.

09-15-2016 | Hypoglycemia | News | Article

Hypoglycaemia link to myocardial damage bolstered

Elevated levels of high-sensitivity cardiac troponin T are common in diabetes patients with a history of severe hypoglycaemia, show data from the ARIC study.

09-15-2016 | Flash glucose monitoring | News | Article

‘Flash’ glucose sensor reduces glucose variability in Type 1 diabetes

“Flash” glucose monitoring reduces the time adults with Type 1 diabetes spend in a hypoglycaemic state by about a third, research shows.

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