Type 2 diabetes and hypoglycemia

Result from ONWARDS 5 trial show weekly insulin icodec plus a dosing app offers greater reductions in glycated hemoglobin than daily basal insulin analogs for type 2 diabetes.

The results of ONWARDS 2 show significantly improved glycemic control with weekly insulin icodec versus daily insulin degludec, without significantly increased hypoglycemia, in people with type 2 diabetes.

A health informatics system based on routine clinical data helps physicians to prioritize high-risk people with diabetes, deliver more equitable care, and manage healthcare capacity, report researchers.

People taking basal insulin to treat type 2 diabetes experience a significant reduction in the risk for acute complications, which is sustained for at least 2 years after initiating use of the Freestyle Libre, say French researchers.

The risk for hypoglycemia from an accidental basal insulin overdose is no higher with weekly insulin icodec than with daily glargine U100 in people with type 2 diabetes, report researchers.

Women are more likely than men to experience repercussions of serious or severe hypoglycemia that impact their wellbeing or diabetes management, a study suggests.

The addition of insulin glargine 300 units/mL to glucagon-like peptide-1 receptor agonist therapy in people with type 2 diabetes results in improved glycemic control without increasing risk for hypoglycemia, suggest findings from the real-world DELIVER-G study.

Early findings from the Hypo-METRICS trial indicate that people with diabetes are unaware on most of the occasions that their blood glucose dips into the hypoglycemic range.

Implementing a subcutaneous insulin protocol for the treatment of diabetic ketoacidosis significantly reduces intensive care admissions and readmission to hospital within 30 days of discharge without increasing hypoglycemia, research shows.

Researchers have identified 24 clinical and lifestyle variables associated with a significantly increased risk for severe hypoglycemia among people using insulin for type 2 diabetes.

Structured monitoring of blood glucose improves its control regardless of the device used, although continuous glucose monitoring is better than self-monitored blood glucose for reducing hypoglycemia, shows a randomized trial.

Diabetic ketoacidosis affects around one in 60 pregnant women with type 1 diabetes and is associated with “exceptionally high” perinatal mortality rates, shows research.

Young people with type 1 diabetes are at increased risk for hospitalization for acute complications at the time of transition from pediatric to adult care, say researchers.

A high rate of nonsevere hypoglycemic episodes is associated with risk for severe hypoglycemia, major adverse cardiovascular events, and mortality in people with type 2 diabetes, shows an analysis of LEADER data.

Intensification of diabetes medications in older adults at the point of discharge from hospital is associated with an increased risk for hypoglycemia, without gains in glycemic control, research suggests.

People with type 2 diabetes receiving the once-weekly basal insulin analog insulin icodec have similar hypoglycemic episode durations to those given insulin glargine, regardless of titration algorithm, initial loading dose, or prior insulin use, study findings indicate.

Findings from the Hypo-RESOLVE study suggest that exposure to hypoglycemia is associated with subsequent negative clinical outcomes in people with diabetes, supporting a key role for hypoglycemia prevention.

Diabetic ketoacidosis is three times more common with type 1 diabetes than with type 2 diabetes, but episode presentation and severity are similar between the two groups, show data presented at the virtual 57th EASD Annual Meeting.

Researchers find the increase in hospital admissions for diabetic ketoacidosis in England during the COVID-19 pandemic was caused by additional admissions of people with new-onset or type 2 diabetes.

Ambulance crews may be able to reduce the likelihood for repeat callouts to people with severe hypoglycemia by offering them advice and a leaflet on avoiding a second episode, a study suggests.