Diabetic foot

Prospective Studies Collaboration and Asia Pacific Cohort Studies Collaboration. Lancet Diabetes Endocrinol 2018; Advance online publication. doi: 10.1016/S2213-8587(18)30079-2

Zamani-Alavijeh F et al. Diabetol Metab Syndr 2018; 10: 39. doi: 10.1186/s13098-018-0342-5

Lapolla A, Metzger BE. Acta Diabetol 2018; Advance online publication. doi: 10.1007/s00592-018-1146-7

Researchers report that use of an ankle-high removable cast walker, paired with an external lift on the other shoe, improves patients’ comfort and could therefore lead to better adherence, resulting in improved healing of diabetic foot ulcers.

A wound dressing that generates nitric oxide improves the healing of diabetic foot ulcers, relative to standard care, show the findings of a randomized trial.

Hjort R et al. Diabetologia 2018; 61: 1333–1343. doi: 10.1007/s00125-018-4596-0

Li SX et al. Diabetologia 2018; 61: 1325–1332. doi: 10.1007/s00125-018-4586-2

With the 2017 NaDIA results showing some positive trends in inpatient diabetes care, medwireNews talks to national clinical lead Gerry Rayman about the tools and tactics to deliver the best patient outcomes.

Sortsø C et al. Diabetologia 2018; 61: 1306–1314. doi: 10.1007/s00125-018-4594-2

Findings from the Explorer trial show that a sucrose octasulfate dressing improves wound closure of neuroischemic diabetic foot ulcers relative to a standard dressing.

Hyperbaric oxygen therapy does not significantly improve wound healing or reduce major amputation rates when added to usual care in patients with diabetes and ischemic lower extremity ulcers, Dutch study data show.

A composite algorithm including the calprotectin biomarker can help physicians decide whether a diabetic foot ulcer needs antibiotic therapy, say researchers.

The integrated results of the CANVAS and CANVAS-R studies show that canagliflozin reduces the risk for cardiovascular and renal events in patients with type 2 diabetes at high cardiovascular risk.

Study findings suggest that the current annual incidence of diabetic foot may be lower than previously reported in the 1990s, despite the prevalence of diabetes nearly doubling in that time.