Artificial pancreas systems

A dual-hormone fully closed-loop system did not demonstrate non-inferiority to a hybrid system in a randomized trial, despite producing a high time in range, report the researchers.

Closed-loop control with the Cambridge hybrid system improves time in range in very young children with type 1 diabetes relative to sensor-augmented pump delivery over 16 weeks of use, researchers report.

Findings from an exploratory randomized crossover trial suggest that closed-loop insulin delivery leads to better glycemic control than standard insulin treatment in people with type 2 diabetes and end-stage renal disease requiring maintenance dialysis in the outpatient setting.

The Cambridge closed-loop insulin delivery system significantly improves glycemic control during 6 months of use by children and adolescents compared with standard insulin pump therapy, report the DAN05 investigators.

Use of the Omnipod 5 closed-loop insulin delivery system reduces diabetes distress and improves quality of life, particularly for the carers of children with type 1 diabetes, research shows.

The Omnipod 5 tubeless automated insulin delivery system improves glycemic outcomes of very young children with type 1 diabetes and the sleep of their caregivers, report researchers.

A closed-loop system with an artificial intelligence component that rapidly detects when the user is eating a meal may offer a route towards fully closed-loop insulin delivery, shows a small crossover trial in adolescents and young adults.

A consensus statement covering the practical, ethical, and legal aspects of the use of open-source closed-loop insulin delivery algorithms is soon to be published, the authors reported at the virtual ATTD 2021 conference.

A large real-world study shows improved glycemic outcomes for adults and children who initiate use of the Loop DIY automated insulin delivery system using community resources.

Among people with type 1 diabetes, adding the SGLT2 inhibitor empagliflozin to an automated insulin delivery system may allow replacement of carbohydrate counting with a simple meal announcement, suggest findings from a pilot randomized trial.

A closed-loop insulin delivery system may offer significantly better glycemic control than an open-loop system with predictive low glucose suspend in islet transplant candidates with highly unstable type 1 diabetes, research shows.

A fully automated dual-hormone delivery system with pramlintide and faster-acting insulin aspart delivers overall glycemic control that is nearly as good as that achieved with a hybrid closed-loop system with the insulin only, report researchers at the virtual 56th EASD Annual Meeting.

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Children with type 1 diabetes who use the Tandem Control-IQ hybrid closed-loop insulin delivery system spend more time with their blood glucose levels in the target range than those using a sensor-augmented insulin pump, show findings from the iDCL trial.

Engineer turned endocrinologist Rayhan Lal reflects on the shape of artificial pancreas research and what changes are needed to best benefit people with diabetes (18:54).

The Omnipod Horizon closed-loop system has delivered good glucose control in its first outpatient study, the investigators report.

The Medtronic MiniMed Advanced Hybrid Closed-Loop system delivers better glycemic control than the currently approved 670G system, shows the international FLAIR trial.

Healthcare professionals can make false assumptions about which children with type 1 diabetes will gain most from closed-loop insulin delivery, risking children who could potentially benefit missing out, research suggests.

A novel artificial pancreas that delivers both rapid insulin and pramlintide improves glycemic control compared with one that delivers rapid insulin alone, without increasing hypoglycemia rates, in people with type 1 diabetes, Canadian research shows.

A randomized trial shows the feasibility of closed-loop insulin delivery controlled by an algorithm on a user’s phone rather than in their pump, but also highlights issues with connectivity.