Analysis of the Relationship Between Zinc Deficiency, Androgen Disorders, and Lung

Ciminari, María Eugenia; Pérez Chaca, María Verónica; Álvarez, Silvina Mónica; Biaggio, Verónica Silvina; Gómez, Nidia Noemí

doi:10.1007/978-3-319-40007-5_90-1

María Eugenia Ciminari³,
María Verónica Pérez Chaca³,
Silvina Mónica Álvarez³,
Verónica Silvina Biaggio³ &
…
Nidia Noemí Gómez³

341 Accesses

Abstract

This review is focused on the adult lung in health and disease and the effect of zinc on both states. Pulmonary fibrosis (PF), chronic obstructive pulmonary disease (COPD), and asthma are some of the major health problems in the world. Zn is present in protein-bound and ionic forms, and plays important roles in mediating the function and structure of proteins, and in maintaining physiological homeostasis. It was found that zinc is involved in the regulation of sex hormones and that it also has effects on lung lipid metabolism and the immune system. It is known that sex affects lung development and physiology. Androgens enhance airway branching but delay alveolar maturation contributing to increased respiratory morbidity in prematurely born male infants. It was shown that there are sex-specific trends in the incidence, prevalence, and mortality of diseases, such as COPD and PF. In men, there is a gradual decline in testosterone secretion that begins after 30 years old, with the signs and symptoms of testosterone deficiency typically presenting after the age of 65. The absence of androgens induces oxidative stress and lipid peroxidation in lung, synchronically with changes in the expression of cytoprotective markers, what could be part of the mechanisms involved in the development of the previously mentioned diseases. Therefore, not only the levels of zinc, but also of testosterone are important in order to maintain the lungs healthy and functional.

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Abbreviations

AE2:: Alveolar epithelial type II
AECs:: Alveolar epithelial cells
AR:: Androgen receptors
ARKO:: AR knocks out
ASM:: Airway smooth muscle
BHR:: Bronchial hyperresponsiveness
CAT:: Catalase
COPD:: Chronic obstructive pulmonary disease
COX-2:: Ciclooxigenase 2
DHT:: Dihydrotestosterone
ECM:: Extracellular matrix
EMT:: Epithelial–mesenchymal transition
ER:: Endoplasmic reticulum
GD17:: Gestational day 17
GPx:: Glutathione peroxidase
Hoxb5:: Hox protein b5
Hsp27:: Heat shock protein 27
Hsp70:: Heat shock protein 70
IL-8:: Interleukin-8
IPF:: Idiopathic pulmonary fibrosis
LTB4:: Leukotriene B4
MUC5B:: Common genetic variant in mucin 5B
NF-κB:: Nuclear factor κB
NOX:: NADPH oxidase
PF:: Pulmonary fibrosis
RCC:: Renal cell carcinoma
RT:: Radiotherapy
SMAD2P:: Smad protein 2P
SMAD7:: Smad protein 7
SPA:: Surfactant protein A
SPC:: Surfactant protein C
TBARS:: Thiobarbituric acid reactive substances
TERC:: Telomerase RNA component
TERT:: Telomerase reverse transcriptase
TNF-a:: Tumor necrosis factor-a
UPR:: Unfolded protein response
Zn:: Zinc

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Departamento de Bioquímica y Ciencias Biológicas, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, IMIBIO-CONICET , San Luis, Argentina
María Eugenia Ciminari, María Verónica Pérez Chaca, Silvina Mónica Álvarez, Verónica Silvina Biaggio & Nidia Noemí Gómez

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María Eugenia Ciminari
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María Verónica Pérez Chaca
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Silvina Mónica Álvarez
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Verónica Silvina Biaggio
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Nidia Noemí Gómez
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Correspondence to Nidia Noemí Gómez .

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Diabetes & Nutritional Sci Div Sch, King's College London, London, United Kingdom
Victor Preedy
Clinical Biochemistry, University of Westminster, Westminster, United Kingdom
Vinood B. Patel

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Ciminari, M.E., Pérez Chaca, M.V., Álvarez, S.M., Biaggio, V.S., Gómez, N.N. (2018). Analysis of the Relationship Between Zinc Deficiency, Androgen Disorders, and Lung. In: Preedy, V., Patel, V. (eds) Handbook of Famine, Starvation, and Nutrient Deprivation. Springer, Cham. https://doi.org/10.1007/978-3-319-40007-5_90-1

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DOI: https://doi.org/10.1007/978-3-319-40007-5_90-1
Received: 03 October 2017
Accepted: 03 October 2017
Published: 14 October 2017
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-40007-5
Online ISBN: 978-3-319-40007-5
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