Semin Musculoskelet Radiol 2016; 20(04): 330-344
DOI: 10.1055/s-0036-1592434
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Nonspinal Fragility Fractures

Maria Pilar Aparisi Gómez
1   Department of Radiology, Auckland District Health Board, Auckland City Hospital, Greenlane Clinical Center, National Women's Hospital, Auckland, New Zealand
2   Department of Radiology, Hospital Nueve de Octubre, Valencia, Spain
› Author Affiliations
Further Information

Publication History

Publication Date:
14 November 2016 (online)

Abstract

This article focuses on nonspinal fragility or insufficiency fractures. Fragility fractures occur when normal levels of energy are applied to weakened bone, and they normally represent spontaneous fractures or traumatic fractures from minimal energy trauma that would not normally result in fracture in healthy people. This is the case in osteoporosis, where there is reduction of bone mass as well as loss of normal trabecular architecture leading to changes in structural characteristics that compromise biomechanics.

The prevalence and most common locations, as well as clinical and diagnostic aspects, of nonspinal fragility fractures are presented. Osteoporosis is highly prevalent and can have different causes. The most common ones are primary, such as postmenopausal and senile osteoporosis, and secondary to several causes.

Clinically, patients with insufficiency fractures present with pain, in many cases severe, and usually no history of trauma or eventually a history of minor trauma, such as a fall from standing height. If some cases, when these fractures are not displaced, detection is a challenge. In other cases, due to their location and equivocal features, differential diagnosis with malignancy has to be made. Radiographs, magnetic resonance imaging, multidetector computed tomography, positron emission tomography-computed tomography, and radionuclide scans have diverse roles in the diagnosis of insufficiency fractures.

 
  • References

  • 1 Guglielmi G, Muscarella S, Bazzocchi A. Integrated imaging approach to osteoporosis: state-of-the-art review and update. Radiographics 2011; 31 (5) 1343-1364
  • 2 Center JR, Bliuc D, Nguyen TV, Eisman JA. Risk of subsequent fracture after low-trauma fracture in men and women. JAMA 2007; 297 (4) 387-394
  • 3 Ettinger B, Ray GT, Pressman AR, Gluck O. Limb fractures in elderly men as indicators of subsequent fracture risk. Arch Intern Med 2003; 163 (22) 2741-2747
  • 4 Lindsay R, Silverman SL, Cooper C , et al. Risk of new vertebral fracture in the year following a fracture. JAMA 2001; 285 (3) 320-323
  • 5 Kanis JA, Johnell O, De Laet C , et al. A meta-analysis of previous fracture and subsequent fracture risk. Bone 2004; 35 (2) 375-382
  • 6 Klotzbuecher CM, Ross PD, Landsman PB, Abbott III TA, Berger M. Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Miner Res 2000; 15 (4) 721-739
  • 7 Schousboe JT, Fink HA, Lui LY, Taylor BC, Ensrud KE. Association between prior non-spine non-hip fractures or prevalent radiographic vertebral deformities known to be at least 10 years old and incident hip fracture. J Bone Miner Res 2006; 21 (10) 1557-1564
  • 8 Kanis JA, Burlet N, Cooper C , et al; European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int 2008; 19 (4) 399-428
  • 9 Bouxsein ML, Karasik D. Bone geometry and skeletal fragility. Curr Osteoporos Rep 2006; 4 (2) 49-56
  • 10 Kaufmann RP, Overton TH, Shiflett M, Jennings JC. Osteoporosis in children and adolescent girls: case report of juvenile osteoporosis and review of the literature. Obstet Gynecol Surg 2001; 56: 492-504
  • 11 Fitzpatrick LA. Secondary causes of osteoporosis. Mayo Clin Proc 2002; 77 (5) 453-468
  • 12 Adams JE. Metabolic and endocrine skeletal disease. In: Grainger RG, Allison DJ, Dixon EK, eds. Grainger and Allison's Diagnostic Radiology: A Textbook of Clinical Imaging. 5th ed. Philadelphia, PA: Churchill Livingstone; 2008: 1043-1113
  • 13 Toms AP, Marshall TJ, Becker E, Donell ST, Lobo-Mueller EM, Barker T. Regional migratory osteoporosis: a review illustrated by five cases. Clin Radiol 2005; 60 (4) 425-438
  • 14 van de Berg BC, Lecouvet FE, Maldague B, Malghem J. Osteonecrosis and transient osteoporosis of the femoral head. In: Davies AM, Johnson K, Whitehouse RW, eds. Imaging of the Hip and Bony Pelvis: Techniques and Applications. Heidelberg, Germany: Springer; 2006: 195-216
  • 15 Grampp S, Steiner E, Imhof H. Radiological diagnosis of osteoporosis. Eur Radiol 1997; 7 (10) 11-19
  • 16 Adams JE. Osteoporosis. In: Pope TL, Bloem HL, Beltran J, Morrison WB, Wison DJ, eds. Imaging of the Musculoskeletal System. Philadelphia, PA: Saunders Elsevier; 2008: 1489-1508
  • 17 Delmas PD, van de Langerijt L, Watts NB , et al; IMPACT Study Group. Underdiagnosis of vertebral fractures is a worldwide problem: the IMPACT study. J Bone Miner Res 2005; 20 (4) 557-563
  • 18 Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet 2002; 359 (9321) 1929-1936
  • 19 Link TM. Osteoporosis imaging: state of the art and advanced imaging. Radiology 2012; 263 (1) 3-17
  • 20 Oot SG ed. Bone Health and Osteoporosis: A Report of the Surgeon-General. Rockville, MD: U.S. Department of Health and Human Services; 2004
  • 21 Sambrook P, Cooper C. Osteoporosis. Lancet 2006; 367 (9527) 2010-2018
  • 22 Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002; 359 (9319) 1761-1767
  • 23 Clinton J, Franta A, Polissar NL , et al. Proximal humeral fracture as a risk factor for subsequent hip fractures. J Bone Joint Surg Am 2009; 91 (3) 503-511
  • 24 Nielsen SP. The metacarpal index revisited: a brief overview. J Clin Densitom 2001; 4 (3) 199-207
  • 25 Rafii M, Mitnick H, Klug J, Firooznia H. Insufficiency fracture of the femoral head: MR imaging in three patients. AJR Am J Roentgenol 1997; 168 (1) 159-163
  • 26 Yamamoto T, Schneider R, Bullough PG. Insufficiency subchondral fracture of the femoral head. Am J Surg Pathol 2000; 24 (3) 464-468
  • 27 Srinivasan S, Peh WCG. Radiography in osteoporosis. In: Gugliemi G, , ed. Osteoporosis and Bone Densitometry Measurements. Berlin, Germany: Springer; 2013: 15-30
  • 28 Smyth PP, Adams JE, Whitehouse RW, Taylor CJ. Application of computer texture analysis to the Singh Index. Br J Radiol 1997; 70: 242-247
  • 29 Fayad LM, Kawamoto S, Kamel IR , et al. Distinction of long bone stress fractures from pathologic fractures on cross-sectional imaging: how successful are we?. AJR Am J Roentgenol 2005; 185 (4) 915-924
  • 30 Abe H, Nakamura M, Takahashi S, Maruoka S, Ogawa Y, Sakamoto K. Radiation-induced insufficiency fractures of the pelvis: evaluation with 99mTc-methylene diphosphonate scintigraphy. AJR Am J Roentgenol 1992; 158 (3) 599-602
  • 31 Fujii M, Abe K, Hayashi K , et al. Honda sign and variants in patients suspected of having a sacral insufficiency fracture. Clin Nucl Med 2005; 30 (3) 165-169
  • 32 Peh WCG, Khong PL, Yin Y , et al. Imaging of pelvic insufficiency fractures. Radiographics 1996; 16 (2) 335-348
  • 33 Brook AL, Mirsky DM, Bello JA. Computerized tomography guided sacroplasty: a practical treatment for sacral insufficiency fracture: case report. Spine 2005; 30 (15) E450-E454
  • 34 Cho CH, Mathis JM, Ortiz O. Sacral fractures and sacroplasty. Neuroimaging Clin N Am 2010; 20 (2) 179-186
  • 35 Frey ME, Depalma MJ, Cifu DX, Bhagia SM, Carne W, Daitch JS. Percutaneous sacroplasty for osteoporotic sacral insufficiency fractures: a prospective, multicenter, observational pilot study. Spine J 2008; 8 (2) 367-373
  • 36 Cabarrus MC, Ambekar A, Lu Y, Link TM. MRI and CT of insufficiency fractures of the pelvis and the proximal femur. AJR Am J Roentgenol 2008; 191 (4) 995-1001
  • 37 Kanaji A, Ando K, Nakagawa M, Fukaya E, Date H, Yamada H. Insufficiency fracture in the medial wall of the acetabulum after total hip arthroplasty. J Arthroplasty 2007; 22 (5) 763-767
  • 38 De Smet AA, Neff JR. Pubic and sacral insufficiency fractures: clinical course and radiologic findings. AJR Am J Roentgenol 1985; 145 (3) 601-606
  • 39 Mäenpää HM, Soini I, Lehto MU, Belt EA. Insufficiency fractures in patients with chronic inflammatory joint diseases. Clin Exp Rheumatol 2002; 20 (1) 77-79
  • 40 Greenspan SL, Myers ER, Maitland LA, Kido TH, Krasnow MB, Hayes WC. Trochanteric bone mineral density is associated with type of hip fracture in the elderly. J Bone Miner Res 1994; 9 (12) 1889-1894
  • 41 Mautalen CA, Vega EM, Einhorn TA. Are the etiologies of cervical and trochanteric hip fractures different?. Bone 1996; 18 (3, Suppl): 133S-137S
  • 42 Piscitelli P, Iolascon G, Gimigliano F , et al; SIOMMMS study group; CERSUM research group. Incidence and costs of hip fractures compared to acute myocardial infarction in the Italian population: a 4-year survey. Osteoporos Int 2007; 18 (2) 211-219
  • 43 Keene GS, Parker MJ, Pryor GA. Mortality and morbidity after hip fractures. BMJ 1993; 307 (6914) 1248-1250
  • 44 Anil G, Guglielmi G, Peh WCG. Radiology of osteoporosis. Radiol Clin North Am 2010; 48 (3) 497-518
  • 45 Dijkstra PD, Oudkerk M, Wiggers T. Prediction of pathological subtrochanteric fractures due to metastatic lesions. Arch Orthop Trauma Surg 1997; 116 (4) 221-224
  • 46 Martin-Hunyadi C, Heitz D, Kaltenbach G , et al. Spontaneous insufficiency fractures of long bones: a prospective epidemiological survey in nursing home subjects. Arch Gerontol Geriatr 2000; 31 (3) 207-214
  • 47 Shane E, Burr D, Ebeling PR , et al; American Society for Bone and Mineral Research. Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 2010; 25 (11) 2267-2294
  • 48 Franco M, Bendini JC, Blaimont A, Albano L, Cassuto E, Jaeger P. Longitudinal bone insufficiency fracture of the tibia in a renal transplant recipient. Joint Bone Spine 2003; 70 (4) 296-299
  • 49 Feydy A, Carlier R, Mutschler C, Bernard L, Leriverend V, Vallée C. A longitudinal insufficiency fracture of the tibia in association with a healed chronic osteomyelitis. Eur Radiol 2000; 10 (12) 1929-1931
  • 50 Clemetson IA, Popp A, Lippuner K, Ballmer F, Anderson SE. Postpartum osteoporosis associated with proximal tibial stress fracture. Skeletal Radiol 2004; 33 (2) 96-98
  • 51 Alonso-Bartolomé P, Martínez-Taboada VM, Blanco R, Rodriguez-Valverde V. Insufficiency fractures of the tibia and fibula. Semin Arthritis Rheum 1999; 28 (6) 413-420
  • 52 Diard F, Hauger O, Moinard M, Brunot S, Marcet B. Pseudo-cysts, lipomas, infarcts and simple cysts of the calcaneus: are there different or related lesions?. JBR-BTR 2007; 90 (5) 315-324
  • 53 Palvanen M, Kannus P, Parkkari J , et al. The injury mechanisms of osteoporotic upper extremity fractures among older adults: a controlled study of 287 consecutive patients and their 108 controls. Osteoporos Int 2000; 11 (10) 822-831
  • 54 Krestan CR, Nemec U, Nemec S. Imaging of insufficiency fractures. In: Gugliemi G, ed. Osteoporosis and Bone Densitometry Measurements. Berlin, Germany: Springer; 2013: 31-40
  • 55 Byun WM, Jang HW, Kim SW, Jang SH, Ahn SH, Ahn MW. Diffusion-weighted magnetic resonance imaging of sacral insufficiency fractures: comparison with metastases of the sacrum. Spine 2007; 32 (26) E820-E824
  • 56 Junila J, Lakovaara M, Lähde S. Diagnosis of longitudinal stress fracture of the tibia with multiplanar CT reformats: a case report. Rofo 1996; 165 (3) 303-304
  • 57 Garant M. Sacroplasty: a new treatment for sacral insufficiency fracture. J Vasc Interv Radiol 2002; 13 (12) 1265-1267
  • 58 Tsuchida T, Kosaka N, Sugimoto K, Itoh H. Sacral insufficiency fracture detected by FDG-PET/CT: report of 2 cases. Ann Nucl Med 2006; 20 (6) 445-448
  • 59 Halaç M, Mut SS, Sönmezoglu K, Ylmaz MH, Ozer H, Uslu I. Avoidance of misinterpretation of an FDG positive sacral insufficiency fracture using PET/CT scans in a patient with endometrial cancer: a case report. Clin Nucl Med 2007; 32 (10) 779-781