Abstract
Background:
The aim was to evaluate the influence of the new International Association of Diabetes and Pregnancy Study Groups (IADPSG) guidelines for screening of gestational diabetes mellitus (GDM) on GDM prevalence in a cohort from a Swiss tertiary hospital.
Methods:
This was a retrospective cohort study involving all pregnant women who were screened for GDM between 24 and 28 weeks of gestation. From 2008 until 2010 (period 1), a two-step approach with 1-h 50 g glucose challenge test (GCT) was used, followed by fasting, 1- and 2-h glucose measurements after a 75 g oral glucose tolerance test (OGTT) in case of a positive GCT. From 2010 until 2013 (period 2), all pregnant women were tested with a one-step 75 g OGTT according to new IADPSG guidelines. In both periods, women with risk factors could be screened directly with a 75 g OGTT in early pregnancy.
Results:
Overall, 647 women were eligible for the study in period 1 and 720 in period 2. The introduction of the IADPSG criteria resulted in an absolute increase of GDM prevalence of 8.5% (3.3% in period 1 to 11.8% in period 2).
Conclusions:
The adoption of the IADPSG criteria resulted in a considerable increase in GDM diagnosis in our Swiss cohort. Further studies are needed to investigate if the screening is cost effective and if treatment of our additionally diagnosed GDM mothers might improve short-term as well as long-term outcome.
Acknowledgments
We would like to thank Dorothy Huang for critical proofreading the English.
Contribution to authorship: E.A. Huhn, N. Massaro, and S Streckeisen contributed to acquisition of data. E.A. Huhn and N. Massaro are responsible for the study design and are equally contributing authors. A. Schoetzau carried out the statistical analysis and contributed to the manuscript. O. Lapaire composed the manuscript together with E.A. Huhn. G. Manegold-Brauer, I. Hoesli, S. Schulzke and B. Winzeler made important contributions and critically reviewed the content.
Disclosure of interests: The authors declare that there are no further financial or personal relationships with other people or organizations that could inappropriately influence the work reported or the conclusions, implications, or opinions stated.
Funding: This study had no financial funding.
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The authors stated that there are no conflicts of interest regarding the publication of this article.
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