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Urinary Excretion of Myo-Inositol and D-Chiro-Inositol in Early Pregnancy Is Enhanced in Gravidas With Gestational Diabetes Mellitus

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Abstract

The effects of gestational diabetes mellitus (GDM) were determined on urinary excretion of putative components of insulin signaling. Random urine samples were collected from 375 gravidas at 6 to 14 weeks’ gestation, 22 to 32 weeks’ gestation, and ∼6 weeks’ postpartum. Gestational diabetes mellitus developed in 35 women who were matched with 59 normal gravidas. Urinary concentrations of myo-inositol (MI) and D-chiro-inositol (DCI) were measured by gas chromatography/mass spectrometry and normalized to creatinine levels. Compared to postpartum values, urinary excretion of MI and DCI was increased 2.9-fold and 2-fold, respectively, in early pregnancy, and 5.5-fold and 4.5-fold, respectively, in later gestation. Gravidas with GDM had significantly greater MI and DCI excretion than controls in the first trimester but not subsequently. The results suggest that gravidas destined to develop GDM have altered synthesis, metabolism, and/or renal excretion of MI and DCI in early pregnancy.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, David Geffen School of Medicine at the University of California, BOX 951740, 27-139 CHS, Los Angeles, California, 90095-1740, USA

    Aisling Murphy, Amir Shamshirsaz & Brian Koos

  2. Department of Biomathematics, David Geffen School of Medicine at the University of California, Los Angeles, California, USA

    Daniela Markovic

  3. Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University in St Louis, St Louis, Missouri, USA

    Richard Ostlund

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  1. Aisling Murphy
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  2. Amir Shamshirsaz
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  4. Richard Ostlund
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  5. Brian Koos
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Correspondence to Aisling Murphy.

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Murphy, A., Shamshirsaz, A., Markovic, D. et al. Urinary Excretion of Myo-Inositol and D-Chiro-Inositol in Early Pregnancy Is Enhanced in Gravidas With Gestational Diabetes Mellitus. Reprod. Sci. 23, 365–371 (2016). https://doi.org/10.1177/1933719115602767

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