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Diabetes

Looking back at Look AHEAD—giving lifestyle a chance

Nature Reviews Cardiology volume 10, pages 184–186 (2013)Cite this article

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The Look AHEAD trial did not show that a lifestyle modification programme aimed at weight loss could reduce the incidence of cardiovascular disease events. We attempt to address why this trial was 'negative', and emphasize that further randomized lifestyle modification trials focusing on the effects of physical activity and exercise are needed.

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References

  1. US Department of Health and Human Services. National Institutes of Health. Weight loss does not lower heart disease risk from type 2 diabetes [online], (2012).

  2. Ryan, D. H. et al. Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Control. Clin. Trials 24, 610–628 (2003).

    Article  Google Scholar 

  3. Pi-Sunyer, X. et al. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care 30, 1374–1383 (2007).

    Article  Google Scholar 

  4. Wadden, T. A. et al. Four-year weight losses in the Look AHEAD study: factors associated with long-term success. Obesity (Silver Spring) 19, 1987–1998 (2011).

    Article  Google Scholar 

  5. Brancati, F. L. et al. Midcourse correction to a clinical trial when the event rate is underestimated: the Look AHEAD (Action for Health in Diabetes) Study. Clin. Trials 9, 113–124 (2012).

    Article  Google Scholar 

  6. Das, P. & Horton, R. Rethinking our approach to physical activity. Lancet 380, 189–190 (2012).

    Article  Google Scholar 

  7. Mozaffarian, D. Achieving cardiovascular health: a bleak outlook or tremendous potential? J. Am. Coll. Cardiol. 57, 1697–1699 (2011).

    Article  Google Scholar 

  8. Tuomilehto, J. Nonpharmacologic therapy and exercise in the prevention of type 2 diabetes. Diabetes Care 32 (Suppl. 2), S189–S193 (2009).

    Article  Google Scholar 

  9. Gregg, E. W. et al. Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA 308, 2489–2496 (2012).

    Article  CAS  Google Scholar 

  10. Unger, R. H., Clark, G. O., Scherer, P. E. & Orci, L. Lipid homeostasis, lipotoxicity and the metabolic syndrome. Biochim. Biophys. Acta 1801, 209–214 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Pavilion Marguerite-D'Youville, 4th Floor, 2725 chemin Ste-Foy, Québec, G1V 4G5, QC, Canada

    Jean-Pierre Després & Paul Poirier

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  1. Jean-Pierre Després
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  2. Paul Poirier
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Correspondence to Jean-Pierre Després.

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Competing interests

J.-P. Després has received honoraria as a speaker for Abbott Laboratories, AstraZeneca, GlaxoSmithKline, Merck, and Pfizer Canada, and as an Advisory Board member of Novartis, Theratechnologies, and Torrent Pharmaceuticals. P. Poirier declares no competing interests.

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Després, JP., Poirier, P. Looking back at Look AHEAD—giving lifestyle a chance. Nat Rev Cardiol 10, 184–186 (2013). https://doi.org/10.1038/nrcardio.2013.16

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