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The impact of vitamin D levels on glycemic control and bone mineral density in postmenopausal women with type 2 diabetes

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Abstract

Objectives

Whether glycemic control contributes to a decreased number of fractures or favorably impacts bone density in patients with type 2 diabetes mellitus (T2DM) has not been well established. Vitamin D (25 (OH) D3) deficiency appears to be related to glycemic control in patients with T2DM. The aim of this study was to determine the relationship between 25 (OH) D3 levels, glycemic control, bone mineral density (BMD), and the development of osteoporotic fractures (OPF) in postmenopausal women with T2DM.

Methods

We reviewed the charts of 110 postmenopausal women diagnosed with T2DM. Glycosylated hemoglobin A1c (HbA1c) values over the previous 5 years were recorded and an average was obtained. Based on these values, the patients were divided into three groups: optimal, suboptimal, and poor control. Bone mineral density and 25 (OH) D3 levels were also recorded.

Results

In the group of patients with poorly controlled T2DM, 25 (OH) D3 levels were not significantly lower in comparison with the optimal control group 19.29 ± 7.70 vs 17.26 ± 6.93 (p = 0.53). No statistically significant linear relationship between HbA1c and 25 (OH) D3 levels (r s = −0.17, p = 0.06) was established. The frequency of osteoporosis and osteopenia was not significantly different between groups. The group with optimal glycemic control had an increased number of OPF events (p = 0.04).

Conclusions

We do not appreciate a significant relationship between 25 (OH) D3 levels and glucose control or OPF. Therefore, more studies are needed to identify the specific effect of 25 (OH) D3 in T2DM physiopathology.

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Acknowledgments

I. Pérez-Díaz is supported by Cooperativa La Cruz Azul, S.C.L., México.

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Authors and Affiliations

  1. Medicine Department, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Vasco de Quiroga 15, Sección XVI, Tlalpan, CP. 14000, Mexico City, Mexico

    I. Perez-Diaz, R. Rivera-Moscoso & A. Flores-Rebollar

  2. Escuela Superior de Medicina, Instituto Politecnico Nacional, Plan de San Luis y Díaz Mirón s/n, Col. Casco de Santo Tomas, CP. 11340, Mexico City, Mexico

    G. Sebastian-Barajas

  3. Escuela de Medicina, Universidad Autónoma de Nayarit, Ciudad de la Cultura “Amado Nervo”, 63155, Nayarit, Mexico

    Z. G. Hernandez-Flores

  4. Tecnológico de Monterrey, Escuela de Medicina, CCM. Calle Del Puente 222, CP. 14380, Mexico City, Mexico

    H. K. Osorio-Landa

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  1. I. Perez-Diaz
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  2. G. Sebastian-Barajas
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Correspondence to I. Perez-Diaz.

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Conflict of interest

The authors do not have any conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Ethical approval

The Institutional Review Board approved the study. All procedures performed in human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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For this type of study informed consent is not required.

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This research did not receive any specific grant from any funding agency in the public, commercial, or not-for-profit sector.

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Perez-Diaz, I., Sebastian-Barajas, G., Hernandez-Flores, Z.G. et al. The impact of vitamin D levels on glycemic control and bone mineral density in postmenopausal women with type 2 diabetes. J Endocrinol Invest 38, 1365–1372 (2015). https://doi.org/10.1007/s40618-015-0394-4

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  • DOI: https://doi.org/10.1007/s40618-015-0394-4

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