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Interrelations among the adipocytokines leptin and adiponectin, oxidative stress and aseptic inflammation markers in pre- and early-pubertal normal-weight and obese boys

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Abstract

Purpose

Presumed interrelationships among deleterious aspects of adipose tissue metabolism, inflammation, and cellular oxidative stress could be influenced by pubertal hormonal changes. They were investigated in pre- and early pubertal normal-weight and obese boys before and after an exercise bout employed as an energy demanding stimulator.

Methods

Cross-sectional study. Seventy-six healthy pre- (mean ± SD, 10.6 ± 0.2 years old, 28 normal-weight, and 11 obese) and early-(11.4 ± 0.2 years old, 25 normal-weight, and 12 obese) pubertal boys, were blood-sampled before and after a bout of exercise at 70% VO2 max. Leptin, adiponectin, markers of inflammation (high-sensitivity C-reactive protein, high sensitivity IL-6), pro- (thiobarbitouric acid reactive substances, protein carbonyls) and anti- (glutathione, oxidized glutathione, glutathione peroxidase, catalase, total antioxidant capacity) oxidation were measured.

Results

Baseline and post-exercise adiponectin was greater and leptin and high-sensitivity C-reactive protein were lower in normal-weight than in obese pre- and early pubertal boys, while high sensitivity IL-6 was greater in obese than in normal-weight pre-pubertal boys. In pre-pubertal obese boys: at baseline, high-sensitivity C-reactive protein correlated negatively with catalase; high sensitivity IL-6 correlated positively with protein carbonyls; Δ (difference during exercise) adiponectin correlated positively with Δcatalase. In all boys: at baseline, high sensitivity IL-6 correlated positively with leptin and was the best negative and the second best positive predictor for post-exercise glutathione/oxidized glutathione and protein carbonyls, respectively; leptin was the best negative predictor for post-exercise glutathione; waist to height ratio was the best positive predictor for post-exercise thiobarbitouric acid reactive substances; body mass index z-score and adiponectin were, respectively, the best positive predictor for post-exercise protein carbonyls and catalase.

Conclusions

In all subjects, leptin and adiponectin predict negatively and positively anti-oxidation, respectively, while high sensitivity IL-6 predicts positively and negatively pro- and anti-oxidation, respectively. High-sensitivity C-reactive protein is increased and negatively associated with anti-oxidation in pre-pubertal obese boys, suggesting that childhood obesity is associated with aseptic inflammation and oxidative stress.

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Authors and Affiliations

  1. Endocrine Unit, “Aretaieion” Hospital, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece

    George Paltoglou, George Valsamakis & George Mastorakos

  2. First Department of Pediatrics, “Aghia Sophia” Children’s Hospital, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece

    George Paltoglou, Christina Kanaka-Gantenbein & George P. Chrousos

  3. Department of Physical Education and Sports Sciences, Democritus University of Thrace, Komotini, Greece

    Maria Schoina, Alexandra Avloniti & Athanasios Chatzinikolaou

  4. Second Department of Obstetrics and Gynecology, “Aretaieion” Hospital, National and Kapodistrian University of Athens - Faculty of Medicine, Athens, Greece

    Nicolaos Salakos

  5. Department of Clinical Biochemistry, “Aghia Sophia” Children’s Hospital, Athens, Greece

    Alexandra Margeli, Chrysanthi Skevaki & Ioannis Papassotiriou

  6. Pediatric Endocrinology Unit, Third Department of Pediatrics, “Hippokrateion” General Hospital of Thessaloniki, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece

    Maria Papagianni

  7. Department of Physical Education and Sports Sciences, University of Thessaly, Trikala, Greece

    Ioannis G. Fatouros

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  1. George Paltoglou
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Paltoglou, G., Schoina, M., Valsamakis, G. et al. Interrelations among the adipocytokines leptin and adiponectin, oxidative stress and aseptic inflammation markers in pre- and early-pubertal normal-weight and obese boys. Endocrine 55, 925–933 (2017). https://doi.org/10.1007/s12020-017-1227-3

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