Abstract
The objective of this study is to investigate bone metabolism, density, and quality in patients with diabetes type 2 using DEXA and spinal deformity index (SDI), a surrogate index of bone quality. Fifty-six patients with type 2 diabetes were studied; exclusion criteria were diseases and medications that affect bone and mineral metabolism. Mean age was 65 ± 7 years. Mean diabetes duration was 10 ± 7 years and mean HbA1C was 6.6 ± 0.5 %. BMI was 30 ± 4. Fifty-six sex, age, and BMI matched served as controls. All subjects underwent a clinical and biochemical examination. Spinal and femoral neck BMD were measured by DEXA, and a spine radiography was performed to assess vertebral fractures and to calculate SDI. Mean serum 25-OH vitamin D levels were 19.6 ± 3.7 ng/ml in patients and 30 ± 14 ng/ml in controls (p < 0.01). PTH serum levels were 47.9 ± 40 pg/ml in patients versus 37 ± 5.3 pg/ml in controls (p < 0.01). At lumbar spine there was a significant difference between patients and controls only for T-score (p = <0.01), while at femoral neck there was a difference in BMD (p < 0.01) and in T-score (p < 0.01). Radiological vertebral fractures were found in 46 % of patients and 17 % of controls (p < 0.05). SDI was higher in patients than in controls (p < 0.05). The percentage of fractures with T-score BMD greater than −2.5 was 69 % in patients and 10 % in controls (p < 0.05). As a conclusion, BMD was similar in patients and in controls, while SDI value was higher in patients; therefore, SDI was more specific than BMD for the diagnosis of osteoporosis due to metabolic diseases.
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Acknowledgments
CDS researched and analyzed data and drafted the manuscript. AF, NT, and MA performed the clinical investigation. LV, PC, and SS gathered the data. CA critically revised the manuscript. MR contributed to the study design, to performing statistics, and drafting manuscript. All Authors read and approved the final manuscript.
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The authors declare that they have no competing interests, and no potential conflicts of interest relevant to this article were reported.
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Di Somma, C., Rubino, M., Faggiano, A. et al. Spinal deformity index in patients with type 2 diabetes. Endocrine 43, 651–658 (2013). https://doi.org/10.1007/s12020-012-9848-z
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DOI: https://doi.org/10.1007/s12020-012-9848-z