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Bone Microarchitecture in Type 1 Diabetes: It Is Complicated

  • Bone and Diabetes (A Schwartz and P Vestergaard, Section Editors)
  • Published:
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Abstract

Patients with type 1 diabetes (T1DM) experience a disproportionate number of fractures for their bone mineral density (BMD). Differences in bone microarchitecture from those without the disease are thought to be responsible. However, the literature is inconclusive. New studies of the microarchitecture using three-dimensional imaging have the advantage of providing in vivo estimates of “bone quality,” rather than examining areal BMD alone. There are drawbacks in that most studies have been done on those with less than a 30-year duration of T1DM, and the techniques used to measure vary as do the sites assessed. In addition to the rise in these imaging techniques, very recent literature presents evidence of an intimate relationship between skeletal health and vascular complications in T1DM. The following review provides an overview of the available studies of the bone microarchitecture in T1DM with a discussion of the burgeoning field of complications and skeletal health.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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    Authors and Affiliations

    1. Research Division, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA, 02215, USA

      Hillary A. Keenan & Ernesto Maddaloni

    2. Department of Medicine, Unit of Endocrinology and Diabetes, University Campus Bio-Medico of Rome, Rome, Italy

      Ernesto Maddaloni

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    1. Hillary A. Keenan
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    Correspondence to Hillary A. Keenan.

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    No animal or human studies were done for this manuscript. The authors were not authors on any of the papers referenced in this review.

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    This article is part of the Topical Collection on Bone and Diabetes

    Hillary A. Keenan and Ernesto Maddaloni contributed equally to this work.

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    Keenan, H.A., Maddaloni, E. Bone Microarchitecture in Type 1 Diabetes: It Is Complicated. Curr Osteoporos Rep 14, 351–358 (2016). https://doi.org/10.1007/s11914-016-0338-8

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