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Thiazide and Thiazide-like Diuretics: An Opportunity to Reduce Blood Pressure in Patients with Advanced Kidney Disease

  • Antihypertensive Therapy: Renal Injury (MR Weir and GL Bakris, Section Editors)
  • Published:
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Abstract

Thiazide and thiazide-like diuretics have been widely used as blood pressure-lowering agents for more than 5 decades. However, their use in patients with advanced chronic kidney disease has been limited and often discouraged. The exact mechanism of how thiazide and thiazide-like diuretics lower blood pressures is still in question. Emerging evidence suggests that thiazides and thiazide-like diuretics are effective as blood pressure-lowering drugs in patients with advanced chronic kidney disease. Review of the literature suggests that physicians should not discard thiazide and thiazide-like diuretics as options for blood pressure management in patients with chronic advanced kidney disease.

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Acknowledgments

We thank Tia A. Paul, University of Maryland School of Medicine, Baltimore, MD, USA, for expert secretarial support.

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No potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA

    Feras Karadsheh & Matthew R. Weir

  2. Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, 22 S. Greene St., Room N3W142, Baltimore, MD, 21201, USA

    Matthew R. Weir

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  1. Feras Karadsheh
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Correspondence to Matthew R. Weir.

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Karadsheh, F., Weir, M.R. Thiazide and Thiazide-like Diuretics: An Opportunity to Reduce Blood Pressure in Patients with Advanced Kidney Disease. Curr Hypertens Rep 14, 416–420 (2012). https://doi.org/10.1007/s11906-012-0293-4

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  • DOI: https://doi.org/10.1007/s11906-012-0293-4

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