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Pharmacotherapy of Obesity: Clinical Trials to Clinical Practice

  • Obesity (J McCaffery, Section Editor)
  • Published:
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Abstract

Purpose of Review

This review provides an overview of the current state of drug therapy for obesity, with a focus on four new drug therapies—lorcaserin, phentermine/topiramate, naltrexone/bupropion, and liraglutide 3.0 mg—which have been approved by the US Food and Drug Administration (FDA) for long-term management of obesity since 2012. Topics discussed in this paper include rationale for pharmacotherapy, history of antiobesity drugs, and efficacy and safety data from randomized controlled trials with implications for clinical practice.

Recent Findings

Weight loss achieved by currently approved drugs ranges from approximately 3 to 9%, above and beyond weight loss with lifestyle counseling alone, after a year. Response and attrition rates in clinical trials indicate that the benefits of pharmacotherapy range from substantial for some patients, modest for others, and no benefits for others still.

Summary

Decisions regarding selection of a suitable drug from the available pharmacotherapy options and duration of treatment should be based on the expected and observed benefit-to-risk balance and tailored to the needs of each individual patient using the principles of shared decision-making.

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References

Papers of particular interest, published recently, have been highlighted as: •Of importance •• Of major importance

  1. Haslam DW, James WPT. Obesity. Lancet. 2005;366:1197–209.

    Article  PubMed  Google Scholar 

  2. •• Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults. Circulation. 2014;129(suppl 2):S102–38. Recently published guideline for the management of obesity co-developed by the American College of Cardiology, American Heart Association, and The Obesity Society

    Article  PubMed  Google Scholar 

  3. National Heart. Lung, and Blood Institute, National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Bethesda, MD. NIH Publication No. 98–4083, National Institutes of Health, September 1998.

  4. Moyer VA. Screening for and management of obesity in adults: U.S. preventive services task force recommendation. Ann Intern Med. 2012;157:373–8.

    PubMed  Google Scholar 

  5. Kramer FM, Jeffery RW, Forster JL, Snell MK. Long-term follow-up of behavioral treatment for obesity: patterns of weight regain among men and women. Int J Obes. 1989;13:123–36.

    CAS  PubMed  Google Scholar 

  6. Douketis JD, Macie C, Thabane L, Williamson DF. Systematic review of long-term weight loss studies in obese adults: clinical significance and applicability to clinical practice. Int J Obes. 2005;29:1153–67.

    Article  CAS  Google Scholar 

  7. Diabetes Prevention Program (DPP) Research Group. The diabetes prevention program (DPP): description of lifestyle intervention. Diabetes Care. 2002;25:2165–71.

    Article  Google Scholar 

  8. The Look AHEAD Research Group. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care. 2007;30:1374–83.

    Article  Google Scholar 

  9. Ryan DH, Kushner R. The state of obesity and obesity research. JAMA. 2010;304:1835–6.

    Article  CAS  PubMed  Google Scholar 

  10. The Look AHEAD Research Group. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes. N Engl J Med. 2013;369:145–54.

    Article  PubMed Central  Google Scholar 

  11. Carlsson LMS, Peltonen M, Ahlin S, et al. Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects. N Engl J Med. 2012;367:695–701.

    Article  CAS  PubMed  Google Scholar 

  12. Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357:753–61.

    Article  CAS  PubMed  Google Scholar 

  13. Dorman RB, Miller CJ, Leslie DB, et al. Risk for hospital readmission following bariatric surgery. PLoS One. 2012;7:e32506.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Almahmeed T, Gonzalez R, Nelson LG, et al. Morbidity of anastomotic leaks in patients undergoing Roux-en-Y gastric bypass. Arch Surg. 2007;142:954–7.

    Article  PubMed  Google Scholar 

  15. Hamdan K, Somers S, Chand M. Management of late postoperative complications of bariatric surgery. Br J Surg. 2011;98:1345–55.

    Article  CAS  PubMed  Google Scholar 

  16. Anderson JW, Greenway FL, Fujioka K, et al. Bupropion SR enhances weight loss: a 48-week double-blind, placebo-controlled trial. Obes Res. 2002;10:633–41.

    Article  CAS  PubMed  Google Scholar 

  17. Wadden TA, Berkowitz RI, Womble LG, et al. Randomized trial of lifestyle modification and pharmacotherapy for obesity. N Engl J Med. 2005;353:2111–20.

    Article  CAS  PubMed  Google Scholar 

  18. Wadden TA, Foreyt JP, Foster GD, et al. Weight loss with naltrexone SR/bupropion SR combination therapy as an adjunct to behavior modification: the COR-BMOD trial. Obesity. 2011;19:110–20.

    Article  CAS  PubMed  Google Scholar 

  19. Richelsen B, Tonstad S, Rössner S, et al. Effect of orlistat on weight regain and cardiovascular risk factors following a very-low-energy diet in abdominally obese patients: a 3-year, randomized, placebo-controlled trial. Diabetes Care. 2007;30:27–32.

    Article  CAS  PubMed  Google Scholar 

  20. Wadden TA, Hollander P, Klein S, et al. Weight maintenance and additional weight loss with liraglutide after low-calorie-diet induced weight loss: the SCALE maintenance randomized study. Int J Obes. 2013;37:1443–51.

    Article  CAS  Google Scholar 

  21. Haddock CK, Poston WSC, Dill PL, et al. Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials. Int J Obes. 2002;26:262–73.

    Article  CAS  Google Scholar 

  22. Stafford RS, Radley DC. National trends in antiobesity medication use. Arch Intern Med. 2003;163:1046–50.

    Article  PubMed  Google Scholar 

  23. Hampp C, Kang EM, Borders-Hemphill V. Use of prescription antiobesity drugs in the United States. Pharmacotherapy. 2013;33:1299–307.

    Article  PubMed  PubMed Central  Google Scholar 

  24. James WPT, Caterson ID, Coutinho W, et al. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med. 2010;363:905–15.

    Article  CAS  PubMed  Google Scholar 

  25. Gadde KM, Allison DB. Cannabinoid-1 receptor antagonist, rimonabant, for management of obesity and related risks. Circulation. 2006;114:974–84.

    Article  CAS  PubMed  Google Scholar 

  26. Leblanc ES, O’Connor E, Whitlock EP, et al. Effectiveness of primary care-relevant treatments for obesity in adults: a systematic evidence review for the U.S. preventive services task force. Ann Intern Med. 2011;155:434–47.

    Article  PubMed  Google Scholar 

  27. Yanovski SN, Yanovski JA. Long-term drug treatment of obesity: a systematic and clinical review. JAMA. 2014;311:74–86.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Rucker D, Padwal R, Li SK, et al. Long term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ. 2007;335:1194–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Khera R, Murad MH, Chandar A, et al. Association of pharmacological treatments for obesity with weight loss and adverse events. A systematic review and meta-analysis. JAMA. 2016;315:2424–34.

    Article  CAS  PubMed  Google Scholar 

  30. Food and Drug Administration. Orlistat nonprescription briefing document: NDA 21–887. Endocrine and metabolic drugs advisory committee meeting, January 23, 2006. Available at: http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4201B1_02_03-FDA-Clinical-Review.pdf . Accessed Jan 24, 2017.

  31. Padwal R, Kezouh A, Levine M, Etminan M. Long-term persistence with orlistat and sibutramine in a population-based cohort. Int J Obes. 2007;31:1567–70.

    Article  CAS  Google Scholar 

  32. Rothman RB, Baumann MH, Dersch CM, et al. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse. 2001;39:32–41.

    Article  CAS  PubMed  Google Scholar 

  33. Alexander M, Rothman RB, Baumann MH, et al. Noradrenergic and dopaminergic effects of (+)-amphetamine-like stimulants in the baboon Papio Anubis. Synapse. 2005;56:94–9.

    Article  CAS  PubMed  Google Scholar 

  34. Kang JG, Park C-Y, Kang JH, et al. Randomized controlled trial to investigate the effects of a newly developed formulation of phentermine diffuse-controlled release for obesity. Diabetes Obes Metab. 2010;12:876–80.

    Article  CAS  PubMed  Google Scholar 

  35. Kim KK, Cho H-J, Kang H-C, et al. Effects of weight reduction and safety of short-term phentermine administration in Korean obese people. Yonsei Med J. 2006;47:614–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Silverstone T. Appetite suppressants: a review. Drugs. 1992;43:820–36.

    Article  CAS  PubMed  Google Scholar 

  37. Prescribing information for Suprenza™ (phentermine hydrochloride) orally disintegrating tablet. Akrimax Pharmaceuticals, Jan 2015.

  38. Jick H, Vasilakis C, Weinrauch LA, et al. A population-based study of appetite-suppressant drugs and the risk of cardiac-valve regurgitation. N Engl J Med. 1998;339:719–24.

    Article  CAS  PubMed  Google Scholar 

  39. Rothman RB, Baumann MH, Savage JE, et al. Evidence for possible involvement of 5-HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000;102:2836–41.

    Article  CAS  PubMed  Google Scholar 

  40. Rosenfeld WE. Topiramate: a review of preclinical, pharmacokinetic, and clinical data. Clin Ther. 1997;19:1294–308.

    Article  CAS  PubMed  Google Scholar 

  41. Ben-Menachem E, Sander JW, Johanson EH, et al. Predictors of weight loss in adults with topiramate treated epilepsy. Obes Res. 2003;11:556–62.

    Article  CAS  PubMed  Google Scholar 

  42. Verrotti A, Scaparrotta A, Agostinelli S, et al. Topiramate-induced weight loss: a review. Epilepsy Res. 2011;95:189–99.

    Article  CAS  PubMed  Google Scholar 

  43. Bray GA, Hollander P, Klein S, et al. A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity. Obes Res. 2003;6:722–33.

    Article  Google Scholar 

  44. Wilding J, Van Gaal L, Rissanen A, et al. A randomized double-blind placebo-controlled study of the long-term efficacy and safety of topiramate in the treatment of obese subjects. Int J Obes. 2004;28:1399–410.

    Article  CAS  Google Scholar 

  45. Astrup A, Caterson I, Zelissen P, et al. Topiramate: long-term maintenance of weight loss induced by a low-calorie diet in obese subjects. Obes Res. 2004;12:1658–69.

    Article  CAS  PubMed  Google Scholar 

  46. Tonstad S, Tykarski A, Weissgarten J, et al. Efficacy and safety of topiramate in the treatment of obese subjects with essential hypertension. Am J Cardiol. 2005;96:243–51.

    Article  CAS  PubMed  Google Scholar 

  47. Stenlöf K, Rössner S, Vercruysse F, et al. Topiramate in the treatment of obese subjects with drug-naive type 2 diabetes. Diabetes Obes Metab. 2007;9:360–8.

    Article  PubMed  Google Scholar 

  48. Eliasson B, Gudbjörnsdottir S, Cederholm J, et al. Weight loss and metabolic effects of topiramate in overweight and obese type 2 diabetic patients: randomized double-blind placebo-controlled trial. Int J Obes. 2007;31:1140–7.

    Article  CAS  Google Scholar 

  49. Toplak H, Hamann A, Moore R, et al. Efficacy and safety of topiramate in combination with metformin in the treatment of obese subjects with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Int J Obes. 2007;31:138–46.

    Article  CAS  Google Scholar 

  50. Rosenstock J, Hollander P, Gadde KM, et al. A randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of topiramate controlled release in the treatment of obese type 2 diabetic patients. Diabetes Care. 2007;30:1480–6.

    Article  CAS  PubMed  Google Scholar 

  51. Kramer CK, Leitao CB, Pinto LC, et al. Efficacy and safety of topiramate on weight loss: a meta-analysis of randomized controlled trials. Obes Rev. 2011;12:e338–47.

    Article  CAS  PubMed  Google Scholar 

  52. Gadde KM, Yonish GM, Foust MS, et al. A 24-week randomized controlled trial of VI-0521, a combination weight loss therapy, in obese adults. Obes Res. 2006;14:A17. abstract 406-P

    Google Scholar 

  53. Aronne LJ, Wadden TA, Peterson C, et al. Evaluation of phentermine and topiramate versus phentermine/topiramate extended-release in obese adults. Obesity. 2013;21:2163–71.

    Article  CAS  PubMed  Google Scholar 

  54. Allison DB, Gadde KM, Garvey WT, et al. Controlled-release phentermine/topiramate in severely obese adults: a randomized controlled trial (EQUIP). Obesity. 2012;20:330–42.

    Article  CAS  PubMed  Google Scholar 

  55. • Gadde KM, Allison DB, Ryan DH, et al. Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial. Lancet. 2011;377:1341–52. Largest and most definitive phase 3 RCT of phentermine/topiramate

    Article  CAS  PubMed  Google Scholar 

  56. Garvey WT, Ran DH, Look M, et al. Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study. Am J Clin Nutr. 2012;95:297–308.

    Article  CAS  PubMed  Google Scholar 

  57. Food and Drug Administration. Advisory committee meeting for phentermine/topiramate (Qnexa), July 15, 2010. Division of Metabolism and Endocrinology Products (DMEP), Office of Drug Evaluation II, Center for Drug Evaluation and Research, Silver Spring, MD. Available at: http://www.fda.gov/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/ucm218819.htm. Accessed Jan 23, 2017.

  58. Food and Drug Administration. FDA news release: FDA approves weight-management drug Qsymia. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm312468.htm. Accessed Jan 23, 2017.

  59. Hernández-Díaz S, Smith CR, Shen A, et al. Comparative safety of antiepileptic drugs during pregnancy. Neurology. 2012;78:1692–9.

    Article  PubMed  Google Scholar 

  60. Margulis AV, Mitchell AA, Gilboa SM, et al. Use of topiramate in pregnancy and risk of oral clefts. Am J Obstet Gynecol. 2012;207:405e1–7.

    Article  Google Scholar 

  61. Vivus, Inc. NDA 22580. Qsymia (phentermine and topiramate extended-release) Capsules: risk evaluation and mitigation strategy (REMS). Initial REMS approval, 07/2012; most recent modification, 09/2014. Available at: http://www.fda.gov/downloads/Drugs/DrugSafety/postmarketdrugsafetyinformationforpatientsandproviders/UCM312598.pdf. Accessed Jan 23, 2017.

  62. • Gadde KM, Parker CB, Maner LG, et al. Bupropion for weight loss: an investigation of efficacy and tolerability in overweight and obese women. Obes Res. 2001;9:544–51. First RCT of bupropion for weight loss in obese adults

    Article  CAS  PubMed  Google Scholar 

  63. Jain AK, Kaplan RA, Gadde KM, et al. Bupropion SR vs. placebo for weight loss in obese patients with depressive symptoms. Obes Res. 2002;10:1049–56.

    Article  CAS  PubMed  Google Scholar 

  64. Atkinson RL, Berke LK, Drake CR, et al. Effects of long-term therapy with naltrexone on body weight in obesity. Clin Pharmacol Ther. 1985;38:419–22.

    Article  CAS  PubMed  Google Scholar 

  65. Malcolm R, O’Neil PM, Sexauer JD, et al. A controlled trial of naltrexone in obese humans. Int J Obes. 1985;9:347–53.

    CAS  PubMed  Google Scholar 

  66. United States Patent and Trademark Office. United States patent 7,462,626, December 9, 2008. Compositions for affecting weight loss. Available at: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=14&f=G&l=50&co1=AND&d=PTXT&s1=7462626&OS=7462626&RS=7462626. Accessed Jan 23, 2017.

  67. Orexigen Therapeutics. Contrave (Naltrexone SR/Bupropion SR combination), NDA 200063. Advisory committee briefing document. Endocrinologic and Metabolic Drugs Advisory Committee Meeting, December 7, 2010. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM235672.pdf. Accessed Jan 23, 2017.

  68. Greenway FL, Whitehouse MJ, Guttadauria M, et al. Rational design of a combination medication for the treatment of obesity. Obesity. 2009;17:30–9.

    Article  CAS  PubMed  Google Scholar 

  69. Greenway FL, Dunayevich E, Tollefson G, et al. Comparison of combined bupropion and naltrexone therapy for obesity with monotherapy and placebo. J Endocrinol Metab. 2009;94:4898–906.

    Article  CAS  Google Scholar 

  70. Food and Drug Administration. FDA briefing document, NDA 200063. Advisory committee meeting for naltrexone/bupropion (Contrave), Endocrinologic & Metabolic Drugs Advisory Committee, 7 Dec 2010. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM235671.pdf. Accessed Jan 23, 2017.

  71. • Nissen SE, Wolski KE, Prcela L, et al. Effect of naltrexone-bupropion on major adverse cardiovascular events in overweight and obese patients with cardiovascular risk factors: a randomized clinical trial. JAMA. 2016;315:990–1004. Largest and longest study of naltrexone/bupropion designed to investigate the risk of major adverse cardiovascular events

    Article  CAS  PubMed  Google Scholar 

  72. Thomsen WJ, Grottick AJ, Menzaghi F, et al. Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization. J Pharmacol Exp Ther. 2008;325:577–87.

    Article  CAS  PubMed  Google Scholar 

  73. • Smith DR, Weissman NJ, Anderson CM, et al. Behavior modification and lorcaserin for overweight and obesity management (BLOOM) study group: multicenter, placebo-controlled trial of lorcaserin for weight management. N Engl J Med. 2010;363:245–56. Largest and longest published RCT of lorcaserin

    Article  CAS  PubMed  Google Scholar 

  74. Fidler MC, Sanchez M, Raether B, et al. A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial. J Clin Endocrinol Metab. 2011;96:3067–77.

    Article  CAS  PubMed  Google Scholar 

  75. O’Neil PM, Smith SR, Weissman NJ, et al. Randomized placebo-controlled clinical trial of lorcaserin for weight loss in type 2 diabetes mellitus: the BLOOM-DM study. Obesity. 2012;20:1426–36.

    Article  PubMed  Google Scholar 

  76. Food and Drug Administration. FDA briefing document, NDA 22529. Advisory committee meeting for lorcaserin. Endocrinologic & Metabolic Drugs Advisory Committee, 16 Sep 2010. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM225631.pdf. Accessed Jan 23, 2017.

  77. Colman E, Golden J, Roberts M, et al. The FDA’s assessment of two drugs for chronic weight management. N Engl J Med. 2012;367:1577–8.

    Article  CAS  PubMed  Google Scholar 

  78. Eisai, Inc. A study to evaluate the effect of long-term treatment with BELVIQ (Lorcaserin HCl) on the incidence of major adverse cardiovascular events and conversion to type 2 diabetes mellitus in obese and overweight subjects with cardiovascular disease or multiple cardiovascular risk factors (CAMELLIA-TIMI). ClinicalTrials.gov Identifier NCT 02019264. Available at: https://clinicaltrials.gov/ct2/show/NCT02019264?term=lorcaserin+cardiovascular&rank=1. Accessed Jan 23, 2017.

  79. Prescribing information for Belviq® (lorcaserin HCl) for oral use, CIV. Arena Pharmaceuticals, Zofingen, Switzerland, and Eisai, Inc., Woodcliff Lake, NJ, Dec 2015.

  80. Flint A, Raben A, Ak E, et al. The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, and energy and substrate metabolism in obesity. Int J Obes. 2001;25:781–92.

    Article  CAS  Google Scholar 

  81. Sisley S, Gutierrez-Aguilar R, Scott M, et al. Neuronal GLP1R mediates liraglutide’s anorectic but not glucose-lowering effect. J Clin Invest. 2014;124:2456–63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Astrup A, Rössner S, Van Gaal L, et al. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet. 2009;374:1606–16.

    Article  CAS  PubMed  Google Scholar 

  83. Food and Drug Administration. FDA briefing document, NDA 206321, liraglutide injection, 3 mg. Endocrinologic and Metabolic Drugs Advisory Committee meeting, 11 September 2014. Available at: http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM413317.pdf. Accessed Jan 23, 2017.

  84. • Pi-Sunyer X, Astrup A, Fujioka K, et al. A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N Engl J Med. 2015;373:11–22. Largest phase 3 RCT of liraglutide

    Article  PubMed  Google Scholar 

  85. le Roux CW, Astrup A, Fujioka K, et al. Three years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial. Lancet. 2017. doi:10.1016/S0140-6736(17)30069-7.

  86. Davies MJ, Bergenstal R, Bode B, et al. Efficacy of liraglutide for weight loss among patients with type 2 diabetes: the SCALE diabetes randomized clinical trial. JAMA. 2015;314:687–99.

    Article  CAS  PubMed  Google Scholar 

  87. Blackman A, Foster GD, Zammit G, et al. Effect of liraglutide 3.0 mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE sleep apnea randomized clinical trial. Int J Obes. 2016;40:1310–9.

    Article  CAS  Google Scholar 

  88. Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375:311–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA, 70810, USA

    Kishore M. Gadde

  2. Department of Internal Medicine, Oregon Health & Science University, Portland, OR, 97239, USA

    Y. Pritham Raj

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Correspondence to Kishore M. Gadde.

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Conflict of Interest

Dr. Gadde reports grants from Bristol Myers Squibb, Eisai, and NIDDK in the past 3 years. In addition, Dr. Gadde has been awarded several patents related to obesity and body weight, in the name of his previous employer, Duke University, which licensed the patents to Orexigen Therapeutics. Dr. Gadde has not owned stocks in Orexigen in the past 3 years. He has not received and does not stand to receive any royalties related to his patents. The inventions disclosed in Dr. Gadde’s patents have not been discussed in this manuscript.

Dr. Raj has no disclosures.

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This review article does not contain any studies with human subjects or animals performed by any of the authors.

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This article is part of the Topical Collection on Obesity

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Gadde, K.M., Pritham Raj, Y. Pharmacotherapy of Obesity: Clinical Trials to Clinical Practice. Curr Diab Rep 17, 34 (2017). https://doi.org/10.1007/s11892-017-0859-2

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