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Management of Severe Insulin Resistance in Patients with Type 1 Diabetes

  • Treatment of Type 1 Diabetes (M Pietropaolo, Section Editor)
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Abstract

Managing severe insulin resistance (IR) in patients with type 1 diabetes (T1DM) can be challenging for both clinicians and patients. As average weight for patients with T1DM has increased in recent decades, IR in this population has become more widespread. Currently, almost 50 % of patients with T1DM are overweight or obese. While intensive insulin therapy is associated with reduction in complications, aggressive treatment can lead to weight gain. With increasing weight, insulin can become less effective to control glycemia, resulting in higher insulin doses and hence more weight gain. Novel strategies to break this vicious cycle are needed. This review will investigate current research on insulin formulations, lifestyle modification, adjunct therapies, and surgery that may help better manage patients with T1DM and IR.

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Rebecca Schechter declares that she has no conflict of interest.

Sirimon Reutrakul reports personal fees from Sanofi Aventis and grants from Merck.

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  1. Division of Endocrinology and Metabolism, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama VI Rd, Ratchathewi, Bangkok, 10400, Thailand

    Sirimon Reutrakul

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  1. Rebecca Schechter
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Correspondence to Sirimon Reutrakul.

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This article is part of the Topical Collection on Treatment of Type 1 Diabetes

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Schechter, R., Reutrakul, S. Management of Severe Insulin Resistance in Patients with Type 1 Diabetes. Curr Diab Rep 15, 77 (2015). https://doi.org/10.1007/s11892-015-0641-2

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