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Metabolic and Glycemic Sequelae of Sleep Disturbances in Children and Adults

  • Pediatric Type 2 Diabetes (PS Zeitler, Section Editor)
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Abstract

The prevalence of obesity in adults and children has increased greatly in the past three decades, as have metabolic sequelae, such as insulin resistance and type 2 diabetes mellitus (T2DM). Sleep disturbances are increasingly recognized as contributors to this widespread epidemic in adults, and data are emerging in children as well. The categories of sleep disturbances that contribute to obesity and its glycemic co-morbidities include the following: (1) alterations of sleep duration, chronic sleep restriction and excessive sleep; (2) alterations in sleep architecture; (3) sleep fragmentation; (4) circadian rhythm disorders and disruption (i.e., shift work); and (5) obstructive sleep apnea. This article reviews current evidence supporting the contributions that these sleep disorders play in the development of obesity, insulin resistance, and T2DM as well as possibly influences on glycemic control in type 1 diabetes, with a special focus on data in pediatric populations.

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Conflict of Interest

Dorit Koren declares that she has no conflict of interest.

Katie L. O’Sullivan declares that she has no conflict of interest.

Babak Mokhlesi is supported, in part, by NIH grant R01 HL-119161, and he has also received compensation from Philips/Respironics for service as a consultant, and is currently participating in a study sponsored by Philips/Respironics.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Section of Endocrinology, Diabetes and Metabolism, Department of Pediatrics and Medicine, The University of Chicago, Chicago, IL, 60614, USA

    Dorit Koren & Katie L. O’Sullivan

  2. Sleep, Metabolism and Health Center, Department of Medicine, The University of Chicago, Chicago, IL, 60614, USA

    Dorit Koren & Babak Mokhlesi

  3. Section of Pulmonary and Critical Care, Department of Medicine, The University of Chicago, Chicago, IL, 60614, USA

    Babak Mokhlesi

Authors
  1. Dorit Koren
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  2. Katie L. O’Sullivan
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  3. Babak Mokhlesi
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Corresponding author

Correspondence to Dorit Koren.

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Dr. Babak Mokhlesi is the senior author on this manuscript.

This article is part of the Topical Collection on Pediatric Type 2 Diabetes

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Koren, D., O’Sullivan, K.L. & Mokhlesi, B. Metabolic and Glycemic Sequelae of Sleep Disturbances in Children and Adults. Curr Diab Rep 15, 562 (2015). https://doi.org/10.1007/s11892-014-0562-5

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  • DOI: https://doi.org/10.1007/s11892-014-0562-5

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