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Look Inside Look AHEAD: Why the Glass Is More than Half-Full

  • Macrovascular Complications in Diabetes (L Perreault, Section Editor)
  • Published:
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Abstract

Look AHEAD is the only long-term study in a large cohort of subjects with type 2 diabetes that assessed the effect of intensive lifestyle, predominantly diet and exercise, on a number of outcomes. While Look AHEAD was not able to detect a significant effect of intensive lifestyle modification on cardiovascular outcomes, it clearly demonstrated numerous beneficial and sustained effects on health outcomes that are relevant to this population. Without the exceptional retention of study participants, it would have been difficult to detect these benefits. Our review provides a perspective on aspects related to exercise, diet, and weight loss in relation to cardiovascular outcomes and potential future research.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Acknowledgments

The authors would like to thank Ms. Tara Bea for her editorial and administrative work.

Compliance with Ethics Guidelines

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Conflict of Interest

Helmut Steinberg, Crystal Jacovino, and Abbas E. Kitabchi declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Division of Endocrinology, Diabetes, and Metabolism, University of Tennessee Health Science Center, 956 Court Ave, A202, Memphis, TN, 38163, USA

    Helmut Steinberg, Crystal Jacovino & Abbas E. Kitabchi

Authors
  1. Helmut Steinberg
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  2. Crystal Jacovino
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  3. Abbas E. Kitabchi
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Corresponding author

Correspondence to Abbas E. Kitabchi.

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This article is part of the Topical Collection on Macrovascular Complications in Diabetes

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Steinberg, H., Jacovino, C. & Kitabchi, A.E. Look Inside Look AHEAD: Why the Glass Is More than Half-Full. Curr Diab Rep 14, 500 (2014). https://doi.org/10.1007/s11892-014-0500-6

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  • DOI: https://doi.org/10.1007/s11892-014-0500-6

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