Abstract
Poorly controlled diabetes before conception and during pregnancy among women with pre-existing diabetes can cause major birth defects and spontaneous abortions, as wells as abnormal fetal growth and development including an offspring who is small or large for gestational age, or predisposed to obesity, type 2 diabetes, and metabolic syndrome in his/her lifetime. Conversely, for a woman with pre-existing diabetes, optimizing blood glucose levels before and during early pregnancy can reduce these risks dramatically. As insulin pump technology has evolved, continuous subcutaneous insulin infusion has become a safe and reliable method for treating diabetes during pregnancy. Although pump therapy is often preferred by patients and some experts, insulin pumps have not yet been shown to be superior to multiple daily injections of insulin during pregnancy. In this review of the literature we focus on the use of insulin pumps in the management of diabetes in pregnancy.
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Jovanovič L, Pettitt DJ. Treatment with insulin and its analogs in pregnancy complicated by diabetes. Diabetes Care. 2007;30:S220–4.
Jovanovič L, Peterson CM, Reed GF, et al. Maternal postprandial blood glucose levels and infant birth weight: the diabetes in early pregnancy study. The national institute of child health and humand development-diabetes in early pregnancy study. Am J Obstet Gynecol. 1991;164:103–11.
Kinsley B. Achieving better outcomes in pregnancies complicated by type 1 and type 2 diabetes mellitus. Clin Ther. 2007;29(Suppl D):S153–60.
Kitzmiller JL, Cloherty JP, Younger MD, et al. Diabetic pregnancy and perinatal outcome. Am J Obstet Gynecol. 1978;131:560–80.
Reece EA, Gabriella S, Abdalla M. The prevention of diabetes associated birth defects. Semin Perinatol. 1988;12:292–302.
Miodovnik M, Lavin JP, Knowles HC, et al. Spontaneous abortion among insulin-dependent diabetic women. Am J Obstet Gynecol. 1984;150:372–5.
Jovanovič L. Prepregnancy counseling and management of women with preexisting diabetes or previous gestational diabetes. In: Jovanovič L, editor. Medical management of pregnancy complicated by diabetes. 4th ed. Virginia: American Diabetes Association Press; 2009.
Wollitzer AD, Zisser H, Jovanovič L. Insulin pumps and their use in pregnancy. Diabetes Technol Ther. 2010;12(Suppl1):33–6.
Dabelea D, Mayer-Davis EJ, Lamichhane AP, et al. Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth the SEARCH case-control study. Diabetes Care. 2008;31(7):1422–6.
Liu LL, Lawrence JM, Davis C, et al. Prevalence of overweight and obesity in youth with diabetes in USA: the SEARCH for diabetes in youth study. Pediatr Diabetes. 2010;11(4):4–11.
Centers for Disease Control and Prevention. National diabetes fact sheet: national estimates and general information on diabetes and prediabetes in the United States, 2011. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2011.
• Castorino K, Jovanovič L.: Pregnancy and diabetes management: advances and controversies. Clin Chem 2011; 57:221–230. This is a review article on the diagnosis and management of diabetes in pregnancy, which provides background information and complements this article.
Misso ML, Egberts KJ, Page M, et al. Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus. Cochrane Database Syst Rev. 2010;1:CD005103.
Petrovski G, Dimitrovski C, Bogoev M, et al.: Is there a difference in pregnancy and glycemic outcome in patients with type 1 diabetes on insulin pump with constant or intermittent glucose monitoring? A pilot study. Diabetes Technol Ther 2011 (Epublish ahead of print).
•• Chico A, Saigi I, Garcia-Patterson A, et al.: Glycemic Control and perinatal outcomes of pregnancies complicated by type 1 diabetes: influence of continuous subcutaneous insulin infusion and lispro insulin. Diabetes Technol Ther 2010; 12:937–945. This is one of the few recent clinical trials evaluating insulin pumps in pregnancy, which had mixed results for CSII compared with MDI.
•• Bruttomesso D, Bonomo M, Costa, the IGCSIIP (Italian Group for Continuous Subcutaneous Insulin Infusion in Pregnancy).: Type 1 diabetes control and pregnancy outcomes in women treated with continuous subcutaneous insulin infusion (CSII) or with insulin glargine and multiple daily injections of rapid-acting insulin analogues (glargine-MDI). Diabetes Metab 2011; [Epub ahead of print]. This is the most recent published clinical trial evaluating CSII in pregnancy and suggests CSII is superior to MDI in quickly achieving glycemic control; however, HbA 1cs were above 6.0% for both groups at delivery.
Hone J, Jovanovič L. Approach to the patient with diabetes during pregnancy. J Clin Endocrinol Metab. 2010;95:3578–85.
Gallen IW, Jaap A, Roland JM, Chirayath HH. Survey of glargine use in 115 pregnant women with Type 1 diabetes. Diabet Med. 2008;25:165–9.
Imbergamo MP, Amato MC, Sciortino G, et al. Use of glargine in pregnant women with type 1 diabetes mellitus: a case-control study. Clin Ther. 2008;30:1476–84.
Castorino K, Wollitzer AO, Pettitt DJ, Zisser H, Jovanovič L.: 50/50 insulin mix 3x per day simplifies insulin regimen in GDM [abstract DIAEAZ 60]. Presented at the 71st Scientific Sessions of the American Diabetes Association. San Diego, California; June 24–28, 2011.
Gabbe SG, Holing E, Temple P, et al. Benefits, risks, costs and patient satisfaction associated with insulin pump therapy for the pregnancy complicated by type 1 diabetes mellitus. Am J Obstet Gynecol. 2000;182:1283–91.
Volpe L, Pancani F, Aragona M, et al. Continuous subcutaneous insulin infusion and multiple dose injections in type 1 diabetic pregnanct women: a case-control study. Gynecol Endocrinol. 2009;31:1–4.
Farrar D, Tuffnell DJ, West J,: Continuous subcutaneous insulin infusion versus multipe daily injections of insulin for pregnant women with diabetes. Cochrane Database Syst Rev 2007; (3):CD005542.
Gabbe SF, Carpenter LB, Garrison EA. New strategies for glucose control in patients with type 1 and type 2 diabetes mellitus in pregnancy. Clin Obstet Gynecol. 2007;50:1014–24.
Hanaire H, Lassmann-Vague V, Jeandidier N, et al. Treatment of diabetes mellitus using an external insulin pump: the state of the art. Diabetes Metab. 2008;34:401–23.
Jovanovič L. Use of insulin during pregnancy in preexisting diabetes. In: Jovanovič L, editor. Medical management of pregnancy complicated by diabetes. 4th ed. Virginia: American Diabetes Association Press; 2009.
Mathiesen ER, Damm P, Jovanovič L, et al.: Clinical experience with basal insulin analogs in diabetic pregnancy: details of a randomized controlled trial in type 1 diabetese and a review of the literature. Diabetes Metab Res Rev 2011. [Epub ahead of print].
Cypryk K, Sobczak M, Pertynska-Marczewska M, et al. Pregnancy complications and perinatal outcome in diabetic women treated with humalog (insulin lispro) or regular human insulin during pregnancy. Med Sci Monit. 2004;10:I29–I132.
Lapolla A, Dalfra MG, Spezia R, et al. Outcome of pregnancy in type 1 diabetic patients treated with insulin lispro or regular insulin: an Italian experience. Acta Diabetol. 2008;45:61–6.
Masson EA, Patmore JE, Brash PD, et al. Pregnancy outcome in type 1 diabetes mellitus treated with insulin lispro (Humalog). Diabet Med. 2003;20:46–50.
Mathiesen ER, Kinsley B, Amiel SA, et al. Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy: a randomized trial of insulin aspart versus human insulin in 322 pregnant women. Diabetes Care. 2007;30:771–6.
Handelsman Y, Blonde L, Bloomgarden Z, et al.: American Academy of Clinical Endocrinologists medical guidelines for clinical practice for developing a diabetes mellitus comprehensive care plan. Endocrine Practice 2011,17(Suppl 2). https://www.aace.com/sites/default/files/DMGuidelinesCCP.pdf.
McCance DR, Damm P, Mathiesen ER, et al. Evaluation of insulin antibodies and placental transfer of insulin aspart in pregnant women with type 1 diabetes mellitus. Diabetologia. 2008;51:2141–3.
Jovanovič L, Druzin M, Peterson CM. Effect of Euglycemia on outcome of pregnancy in insulin-dependent diabetic women as compared to normal control subjects. Am J Med. 1981;71:921–7.
Jovanovič, Lois: Glucose and Insulin Requirements During Labor and Delivery; The Care for Normoglycemia in Pregnancy Complicated by Diabetes. Endocrine Practice 2004, Supplement 2.
de Valk H, Visser GH. Insulin during pregnancy, Labour and delivery. Best Pract Res Clin Obstet Gynaecol. 2011;17:65–76.
Riviello C, Mello G, Jovanovič L. Breastfeeding and the basal insulin requirement in type 1 diabetic women. Endocr Pract. 2009;15:187–93.
• Murphy HR, Elleri D, Allen JM, et al.: Closed-loop insulin delivery during pregnancy complicated by type 1 diabetes. Diabetes Care 2011, 34:406–411. This exciting clinical trial evaluated CSII in conjunction with continuous glucose sensor to form an artificial pancreas system. Although the system did not appropriately treat postprandial hyperglycemia, it offers an attractive solution for the management of insulin-requiring diabetes.
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Conflicts of interest: K. Castorino: has received clinical trial grant support from Sonofi Aventis, NovoNordisk, Dexcom, and Medtronic; R. Paband: none; H. Zisser: has been a consultant for Animas, Insulet, and Roche; has received grant support from Animas, Insulet, Medtronic, and Roche; has received honoraria from Animas, Insulet, and Roche; has received payment for development of educational presentations including service on speakers’ bureaus for Animas, Insulet, and Roche; and has received travel/accommodations expenses covered or reimbursed from Animas, Insulet, and Roche; L. Jovanovič: none.
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Castorino, K., Paband, R., Zisser, H. et al. Insulin Pumps in Pregnancy: Using Technology to Achieve Normoglycemia in Women with Diabetes. Curr Diab Rep 12, 53–59 (2012). https://doi.org/10.1007/s11892-011-0242-7
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DOI: https://doi.org/10.1007/s11892-011-0242-7