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Age-related cardiovascular disease and the beneficial effects of calorie restriction

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Abstract

Aging is a well-recognized risk factor in the development of cardiovascular disease, which is the primary cause of death and disability in the elderly population. The normal process of aging is associated with progressive deterioration in structure and function of the heart and vasculature. These age-related changes likely act as both a catalyst and accelerator in the development of cardiovascular disease. Since the aging population is one of the fastest growing segments of the population, it is of vital importance that we have a thorough understanding of the physiological changes that occur with aging that contribute to the high incidence of cardiovascular disease in this population. This insight will allow for the development of more targeted therapies that can prevent and treat these conditions. One such anti-aging strategy that has received considerable attention as of late is calorie restriction. Calorie restriction has emerged as one of the most effective and reproducible interventions for extending lifespan, as well as protecting against obesity, metabolic disorders, and cardiovascular disease. Herein, we review the multiple beneficial effects that calorie restriction and resveratrol exert on the cardiovascular system with a particular focus on aging. Although calorie restriction and resveratrol have proven to be very effective in preventing and treating the development of cardiovascular disease in animal models, studies continue as to whether these profound beneficial effects can translate to humans to improve cardiovascular health.

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Acknowledgments

This work was supported by grants from the Canadian Institutes of Health Research (CIHR), the Heart and Stroke Foundation of Canada, and the Canadian Diabetes Association. Dr. Dyck is an AHFMR Senior Scholar.

Conflict of interest

Dr. Sung and Dr. Dyck have no conflicts of interest or financial ties to disclose.

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  1. Department of Pediatrics, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, AB, Canada

    Miranda M. Y. Sung & Jason R. B. Dyck

  2. 458 Heritage Medical Research Centre, University of Alberta, Edmonton, AB, T6G 2S2, Canada

    Jason R. B. Dyck

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  1. Miranda M. Y. Sung
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Correspondence to Jason R. B. Dyck.

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Sung, M.M.Y., Dyck, J.R.B. Age-related cardiovascular disease and the beneficial effects of calorie restriction. Heart Fail Rev 17, 707–719 (2012). https://doi.org/10.1007/s10741-011-9293-8

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