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Metoclopramide therapy in patients with delayed gastric emptying

A randomized, double-blind study

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Abstract

Twenty-eight patients with delayed gastric emptying as measured by an abnormal barium “burger” were treated with metoclopramide in a randomized, double-blind fashion. Five had diabetic gastroparesis, four had undergone vagotomy and pyloroplasty, and 19 were idiopathic. Patients received either metoclopramide or placebo for a three-week period and symptoms were scored prestudy, at weekly intervals, and at termination of the study. Ten of 14 patients on metoclopramide and four of 14 on placebo decreased their symptom score to a level below entry criteria, indicating a significant metoclopramide effect when compared to placebo. The mean total symptom score for the metoclopramide group was 18.4 prestudy and 7.2 poststudy while for placebo was 19.1 prestudy and 12.9 poststudy. Although improvement on placebo was significant, these patients were still symptomatic. The improvement on metoclopramide was significantly greater than the improvement on placebo. Metoclopramide is an effective agent in treating the symptom complex of delayed gastric emptying.

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References

  1. Pinder RM, Brodgen RN, Sawyer PR, Speight TM, Avery GS: Metoclopramide: A review of its pharmacological properties and clinical use. Drugs 12:81–131, 1976

    Google Scholar 

  2. Raskin HF: Barium-Burger roentgen study for unrecognized, clinically significant, gastric retention. South Med J 64:1227–1235, 1971

    Google Scholar 

  3. Cooke, AR: Control of gastric emptying and motility. Gastroenterology 68:804–816, 1975

    Google Scholar 

  4. Meeroff JC, Schreiber DS, Trier JS, Blacklow NR: Delayed gastric emptying in acute non-bacterial gastroenteritis. Gastroenterology 74:1066, 1978 (abstract)

    Google Scholar 

  5. Vasconez LO, Adams JT, Woodward ER: Treatment of reluctant postvagotomy stoma with bethanechol. Arch Surg 100:693–694, 1970

    Google Scholar 

  6. Sheiner HT, Catchpole BN: Drug therapy for postvagotomy stasis. Br J Surg 63:608–611, 1976

    Google Scholar 

  7. Johnson AG: Gastroduodenal motility and synchronization. Postgrad Med J (July Suppl.) 29–33, 1973

    Google Scholar 

  8. Eisner M: Effect of metoclopramide on gastrointestinal motility in man. A Manometric study. Am J Dig Dis 16:409–419, 1971

    Google Scholar 

  9. Jacoby HI, Brodie DA: Gastrointestinal actions of metoclopramide. An experimental study. Gastroenterology 52:676–684, 1967

    Google Scholar 

  10. Rees VDW, Go VLW, Malagelada JR: Study of gastric motor activity in diabetic and postvagotomy gastroparesis: Effect of metoclopramide, Gastroenterology 74:1083, 1978 (abstract)

    Google Scholar 

  11. Sethbhakdi S, Sricharoen V, Wilairatnna S: The effect of metoclopramide on gastric emptying. Am J Proctol 26:51–59, 1975

    Google Scholar 

  12. Hancock BD, Bowen-Jones E, Dixon R, Dymock W, Cowley DJ: The effect of metoclopramide on gastric emptying of solid meals. Gut 15:462–467, 1974

    Google Scholar 

  13. Metzger WH, Cano R, Sturdevant RAL: Effect of metoclopramide in chronic gastric retention after gastric surgery. Gastroenterology 71:30–32, 1976

    Google Scholar 

  14. Perkel MS, Fajman W, Hersh T, Moore C, Davidson E: Comparison of gastric emptying as measured by the barium burger and gamma camera tests: Effects of metoclopramide. Gastroenterology 74:1076, 1978 (abstract)

    Google Scholar 

  15. Eisner M: Gastrointestinal effects of metoclopramide in man.In vitro experiments with human smooth muscle preparation. Br Med J 4:679, 1968

    Google Scholar 

  16. Hay AM: Pharmacological analysis of the effects of metoclopramide on the guinea pig isolated stomach. Gastroenterology 72:864–869, 1977

    Google Scholar 

  17. Dolphin A, Jenner P, Marsden CD, Pycock C, Tarsy D: Pharmacological evidence for cerebral dopamine receptor blockade by metoclopramide in rodents. Psychopharmacologia 41:133–138, 1975

    Google Scholar 

  18. Valenzuela JE: Dopamine as a possible neurotransmitter in gastric relaxation. Gastroenterology 71:1019–1022, 1976

    Google Scholar 

  19. Brownlee M, Kroopf SS. Metoclopramide for gastroparesis diabeticorum. N Engl J Med 291:1257–1258, 1974

    Google Scholar 

  20. Longstreth GF, Malagelada JR, Kelly KA: Metoclopramide stimulation of gastric motility and emptying in diabetic gastroparesis. Ann Intern Med 86:195–196, 1977

    Google Scholar 

  21. Hartong WA, Moore J, Booth JP: Metoclopramide in diabetic gastroparesis. Ann Intern Med 86:826, 1977

    Google Scholar 

  22. Davidson ED, Hersh T, Haun C, Brooks WS: Use of metoclopramide in patients with delayed gastric emptying following gastric surgery. Am Surg 43:40–44, 1977

    Google Scholar 

  23. Stadaas SO, Aune S: Clinical trial of metoclopramide in postvagotomy gastric stasis. Arch Surg 104:684, 1972

    Google Scholar 

  24. Berkowitz DM, Metzger WH, Sturdevant RAL: Oral metoclopramide in diabetic gastroparesis and in chronic gastric retention after gastric surgery. Gastroenterology 70:863, 1976 (abstract)

    Google Scholar 

  25. Johnson AG: Flatulent dyspepsia. Postgrad Med J (July Suppl.) 104–106, 1973

    Google Scholar 

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Authors and Affiliations

  1. Division of Digestive Diseases, Department of Medidine, Emory University School of Medicine, Atlanta, Georgia

    Michael S. Perkel MD, Caroline Moore BA, Theodore Hersh MD & Eugene D. Davidson MD

Authors
  1. Michael S. Perkel MD
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  2. Caroline Moore BA
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  3. Theodore Hersh MD
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  4. Eugene D. Davidson MD
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Perkel, M.S., Moore, C., Hersh, T. et al. Metoclopramide therapy in patients with delayed gastric emptying. Digest Dis Sci 24, 662–666 (1979). https://doi.org/10.1007/BF01314461

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