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04-18-2018 | Type 2 diabetes | Review | Article

Pediatric Type 2 Diabetes in Japan: Similarities and Differences from Type 2 Diabetes in Other Pediatric Populations

Journal: Current Diabetes Reports

Author: Tatsuhiko Urakami

Publisher: Springer US

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Abstract

Purpose of Review

To review clinical characteristics of pediatric type 2 diabetes in Japan.

Recent Findings

It is well recognized that Asian populations, particularly the Japanese, have a higher incidence of childhood type 2 diabetes. Of note, most Asian populations show a higher incidence of pediatric type 2 diabetes than that of type 1 diabetes. However, a current report in the USA demonstrated a dramatic increase in the incidence of young people with type 2 diabetes in recent years. The USA could have a much higher incidence of type 2 diabetes than Japan, possibly due to environmental and behavioral factors. The clinical features of Japanese young people with type 2 diabetes might have some differences from type 2 diabetes in other pediatric populations. Japanese children with type 2 diabetes are likely to be thinner than Caucasian children. Approximately 10–15% Japanese patients with type 2 diabetes exhibit normal weight with milder insulin resistance and substantial insulin secretion failure. Autoimmunity is not associated with the etiology of type 2 diabetes.

Summary

Some genetic background and environmental factors, different from those in Caucasians, could play a role in the development of type 2 diabetes in Japanese children. Considering these characteristics, we must consider adequate therapy and management for young people with type 2 diabetes.
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