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Type 1 diabetes

Pathogenesis

09-07-2022 | Pathogenesis | News

CLOuD: Early and sustained closed-loop therapy does not stave off beta-cell decline

Starting young people on closed-loop insulin delivery within 21 days after type 1 diabetes diagnosis does not slow the decline in their C-peptide levels over the next 12 months, report the CLOuD investigators.

Syringe and glucometer on a table - blood sugar in diabetes concept

06-14-2022 | Pathogenesis | News

People with ‘low BMI diabetes’ have a unique metabolic profile

Researchers have characterized an atypical form of diabetes in Indian men with low BMI, which has a unique metabolic profile setting it apart from type 1 and type 2 diabetes.

01-06-2022 | Pathogenesis | News

Genetic study backs role for liver fat, pancreatic volume in type 2 diabetes risk

A genetic propensity for increased liver fat and lower pancreatic volume is associated with an increased risk for type 2 diabetes, say researchers.

07-23-2021 | Children | News

Autoantibody variation at seroconversion may indicate future diabetes risk in children

Children at increased genetic risk for type 1 diabetes are more likely to develop the condition if they have multiple, rather than single, islet autoantibodies present at the time of seroconversion, a combined analysis of prospective cohorts shows.

10-23-2020 | Pathogenesis | News

Type 1 diabetes identified in earliest weeks of life

Researchers have identified infants as young as 3 months with probable type 1 diabetes, raising the possibility that the disease process could in some cases begin before birth.

Close-up of microscope

03-16-2020 | Pathophysiology | Highlight | News

Type 1 diabetes endotypes firmed up

Researchers provide further evidence to support two distinct type 1 diabetes endotypes characterized by a more or less aggressive autoimmune response and a younger or older age at onset.

Overweight boy in a tight shirt

02-14-2020 | Pathogenesis | Highlight | News

Excess weight may hasten type 1 diabetes progression in lower-risk children

A high BMI may contribute to the risk for progressing from single to multiple islet autoantibodies, especially in children who would otherwise be at relatively low risk, show findings from TrialNet.

neurotransmission

09-18-2019 | Pathogenesis | EASD 2019 | News

Trial shortcomings make GABA benefits unclear in early type 1 diabetes

The limitations of a clinical trial of gamma aminobutyric acid on the progression of newly diagnosed type 1 diabetes may have precluded any positive results, say the researchers.

06-21-2019 | Pathogenesis | News

Rotavirus vaccination linked to reduced type 1 diabetes risk

Findings from a US cohort study suggest that children who have received rotavirus vaccination have a significantly lower risk for developing type 1 diabetes than those who have not been given the vaccine.

Lymphocyte

06-05-2019 | Pathophysiology | Highlight | News

Hybrid immune cell could contribute to type 1 diabetes autoimmunity

Researchers have discovered an immune cell with the attributes of both B cells and T cells, which is present in increased frequency in some people with type 1 diabetes and capable of activating insulin-specific T-helper cells.

06-22-2018 | Gastroparesis | Review | Article

Diabetic gastroparesis: Principles and current trends in management

Krishnasamy S, Abell TL. Diabetes Ther (2018); 9 (Suppl 1): 1. doi: 10.1007/s13300-018-0454-9

06-14-2018 | Other types of diabetes | Review | Article

Type 1 diabetes in a resource-poor setting: Malnutrition related, malnutrition modified, or just diabetes?

Balcha SA, Phillips DI, Trimble ER. Curr Diab Rep 2018; 18: 47. doi: 10.1007/s11892-018-1003-7

04-25-2018 | Bone health | Review | Article

Diabetes mellitus and bone health: Epidemiology, etiology and implications for fracture risk stratification

Valderrábano RJ, Linares MI. Clin Diabetes Endocrinol 2018; 4: 9. doi: 10.1186/s40842-018-0060-9

Subgroups concept image (symbolic image with model)

03-02-2018 | Pathogenesis | Highlight | News

Five diabetes classifications could help focus treatment

Researchers have identified five clusters of adult diabetes patients that have distinctly different disease progression and risk for complications.

Potential roles of autoreactive B cells in diabetic kidney disease

10-17-2017 | Nephropathy | Review | Article

B cells in type 1 diabetes mellitus and diabetic kidney disease

Nat Rev Nephrol 2017; 13: 712–720. doi: 10.1038/nrneph.2017.138

New Content Item

09-15-2017 | Neuropathy | Review | Article

CIDP and other inflammatory neuropathies in diabetes: Diagnosis and management

​​​​​​​Nat Rev Neurol 2017; 13: 599–611. doi: 10.1038/nrneurol.2017.123

09-08-2017 | Latent autoimmune diabetes of adulthood | Review | Article

Adult-onset autoimmune diabetes: Current knowledge and implications for management

Nat Rev Endocrinol 2017; 13: 674–686. doi: 10.1038/nrendo.2017.99

05-11-2017 | Children | News

Fatty acids consumed during breastfeeding could protect against type 1 diabetes

Fatty acids derived from fish and consumed during breastfeeding may protect against the development of type 1 diabetes-associated autoimmunity, researchers report.

04-13-2017 | Children | News

Immunological, genetic factors associated with rapid progression to type 1 diabetes

Study results suggest that autoantibody-positive children who progress rapidly to type 1 diabetes have higher antibody titers and distinct genetic characteristics compared with those who develop the disease more slowly or do not progress to diabetes.