Type 1 diabetes diagnosis

Type 1 diabetes onset may be more common during adulthood than previously thought, which could increase the risk for it being misdiagnosed as type 2 diabetes.

“Almost no one” who is islet autoantibody negative at age 10 years despite a high familial risk for type 1 diabetes will develop clinical diabetes by the age of 18, report researchers.

Analysis of childhood type 1 diabetes diagnoses across 13 countries indicates that the conditions created by the COVID-19 pandemic worsened pre-existing increasing trends in ketoacidosis at diagnosis.

Testing positive for SARS-CoV-2 is associated with an increased risk for incident type 1 diabetes, but this is restricted to the first 30 days post-infection and may be explained by increased testing frequency around the time of diabetes diagnosis, researchers report.

Testing high-risk children for islet autoantibodies twice, at the ages of 2 and 6 years, is sufficient to predict the majority of clinical cases of type 1 diabetes diagnosed by the age of 15, a study suggests.

Transdermal capillary blood collection produces samples in which C-peptide can be reliably measured, removing the need for venous blood sampling, report researchers.

Researchers have developed a machine-learning tool that could predict a type 1 diabetes diagnosis in children on the basis of data from primary care electronic health records.

Children with islet autoantibodies who spend more than 10% of their time with hyperglycemic glucose levels are highly likely to progress to clinical diabetes within the next year, show findings from the ASK study.

The age at diagnosis of type 1 diabetes has decreased substantially across successive generations, show study findings presented at the virtual 57th EASD Annual Meeting.

Children at increased genetic risk for type 1 diabetes are more likely to develop the condition if they have multiple, rather than single, islet autoantibodies present at the time of seroconversion, a combined analysis of prospective cohorts shows.

A majority of adults with clinically diagnosed type 1 diabetes but no islet autoantibodies have a low genetic risk for the condition, suggesting misdiagnosis, report researchers.

Researchers have identified a marked increase in the proportion of children and adolescents who have diabetic ketoacidosis at the point of type 1 diabetes diagnosis during the COVID-19 pandemic.

Beta-cell function enters a period of rapid decline around 6 months before people meet the diagnostic threshold for type 1 diabetes, show TrialNet data.

Research shows that being diagnosed with type 1 diabetes after the age of 30 years is relatively common, yet people are often misdiagnosed with type 2 diabetes, despite rapid progression to insulin dependence.

Data from the TrialNet Pathway to Prevention study shows that monitoring high-risk relatives of people with type 1 diabetes markedly reduces the risk for those who develop the condition presenting with diabetic ketoacidosis.

Measuring C-peptide in everyone a minimum of 3 years after a clinical diagnosis of type 1 diabetes can result in some people being reclassified with other forms of diabetes, researchers report.

It is just as important to help adults with newly diagnosed type 1 diabetes learn how to live with the condition as it is to teach them about it, show results of a narrative study among patients from the UK and Denmark.

Researchers have developed a prediction model combining clinical features, autoantibodies, and genetics to help distinguish patients with type 1 diabetes from those with type 2 diabetes.

Around two in five cases of type 1 diabetes are diagnosed in patients older than 30 years but may be hard to spot against the background of high type 2 diabetes prevalence, show findings from the UK Biobank.

Glycated hemoglobin levels are higher for a given blood glucose level in Black patients with diabetes than they are in White people, shows a continuous glucose monitoring study.

Read the linked commentary from Jay Shubrook.