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HFpEF 

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  1. 11-18-2022 | Dapagliflozin | News | Article

    Dapagliflozin HFpEF benefits independent of glucose levels

    They also highlight the high prevalence of dysglycemia among people with HFpEF and the particularly large absolute benefit of dapagliflozin in people with type 2 diabetes.

  2. 08-27-2022 | Dapagliflozin | News | Article

    Dapagliflozin DELIVERs improved HFpEF outcomes

    medwireNews : Dapagliflozin significantly reduces the risk for worsening heart failure or cardiovascular death in people who have heart failure with preserved ejection fraction (HFpEF), show the results of the DELIVER trial.

  3. 10-28-2021 | Dapagliflozin | News | Article

    PRESERVED-HF: Dapagliflozin improves health status in people with HFpEF

    For the phase 4 trial, 324 individuals with chronic, symptomatic HFpEF on standard therapy were randomly assigned to receive 12 weeks of once-daily treatment with dapagliflozin 10 mg or placebo.

  4. play
    11-01-2021 | Dapagliflozin | Commentary | Video

    PRESERVED-HF: Support for dapagliflozin to improve HFpEF health status

    Mikhail Kosiborod outlines the findings from the PRESERVED-HF trial, demonstrating that dapagliflozin improves symptoms and physical function in people with heart failure with preserved ejection fraction, and discusses the promise of SGLT2 inhibitors for meeting the treatment goals in this population (9:35).  00:00 Introduction 02:12 Key findings from PRESEVED-HF 04:42 How dapagliflozin compares with other HFpEF medications 07:08 Conclusions so far on SGLT2 inhibitors in HFpEF

  5. 08-29-2021 | ESC 2021 | News | Article

    Empagliflozin has broad beneficial effect on HFpEF outcomes

    Empagliflozin treatment produces significant reductions in the risk for a broad range of inpatient and outpatient heart failure outcomes in people with a preserved ejection fraction, shows further analysis of EMPEROR-Preserved.

  6. 08-27-2021 | ESC 2021 | News | Article

    EMPEROR-Preserved: A win for empagliflozin in HFpEF

    medwireNews : Empagliflozin has become the first medication to demonstrate a clear protective effect in people with heart failure and preserved ejection fraction (HFpEF), report the EMPEROR-Preserved investigators.

  7. play
    08-29-2021 | ESC 2021 | Conference coverage | Video

    EMPEROR-Preserved: Diabetes medication becomes first effective HFpEF therapy

    ESC 2021 video: EMPEROR-Preserved: Diabetes medication becomes first effective HFpEF therapy.

  8. 12-06-2022 | Empagliflozin | News | Article
    News in brief

    Empagliflozin benefits supported for mid-range ejection fraction

    The trial included 4005 people with HF and preserved LVEF (≥50%; HFpEF) and 1983 in whom it was mildly reduced (41–49%; HFmrEF).

  9. 10-14-2020 | Tirzepatide | At a glance | Article
    Updated April 2023

    A quick guide to the SURPASS and SURMOUNT trials

    Phase 3 and 4 trials of tirzepatide in type 2 diabetes and obesity

    A trial of tirzepatide for HFpEF SUMMIT: Recruiting Trial population: People with obesity plus HFpEF Comparator treatment: Placebo NCT04847557 ; estimated study completion in November 2023 In this trial, people with obesity plus HFpEF (heart failure with preserved ejection fraction) will take tirzepatide or placebo for 52 weeks.

  10. 09-02-2022 | Dapagliflozin | News | Article

    DELIVER results round-up: Frailty, AF, recent hospitalization, and more

    medwireNews : A flurry of publications accompanying the primary findings of DELIVER shows dapagliflozin to benefit a wide range of people who have heart failure with preserved ejection fraction (HFpEF).

  11. 12-20-2022 | Dapagliflozin | News | Article
    approvalsWatch

    Dapagliflozin on way to EC approval for all heart failure

    Click through to read more on this announcement

  12. 12-17-2021 | Heart failure | News | Article

    Metformin, but not sulfonylurea, may reduce poor outcome risk post HHF

    Specifically, individuals with HF and a preserved EF (HFpEF; >40%) had a significant 32% lower risk for the composite of death or HHF and a significant 42% lower risk for HHF alone with metformin use relative to no use, whereas there was no benefit to metformin initiation among the subgroup with HF and a reduced EF (HFrEF; ≤40%).

  13. 02-11-2021 | Semaglutide | At a glance | Article
    Updated April 2023

    A quick guide to the STEP trials

    Related news story:  STEP TEENS: High-dose semaglutide weight loss benefits shown in adolescents STEP HFpEF DM: Recruiting Trial population: Overweight or obese people with type 2 diabetes and heart failure with preserved ejection fraction Comparator treatment: Placebo NCT04916470 This trial, aiming to enroll 610 participants, is testing whether weight loss with semaglutide is accompanied by improved heart failure symptoms in people with symptomatic heart failure with preserved ejection fraction.

  14. 08-31-2022 | Heart failure | News | Article

    ‘Strikingly consistent’ evidence for SGLT2 inhibitor benefits across the spectrum of heart failure

    SGLT2 inhibitors reduce the risk for adverse outcomes in a broad range of patients with heart failure, suggest findings from a meta-analysis of five randomized placebo-controlled trials.

  15. play
    03-02-2022 | Empagliflozin | Video

    EMPULSE: The ‘missing link’ for empagliflozin in heart failure

    Adriaan Voors discusses the EMPULSE trial of empagliflozin given just after stabilization of de novo or decompensated chronic heart failure.

  16. 02-28-2022 | Empagliflozin | News | Article

    EMPULSE shows empagliflozin benefit in acute heart failure

    Starting empagliflozin as soon as feasible after hospital admission for acute heart failure reduces symptom burden and the risk for repeat episodes and mortality over the following 3 months, report the EMPULSE investigators.

  17. 03-01-2022 | Empagliflozin | News | Article
    approvalsWatch

    Empagliflozin indication extended to all heart failure in USA

    Click through to read more on this announcement

  18. 02-28-2022 | Canagliflozin | News | Article

    Virtual CHIEF-HF trial supports canagliflozin in heart failure

    The virtual CHIEF-HF trial has demonstrated a significant positive effect of canagliflozin on heart failure symptoms without the need for in-person clinic visits, the investigators report in Nature Medicine .

  19. 11-19-2020 | Heart failure | News | Article

    Targeting fat mass, central adiposity may reduce HF risk in type 2 diabetes

    By contrast, a 10% reduction in waist circumference over 1 year was associated with a significant 39% lower risk for HFpEF but there was no association with HFrEF.

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