But by the time of the second exam, at an average age of just 25.4 years, 49% had diabetic retinopathy, with 1.4% having progressed to severe nonproliferative retinopathy, 2.7% to early or stable treated proliferative retinopathy, and 1.0% to high-risk proliferative retinopathy.

But age at diabetes onset modified the dementia risk.

Younger age at onset of type 2 diabetes is associated with a significantly increased risk for cardiovascular death, as well as an increased likelihood of having offspring who will also develop diabetes, Framingham Heart Study data show.

The development of type 2 diabetes at a young age disproportionately affects people of South Asian and African–Caribbean ethnicity, and obesity is associated with early-onset diabetes in all ethnic groups, indicates research presented at the virtual 56th EASD Annual Meeting.

The “classic” metabolic contributors to early-onset type 2 diabetes risk in European people explain little of the risk in Asian people, shows a comparison of Scottish and Asian Indian cohorts.

Research suggests that individuals with adult-onset type 1 diabetes could benefit from more intense monitoring, as only a minority meet recommended targets for glycemic control despite initial improvements, while at the same time the majority become overweight or obese.

. © 2019 Springer Healthcare part of the Springer Nature group Circulation 2019; doi:10.1161/CIRCULATIONAHA.118.037885 See also: Longer duration of type 2 diabetes associated with higher mortality risk Early diabetes onset linked to increased mortality risk High risk with earlier diabetes onset seen in older population

Study results presented at the 2018 Diabetes UK Professional Conference in London confirm that people who are diagnosed with type 2 diabetes at a younger age have an increased mortality risk.

The differences were also independent of socioeconomic variables and country of birth, say Soffia Gudbjörnsdottir (University of Gothenburg, Sweden) and co-researchers, and therefore “support the notion that early-onset type 2 diabetes may be a more pathogenic condition per se than later-onset type 2 diabetes.”

But the editorialists were concerned by “the fact that the incidence of type 1 diabetes appears to be increasing, with apparent disparities among ethnic groups that are not likely to be explained by the obesity epidemic,” and pose the question: “What will happen to the increasing number of persons with early-onset diabetes as they age?”

“Therefore, weight control and management are essential in reducing the burden of early onset type 2 diabetes,” say the researchers.

Early treatment with the anti-CD3 monoclonal antibody teplizumab may help to preserve β-cell function in children and adolescents with newly diagnosed type 1 diabetes, results of the phase 3 PROTECT study show.

Mutations in the ONECUT1 gene can underlie neonatal diabetes and contribute to the risk for early-onset type 2 diabetes, research shows.

Chinese people with new-onset type 2 diabetes have a significantly increased risk for pancreatic cancer relative to the general population, particularly when they are diagnosed at a young age, study findings indicate.

However, the field is at a relatively early stage, with the vast majority of published studies being phase 2 or earlier.

Who is at the highest risk for developing type 2 diabetes in their youth? 

And they add that, given the poor cardiovascular risk profile in people with young-onset type 2 diabetes , “the non-glycaemic benefits of dapagliflozin reported in adults with or without type 2 diabetes, is an important consideration.” medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2022 Springer Healthcare Ltd, part of the Springer Nature Group Lancet Diabetes Endocrinol 2022; doi:10.1016/S2213-8587(22)00052-3 Lancet Diabetes Endocrinol 2022; doi:10.1016/S2213-8587(22)00075-4

Type 2 diabetes in young, lean people is much more common in Asian Indians than in White Europeans, say researchers who found that genetically determined beta-cell function may be to blame.

Children born to mothers with diabetes have a higher risk for early-onset, non-congenital cardiovascular disease in childhood and early adulthood than those born to mothers without diabetes, suggest findings from a large observational study.