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Gastrointestinal disorders

Gastrointestinal disorders

09-20-2022 | EASD 2022 | Conference coverage | News

Fatty liver index may predict mortality, CVD risk in people with type 1 diabetes

Hepatic steatosis, measured by the fatty liver index, is associated with an increased risk for mortality and cardiovascular disease among people with type 1 diabetes, research suggests.

09-20-2022 | EASD 2022 | Conference coverage | News

Insulin pump delivery may reduce fatty liver risk in type 1 diabetes

Using an insulin pump rather than multiple daily injections may help protect people with type 1 diabetes from developing fatty liver disease, report researchers.

06-22-2022 | SGLT2 inhibitors | News

SGLT1/2 inhibitor shows early promise in NASH

The SGLT1/2 inhibitor licogliflozin has reduced liver enzyme levels in people with nonalcoholic steatohepatitis in a phase 2 trial published in Nature Medicine.

06-05-2022 | ADA 2022 | Conference coverage | News

Almost any liver fat may be abnormal

Researchers report that metabolic abnormalities begin to increase at levels of liver fat commonly regarded as normal.

Overweight person and injection pen

04-27-2022 | Tirzepatide | News

Tirzepatide reduces liver fat, improves time in range

The publication of two SURPASS-3 substudies in The Lancet Diabetes & Endocrinology reveals significant benefits of tirzepatide on liver and abdominal fat in people with type 2 diabetes, as well as on time in target glucose range.

02-04-2022 | Non-alcoholic fatty liver disease | News

Doctors call for NAFLD care pathway in type 2 diabetes

Physicians feel that nonalcoholic fatty liver disease is sidelined in type 2 diabetes management and should be formally incorporated into routine primary care pathways, say Australian researchers.

01-06-2022 | Pathogenesis | News

Genetic study backs role for liver fat, pancreatic volume in type 2 diabetes risk

A genetic propensity for increased liver fat and lower pancreatic volume is associated with an increased risk for type 2 diabetes, say researchers.

11-29-2021 | Metabolic surgery | News

Rival gastric surgery approaches have similar effects on liver fat

Gastric bypass and sleeve gastrectomy both result in “almost complete clearance of liver fat” within a year after the intervention, show secondary outcomes of a randomized trial.

09-09-2021 | Non-alcoholic fatty liver disease | News

Fatty liver index may predict progression to type 2 diabetes

The degree of non-alcoholic fatty liver disease, estimated by fatty liver index, is significantly associated with the risk for progression to type 2 diabetes in people with prediabetes, Spanish study findings indicate.

05-28-2021 | Non-alcoholic fatty liver disease | News

Visceral obesity flags NAFL risk in type 1 diabetes

Visceral adipose tissue is strongly indicative of the presence of non-alcoholic fatty liver in people with type 1 diabetes, but fat in other areas is not, show findings from the FinnDiane study.

01-08-2021 | Non-alcoholic fatty liver disease | News

Liver fibrosis common in type 2 diabetes

Researchers have detected moderate or severe liver fibrosis in around one in six people with type 2 diabetes.

11-13-2020 | Semaglutide | News

Semaglutide treatment may reverse NASH

Treatment with semaglutide can lead to resolution of nonalcoholic steatohepatitis in people with or without type 2 diabetes, show phase 2 trial findings, although a question mark remains over its effect on fibrosis.

09-18-2020 | Dulaglutide | News

Add-on dulaglutide may reduce liver fat in people with type 2 diabetes, NAFLD

Results from the D-LIFT trial suggest a reduction in liver fat content when dulaglutide, a glucagon-like peptide-1 receptor agonist, is added to standard care treatment in people with concurrent type 2 diabetes and non-alcoholic fatty liver disease.

05-28-2020 | Gastrointestinal disorders | News

‘High rates’ of asymptomatic celiac disease in people with type 1 diabetes

Asymptomatic celiac disease is a frequently occurring comorbidity in people with type 1 diabetes, and transitioning to a gluten-free diet may increase postprandial glycemic variability, researchers report.

Gastric bypass surgery (used with permission)

08-12-2019 | Metabolic surgery | Highlight | News

Bariatric surgery linked to late adverse events

People who undergo bariatric surgery have a lower long-term risk for mortality, but a higher risk for adverse events such as gastrointestinal and nutritional disorders, compared with those who do not undergo surgery, researchers report.

Read the linked commentary from John Wilding

05-24-2019 | Non-alcoholic fatty liver disease | News

Diabetes patients at high risk of serious NAFLD outcomes

People with non-alcoholic fatty liver disease or non-alcoholic steatohepatitis are at particularly high risk for progression to cirrhosis or hepatocellular carcinoma if they have diabetes, say researchers.

12-05-2018 | Non-alcoholic fatty liver disease | Article

A round trip from nonalcoholic fatty liver disease to diabetes: molecular targets to the rescue?

Lonardo A, Lugari S, Ballestri S et al. Acta Diabetol 2018. doi: 10.1007/s00592-018-1266-0

06-22-2018 | Gastroparesis | Review | Article

Diabetic gastroparesis: Principles and current trends in management

Krishnasamy S, Abell TL. Diabetes Ther (2018); 9 (Suppl 1): 1. doi: 10.1007/s13300-018-0454-9

GI pain concept (symbolic image with model)

06-01-2018 | Gastrointestinal disorders | Highlight | News

High burden of GI symptoms in patients with type 1 diabetes

People with type 1 diabetes are approximately twice as likely to experience gastrointestinal symptoms as those without, and these symptoms are associated with poor glycemic control and quality of life, study results suggest.