Genetics

A family history of diabetes is associated with a younger age at type 2 diabetes diagnosis, but this could be delayed by following a healthy lifestyle, suggest data from the Joint Asia Diabetes Evaluation Register.

Mutations in the ONECUT1 gene can underlie neonatal diabetes and contribute to the risk for early-onset type 2 diabetes, research shows.

Sanjay Kalra reports back from the 2021 South Asian Federation of Endocrine Societies summit.

Combining 10 weighted polygenic risk scores of variants related to cardiovascular and renal complications in a joint model with traditional risk factors could optimize micro- and macrovascular risk prediction and treatment response in type 2 diabetes, say researchers.

The effect of common genetic variants on the risk for type 2 diabetes is markedly stronger for youth-onset than adult-onset disease, report researchers.

Extremes of bodyweight and high glycated hemoglobin levels were two of the factors linked to rapid glycemic progression in a study of more than 7000 Chinese people with type 2 diabetes.

A major genetic analysis sheds light on the similarities and differences in type 2 diabetes pathogenesis between people of East Asian and European origin.

A Mendelian randomization analysis supports a direct effect of major depressive disorder on type 2 diabetes risk, but produces no evidence for the reverse scenario.

Risk alleles for type 2 diabetes influence the risk for women developing the condition after experiencing gestational diabetes, say researchers.

Genetics and dietary fat each influence people’s risk for developing type 2 diabetes, but without any interaction between the two, show the findings of an individual participant data meta-analysis.

People with type 2 diabetes have a high prevalence of pathogenic mutations in genes typically associated with monogenic diabetes.

Researchers have used exome-wide sequencing to identify several rare variants within four genes that are significantly associated with type 2 diabetes.

Katamitri A, Jockers R. Nat Rev Endocrinol 2018. doi: 10.1038/s41574-018-0130-1

Researchers have identified a haplotype of three missense mutations in the sodium-glucose cotransporter-1 gene that is associated with a reduced risk for impaired glucose tolerance, diabetes, and obesity.

The UKPDS has so far generated an astonishing 93 original research papers. medwireNews​​​​​​​ rounds them up.

A healthy lifestyle bestows the same degree of relative risk reduction for type 2 diabetes irrespective of whether people have high or low genetic risk for the condition, shows an analysis of UK Biobank data.

Strawbridge RJ, van Zuydam NR. Curr Diab Rep 2018; 18: 59. doi: 10.1007/s11892-018-1021-5

Sarnowski C, Hivert MF. Curr Diab Rep 2018; 18: 52. doi: 10.1007/s11892-018-1022-4

Aydin Ö, Nieuwdorp M, Gerdes V. Curr Diab Rep 2018; 18: 55. doi: 10.1007/s11892-018-1020-6

Wittemans LBL, Lotta LA, Langenberg C. Curr Diab Rep 2018; 18: 40. doi: 10.1007/s11892-018-1009-1