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11-23-2016 | Specific populations | Book chapter | Article

13. Diabetes Among Indigenous Canadians

Authors: Sudaba Mansuri, MSc, Anthony J. Hanley

Publisher: Springer International Publishing

Abstract

Type 2 diabetes mellitus (DM) has been increasing dramatically in the Indigenous population of Canada over the past six decades, with the prevalence of this condition reaching epidemic levels in many communities. The burden of complications related to type 2 DM is also disproportionately higher among Indigenous Canadians compared to their non-Indigenous counterparts, which has created a major clinical and public health challenge for this population. Indigenous Canadians also suffer from a higher prevalence of cardiometabolic and lifestyle risk factors for type 2 DM such as hypertension, obesity, suboptimal eating patterns, low physical activity, and smoking. Many of these factors exist on a background of (and are exacerbated by) poverty, poor housing, low educational attainment, unemployment, inadequate community resources, and suboptimal clinical care. Although recent advances in community-based interventions targeting physical activity and healthy eating practices have led to improvements in health and well-being in specific communities, lack of environmental and social support for these practices on a broader scale remains an ongoing challenge. Consequently, sustainable and broadly implemented interventions targeting type 2 DM primary and secondary prevention in Indigenous Canadians are vital. In particular, culturally appropriate primary prevention programs and clinical care strategies that include the participation of Indigenous community members is crucial for relieving the heavy burden of type 2 DM and its complications in this population.
Literature
1.
Public Health Agency of Canada. Diabetes in Canada: facts and figures from a public health perspective. Ottawa: Public Health Agency of Canada; 2011.
2.
Friesen JW. Rediscovering the First Nations of Canada. Chicago: Detselig Enterprises Limited; 1997.
3.
Statistics Canada. Aboriginal peoples in Canada: first nations people, Métis and Inuit: National Household Survey, 2011. Ottawa: Minister of Industry; 2011. 978-1-100-22203-5.
4.
Lischke U, McNab DT. The long journey of a forgotten people: Métis identities and family histories. Waterloo: Wilfrid Laurier University Press; 2007.
5.
Stern PR. Historical dictionary of the Inuit. Lanham: Scarecrow Press; 2013.
6.
Langlois S, Turner A. In: Canada S, editor. Aboriginal languages in Canada. Ottawa: Minister of Industry; 2012.
7.
Malenfant EC, Morency JD. Population projections by Aboriginal Identity in Canada, 2006 to 2031. Statistics Canada; 2011.
8.
Statistics Canada. Aboriginal peoples in Canada: First nations people, Métis and Inuit: National household survey, 2011;99 - 011 - X2011001. Canada: Minister of Industry; 2013.
9.
Reading CL, Wien F. Health inequalities and social determinants of aboriginal people’s health. Prince George: National Collaborating Centre for Aboriginal Health; 2009.
10.
Young TK, Reading J, Elias B, O’Neil JD. Type 2 diabetes mellitus in Canada’s First nations: status of an epidemic in progress. CMAJ. 2000;163(5):561–6.PubMedPubMedCentral
11.
Reading J. The crisis of chronic disease among aboriginal peoples: a challenge for public health, population health and social policy. Victoria: Centre for Aboriginal Health Research: University of Victoria Press; 2009.
12.
Chase LA. The trend of diabetes in Saskatchewan, 1905 to 1934. Can Med Assoc J. 1937;36(4):366–9.PubMedPubMedCentral
13.
Montour LT, Macaulay AC. High prevalence rates of diabetes mellitus and hypertension on a North American Indian reservation. Can Med Assoc J. 1985;132(10):1110, 2.PubMedPubMedCentral
14.
Evers S, McCracken E, Antone I, Deagle G. The prevalence of diabetes in Indians and Caucasians living in Southwestern Ontario. Can J Public Health. 1987;78(4):240–3.PubMed
15.
Young TK, Szathmary EJ, Evers S, Wheatley B. Geographical distribution of diabetes among the native population of Canada: a national survey. Soc Sci Med. 1990;31(2):129–39.PubMedCrossRef
16.
Brassard P, Robinson E, Lavallée C. Prevalence of diabetes mellitus among the James Bay Cree of northern Quebec. CMAJ. 1993;149(3):303–7.PubMedPubMedCentral
17.
Pioro MP, Dyck RF, Gillis DC. Diabetes prevalence rates among First Nations adults on Saskatchewan reserves in 1990: comparison by tribal grouping, geography and with non-First Nations people. Can J Public Health. 1996;87(5):325–8.PubMed
18.
Fox C, Harris S, Whalen-Brough E. Diabetes among Native Canadians in northwestern Ontario: 10 years later. Chron Dis Canada. 1994;15:92–6.
19.
Office of the Auditor General of Canada. Chapter 4, Programs for First Nations on Reserves, of the 2011 Report of the Auditor General of Canada. In: Standing Committee on Public Accounts. Status Report of the Auditor General of Canada to the House of Commons. Report. Ottawa, Canada; 2011.
20.
First Nations Information Governance Canada. First Nations regional longitudinal health survey (RHS) 2002/03: results for adults, youth and children living in first nations communities. Ottawa: Assembly of First Nations, First Nations Information Governance Centre; 2007.
21.
Statistics Canada. Canadian Community Health Survey (CCHS); 2011.
22.
Green C, Blanchard JF, Young TK, Griffith J. The epidemiology of diabetes in the Manitoba-registered First Nation population: current patterns and comparative trends. Diabetes Care. 2003;26(7):1993–8.PubMedCrossRef
23.
Dyck R, Osgood N, Lin TH, Gao A, Stang MR. Epidemiology of diabetes mellitus among First Nations and non-First Nations adults. CMAJ. 2010;182(3):249–56.PubMedPubMedCentralCrossRef
24.
Oster RT, Johnson JA, Hemmelgarn BR, King M, Balko SU, Svenson LW, et al. Recent epidemiologic trends of diabetes mellitus among status Aboriginal adults. CMAJ. 2011;183(12):E803–8.PubMedPubMedCentralCrossRef
25.
Harris SB, Gittelsohn J, Hanley A, Barnie A, Wolever TM, Gao J, et al. The prevalence of NIDDM and associated risk factors in native Canadians. Diabetes Care. 1997;20(2):185–7.PubMedCrossRef
26.
Delisle HF, Ekoé JM. Prevalence of non-insulin-dependent diabetes mellitus and impaired glucose tolerance in two Algonquin communities in Quebec. CMAJ. 1993;148(1):41–7.PubMedPubMedCentral
27.
Ley SH, Harris SB, Mamakeesick M, Noon T, Fiddler E, Gittelsohn J, et al. Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community. CMAJ: Can Med Assoc J = J Assoc Med Can. 2009;180(6):617–24.CrossRef
28.
Martens P, Bartlett J, Burland E, Prior H, Burchill C, Huq S, et al. Métis health status and healthcare utilization in Manitoba: a population-based study. Winnipeg: Manitoba Centre for Health Policy; 2010.
29.
Shah BR, Cauch-Dudek K, Pigeau L. Diabetes prevalence and care in the Métis population of Ontario, Canada. Diabetes Care. 2011;34(12):2555–6.PubMedPubMedCentralCrossRef
30.
Aboriginal Peoples Survey, 2006: Inuit health and social conditions: supporting data tables. In: Statistics Canada, editor. Ottawa: Statistics Canada; 2008.
31.
Egeland GM, Cao Z, Young TK. Hypertriglyceridemic-waist phenotype and glucose intolerance among Canadian Inuit: the international polar year Inuit health survey for adults 2007–2008. CMAJ. 2011;183:E553–8.PubMedPubMedCentralCrossRef
32.
Dean HJ, Mundy RL, Moffatt M. Non-insulin dependent diabetes mellitus in Indian children in Manitoba. Can Med Assoc J. 1992;147:52–7.
33.
Harris SB, Perkins B, Whalen-Brough E. Non-insulin dependent diabetes mellitus among First Nations children: new entity among First Nations people of northwestern Ontario. Can Fam Phys. 1996;42:869–76.
34.
Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics. 2005;116(2):473–80.PubMedCrossRef
35.
Zdravkovic V, Daneman D, Hamilton J. Presentation and course of Type 2 diabetes in youth in a large multi-ethnic city. Diabet Med. 2004;21(10):1144–8.PubMedCrossRef
36.
Hanley AJ, Harris SB, Gittelsohn J, Wolever TM, Saksvig B, Zinman B. Overweight among children and adolescents in a Native Canadian community: prevalence and associated factors. Am J Clin Nutr. 2000;71(3):693–700.PubMed
37.
Willows ND, Johnson MS, Ball GD. Prevalence estimates of overweight and obesity in Cree preschool children in northern Quebec according to international and US reference criteria. Am J Public Health. 2007;97(2):311–6.PubMedPubMedCentralCrossRef
38.
Bernard L, Lavallee C, Gray-Donald K, Delisle H. Overweight in Cree schoolchildren and adolescents associated with diet, low physical activity, and high television viewing. J Am Diet Assoc. 1995;95(7):800–2.PubMedCrossRef
39.
Willows ND. Overweight in Aboriginal children: prevalence, implications, and solutions. J Aborig Health. 2005;2:76–85.
40.
Amed S, Dean HJ, Panagiotopoulos C, Sellers EA, Hadjiyannakis S, Laubscher TA, et al. Type 2 diabetes, medication-induced diabetes, and monogenic diabetes in Canadian children: a prospective national surveillance study. Diabetes Care. 2010;33(4):786–91.PubMedPubMedCentralCrossRef
41.
Amed S, Hamilton JK, Sellers EA, Panagiotopoulos C, Hadjiyannakis S, Shah BR, et al. Differing clinical features in Aboriginal vs. non-Aboriginal children presenting with type 2 diabetes. Pediatr Diabetes. 2012;13(6):470–5.PubMedCrossRef
42.
Silverman BL, Rizzo TA, Cho NH, Metzger BE. Long-term effects of the intrauterine environment. The Northwestern University Diabetes in Pregnancy Center. Diabetes Care. 1998;21 Suppl 2:B142–9.PubMed
43.
Druet C, Ong KK. Early childhood predictors of adult body composition. Best Pract Res Clin Endocrinol Metab. 2008;22(3):489–502.PubMedCrossRef
44.
Hanley AJ, Harris SB, Mamakeesick M, Goodwin K, Fiddler E, Hegele RA, et al. Complications of Type 2 diabetes among Aboriginal Canadians: prevalence and associated risk factors. Diabetes Care. 2005;28(8):2054–7.PubMedCrossRef
45.
Dyck RF, Tan L. Rates and outcomes of diabetic end-stage renal disease among registered native people in Saskatchewan. CMAJ. 1994;150(2):203–8.PubMedPubMedCentral
46.
McIntyre I, Boughen C, Trepman E, Embil JM. Foot and ankle problems of Aboriginal and non-Aboriginal diabetic patients with end-stage renal disease. Foot Ankle Int. 2007;28(6):674–86.PubMedCrossRef
47.
Maberley D, Walker H, Koushik A, Cruess A. Screening for diabetic retinopathy in James Bay, Ontario: a cost-effectiveness analysis. CMAJ. 2003;168(2):160–4.PubMedPubMedCentral
48.
Ross SA, McKenna A, Mozejko S, Fick GH. Diabetic retinopathy in native and nonnative Canadians. Exp Diabetes Res. 2007;2007:76271.PubMedCrossRef
49.
Macaulay AC, Montour LT, Adelson N. Prevalence of diabetic and atherosclerotic complications among Mohawk Indians of Kahnawake, PQ. CMAJ. 1988;139:221–4.PubMedPubMedCentral
50.
Shah BR, Hux JE, Zinman B. Increasing rates of ischemic heart disease in the native population of Ontario, Canada. Arch Intern Med. 2000;160(12):1862–6.PubMedCrossRef
51.
Naqshbandi M, Harris SB, Esler JB, Antwi-Nsiah F. Global complication rates of type 2 diabetes in indigenous peoples: a comprehensive review. Diabetes Res Clin Pract. 2008;82(1):1–17.PubMedCrossRef
52.
Health Canada. Diabetes among Aboriginal people in Canada: the evidence. Ottawa: Health Canada; 2001.
53.
Martens PJ, Martin BD, O’Neil JD, MacKinnon M. Diabetes and adverse outcomes in a First Nations population: associations with healthcare access, and socioeconomic and geographical factors. Can J Diabetes. 2007;31(3):223–32.CrossRef
54.
Oster RT, Toth EL. Differences in the prevalence of diabetes risk-factors among First Nation, Métis and non-Aboriginal adults attending screening clinics in rural Alberta, Canada. Rural Remote Health. 2009;9(2):1170.PubMed
55.
Dyck RF. Mechanisms of renal disease in indigenous populations: influences at work in Canadian indigenous peoples. Nephrology. 2001;6:3–7.CrossRef
56.
Register COR. Annual report. vol. 1: dialysis and renal transplantation. Ottawa: Canadian Institute for Health Information; 2001.
57.
Yeates KE. Aboriginal patients on the road to kidney transplantation: is residence location a barrier? Kidney Int. 2006;70(5):826–8.PubMedCrossRef
58.
Tonelli M, Hemmelgarn B, Kim AK, Bertazzon S, Klarenbach S, Manns B, et al. Association between residence location and likelihood of kidney transplantation in Aboriginal patients treated with dialysis in Canada. Kidney Int. 2006;70(5):924–30.PubMedCrossRef
59.
Tonelli M, Chou S, Gourishankar S, Jhangri GS, Bradley J, Hemmelgarn B, et al. Wait-listing for kidney transplantation among Aboriginal hemodialysis patients. Am J Kidney Dis. 2005;46(6):1117–23.PubMedCrossRef
60.
Tonelli M, Hemmelgarn B, Manns B, Davison S, Bohm C, Gourishankar S, et al. Use and outcomes of peritoneal dialysis among Aboriginal people in Canada. J Am Soc Nephrol. 2005;16(2):482–8.PubMedCrossRef
61.
Statistics Canada. Canadian community health survey, nutrition: general health component, public use microdata file guide. Ottawa: Health Statistics Division, Statistics Canada; 2005.
62.
Katzmarzyk PT. Obesity and physical activity among Aboriginal Canadians. Obesity (Silver Spring). 2008;16(1):184–90.CrossRef
63.
Charbonneau-Roberts G, Saudny-Unterberger H, Kuhnlein HV, Egeland GM. Body mass index may overestimate the prevalence of overweight and obesity among the Inuitd. Int J Circumpolar Health. 2005;64(4):163–9.PubMed
64.
Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86(5):1930–5.PubMedCrossRef
65.
Warne DK, Charles MA, Hanson RL, Jacobsson LT, McCance DR, Knowler WC, et al. Comparison of body size measurements as predictors of NIDDM in Pima Indians. Diabetes Care. 1995;18(4):435–9.PubMedCrossRef
66.
Ashwell M, Gunn P, Gibson S. Waist-to-height ratio is a better screening tool than waist circumference and BMI for adult cardiometabolic risk factors: systematic review and meta-analysis. Obes Rev Off J Int Assoc Study Obes. 2012;13(3):275–86.
67.
Willi C, Bodenmann P, Ghali WA, Faris PD, Cornuz J. Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis. JAMA: J Am Med Assoc U S. 2007;298:2654–64.CrossRef
68.
Wallace S. Inuit health: selected findings from the 2012 Aboriginal peoples survey. Statistics Canada. 2014 89-653-X-003.
69.
Daniel M, Cargo MD. Association between smoking, insulin resistance and beta-cell function in a North-western First Nation. Diabet Med. 2004;21(2):188–93.PubMedCrossRef
70.
Ley SH, Hegele RA, Harris SB, Mamakeesick M, Cao H, Connelly PW, et al. HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study. BMC Med Genet. 2011;12:1.PubMedPubMedCentralCrossRef
71.
Wolever TM. Dietary carbohydrates and insulin action in humans. Br J Nutr. 2000;83 Suppl 1:S97–102.PubMed
72.
Wolfram T, Ismail-Beigi F. Efficacy of high-fiber diets in the management of type 2 diabetes mellitus. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. 2011;17(1):132–42.
73.
Tunnicliffe JM, Shearer J. Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators. Appl Phys Nutr Metab = Physiol Appl Nutr Metab. 2008;33(6):1290–300.CrossRef
74.
Tong X, Dong JY, Wu ZW, Li W, Qin LQ. Dairy consumption and risk of type 2 diabetes mellitus: a meta-analysis of cohort studies. Eur J Clin Nutr. 2011;65(9):1027–31.
75.
Malik VS, Schulze MB, Hu FBCPCN. Intake of sugar-sweetened beverages and weight gain: a systematic review. Am J Clin Nutr. 2006;84:274–88.PubMedPubMedCentral
76.
Bray GA, Popkin BM. Dietary fat intake does affect obesity! Am J Clin Nutr. 1998;68(6):1157–73.PubMed
77.
Mansuri S, Badawi A, Kayaniyil S, Cole DE, Harris SB, Mamakeesick M, et al. Associations of circulating 25(OH)D with cardiometabolic disorders underlying type 2 diabetes mellitus in an Aboriginal Canadian community. Diabetes Res Clin Pract. 2015;109(2):440–9.
78.
Kuhnlein HV, Receveur O, Soueida R, Berti PR. Unique patterns of dietary adequacy in three cultures of Canadian Arctic indigenous peoples. Public Health Nutr. 2008;11(4):349–60.PubMedCrossRef
79.
Johnson-Down L, Egeland GM. Adequate nutrient intakes are associated with traditional food consumption in nunavut Inuit children aged 3–5 years. J Nutr. 2010;140(7):1311–6.
80.
Receveur O, Kuhnlein HV. Benefits of traditional food in Dene/Métis communities. Int J Circumpolar Health. 1998;57 Suppl 1:219–21.PubMed
81.
Kuhnlein HV, Receveur O, Soueida R, Egeland GM. Arctic indigenous peoples experience the nutrition transition with changing dietary patterns and obesity. J Nutr. 2004;134(6):1447–53.PubMed
82.
Sharma S, Cao X, Roache C, Buchan A, Reid R, Gittelsohn J. Assessing dietary intake in a population undergoing a rapid transition in diet and lifestyle: the Arctic Inuit in Nunavut, Canada. Br J Nutr. 2010;103(5):749–59.
83.
Wolever TMS, Hamad S, Gittelsohn J, Hanley AJG, Logan A, Harris SB, et al. Nutrient intake and food use in an Ojibwa-Cree community in Northern Ontario assessed by 24h dietary recall. Nutr Res. 1997;17:603–18.CrossRef
84.
Gittelsohn J, Wolever TM, Harris SB, Harris-Giraldo R, Hanley AJ, Zinman B. Specific patterns of food consumption and preparation are associated with diabetes and obesity in a Native Canadian community. J Nutr. 1998;128:541–7.PubMed
85.
Batal M, Gray-Donald K, Kuhnlein HV, Receveur O. Estimation of traditional food intake in indigenous communities in Denendeh and the Yukon. Int J Circumpolar Health. 2005;64(1):46–54.PubMedCrossRef
86.
Receveur O, Boulay M, Kuhnlein HV. Decreasing traditional food use affects diet quality for adult Dene/Métis in 16 communities of the Canadian Northwest Territories. J Nutr. 1997;127(11):2179–86.PubMed
87.
Wolever TM, Hamad S, Gittelsohn J, Gao J, Hanley AJ, Harris SB, et al. Low dietary fiber and high protein intakes associated with newly diagnosed diabetes in a remote aboriginal community. Am J Clin Nutr. 1997;66(6):1470–4.PubMed
88.
Costacou T, Mayer-Davis EJ. Nutrition and prevention of type 2 diabetes. Annu Rev Nutr. 2003;23:147–70.PubMedCrossRef
89.
Schulze MB, Hu FB. Primary prevention of diabetes: what can be done and how much can be prevented? Annu Rev Public Health. 2005;26:445–67.PubMedCrossRef
90.
Parillo M, Riccardi G. Diet composition and the risk of type 2 diabetes: epidemiological and clinical evidence. Br J Nutr. 2004;92(1):7–19.PubMedCrossRef
91.
Adler AI, Boyko EJ, Schraer CD, Murphy NJ. Lower prevalence of impaired glucose tolerance and diabetes associated with daily seal oil or salmon consumption among Alaska Natives. Diabetes Care. 1994;17(12):1498–501.PubMedCrossRef
92.
Johnson-Down L, Labonte ME, Martin ID, Tsuji LJ, Nieboer E, Dewailly E, et al. Quality of diet is associated with insulin resistance in the Cree (Eeyouch) indigenous population of northern Quebec. Nutr Metab Cardiovasc Dis. 2015;25(1):85–92
93.
Willows ND, Veugelers P, Raine K, Kuhle S. Prevalence and sociodemographic risk factors related to household food security in Aboriginal peoples in Canada. Public Health Nutr. 2009;12(8):1150–6.PubMedCrossRef
94.
Office of Nutrition Policy and Promotion and Health Canada. Canadian Community Health Survey Cycle 2.2, Nutrition (2004): Income-Related Household Food Security in Canada. Health Canada: Ottawa, ON, 2007.
95.
Power EM. Conceptualizing food security or aboriginal people in Canada. Can J Public Health. 2008;99:95–7.PubMed
96.
Lambden J, Receveur O, Marshall J, Kuhnlein HV. Traditional and market food access in Arctic Canada is affected by economic factors. Int J Circumpolar Health. 2006;65(4):331–40.PubMedCrossRef
97.
Guyot M, Dickson C, Paci M, Furgal F, Chan HM. Local observations of climate change and impacts on traditional food security in two northern Aboriginal communities. Int J Circumpolar Health. 2006;65:403–15.PubMedCrossRef
98.
Kuhnlein HV, Chan HM. Environment and contaminants in traditional food systems of northern indigenous peoples. Annu Rev Nutr. 2000;20:595–626.PubMedCrossRef
99.
Hu FB, Manson JE, Stampfer MJ, Colditz G, Liu S, Solomon CG, et al. Diet, lifestyle, and the risk of type 2 diabetes mellitus in women. N Engl J Med. 2001;345(11):790–7.PubMedCrossRef
100.
Hu FB, Li TY, Colditz GA, Willett WC, Manson JE. Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA. 2003;289(14):1785–91.PubMedCrossRef
101.
Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement executive summary. Diabetes Care. 2010;33(12):2692–6.PubMedPubMedCentralCrossRef
102.
Jeon CY, Lokken RP, Hu FB, van Dam RM. Physical activity of moderate intensity and risk of type 2 diabetes: a systematic review. Diabetes Care. 2007;30(3):744–52.PubMedCrossRef
103.
Reading J. Confronting the growing crisis of cardiovascular disease and heart health among Aboriginal peoples in Canada. Can J Cardiol. 2015;31(9):1077–80.PubMedCrossRef
104.
Kriska AM, Hanley AJ, Harris SB, Zinman B. Physical activity, physical fitness, and insulin and glucose concentrations in an isolated Native Canadian population experiencing rapid lifestyle change. Diabetes Care. 2001;24(10):1787–92.PubMedCrossRef
105.
Horn OK, Paradis G, Potvin L, Macaulay AC, Desrosiers S. Correlates and predictors of adiposity among Mohawk children. Prev Med. 2001;33(4):274–81.PubMedCrossRef
106.
Hegele RA. Genes and environment in type 2 diabetes and atherosclerosis in aboriginal Canadians. Curr Atheroscler Rep. 2001;3(3):216–21.PubMedCrossRef
107.
Group HSCR, Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, et al. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008;358(19):1991–2002.CrossRef
108.
Boney CM, Verma A, Tucker R, Vohr BR. Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics. 2005;115(3):e290–6.PubMedCrossRef
109.
Dyck R, Klomp H, Tan LK, Turnell RW, Boctor MA. A comparison of rates, risk factors, and outcomes of gestational diabetes between aboriginal and non-aboriginal women in the Saskatoon health district. Diabetes Care. 2002;25(3):487–93.PubMedCrossRef
110.
Munroe M, Shah CP, Badgley R, Bain HW. Birth weight, length, head circumference and bilirubin level in Indian newborns in the Sioux Lookout Zone, northwestern Ontario. Can Med Assoc J. 1984;131(5):453–6.PubMedPubMedCentral
111.
Thomson M. Heavy birth weight in Native Indians of British Columbia. Can J Public Health. 1990;81(6):443–6.PubMed
112.
Rodrigues S, Robinson EJ, Kramer MS, Gray-Donald K. High rates of infant macrosomia: a comparison of a Canadian native and a non-native population. J Nutr. 2000;130(4):806–12.PubMed
113.
Luo ZC, Wilkins R, Heaman M, Smylie J, Martens PJ, McHugh NG, et al. Birth outcomes and infant mortality among First Nations Inuit, and non-indigenous women by northern versus southern residence, Quebec. J Epidemiol Community Health. 2012;66(4):328–33.PubMedCrossRef
114.
Willows ND, Sanou D, Bell RC. Assessment of Canadian Cree infants’ birth size using the WHO Child Growth Standards. Am J Hum Biol. 2011;23(1):126–31.PubMedCrossRef
115.
Wassimi S, Wilkins R, McHugh NG, Xiao L, Simonet F, Luo ZC. Association of macrosomia with perinatal and postneonatal mortality among First Nations people in Quebec. CMAJ. 2011;183(3):322–6.PubMedPubMedCentralCrossRef
116.
Kirmayer LJ, Brass GM, Tait CL. The mental health of Aboriginal peoples: transformations of identity and community. Can J Psychiatry. 2000;45(7):607–16.PubMed
117.
Tjepkema M. The health of the off-reserve Aboriginal population. In: Canada S, editor. Supplement to health reports. Ottawa: Statistics Canada; 2002.
118.
Health Canada. Rural health in rural hands: strategic directions for rural, remote, northern and aboriginal communities. Health Canada, 2002. [cited 2000 July 20]. Available from http://​publications.​gc.​ca/​pub?​id=​9.​689374&​sl=​0.
119.
Carriere G, Garner R, Sanmartin C, LHAD. Acute-care hospitalizations and aboriginal identity in Canada, 2001/2001. Ottawa: Statistics Canada; 2010.
120.
Imamura M, Maeda S. Genetics of type 2 diabetes: the GWAS era and future perspectives. Rev Endocr J. 2011;58(9):723–39.
121.
Billings LK, Florez JC. The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci. 2010;1212:59–77.PubMedPubMedCentralCrossRef
122.
Lyssenko V, Laakso M. Genetic screening for the risk of type 2 diabetes: worthless or valuable? Diabetes Care. 2013;36 Suppl 2:S120–6.PubMedPubMedCentralCrossRef
123.
Medici F, Hawa M, Ianari A, Pyke DA, Leslie RD. Concordance rate for type II diabetes mellitus in monozygotic twins: actuarial analysis. Diabetologia. 1999;42(2):146–50.PubMedCrossRef
124.
Chen R, Corona E, Sikora M, Dudley JT, Morgan AA, Moreno-Estrada A, et al. Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases. PLoS Genet. 2012;8(4):e1002621.PubMedPubMedCentralCrossRef
125.
Neel JV. Diabetes mellitus: a “thrifty” genotype rendered detrimental by “progress”? Am J Hum Genet. 1962;14:353–62.PubMedPubMedCentral
126.
Hegele RA, Cao H, Harris SB, Hanley AJ, Zinman B. The hepatic nuclear factor-1alpha G319S variant is associated with early-onset type 2 diabetes in Canadian Oji-Cree. J Clin Endocrinol Metab. 1999;84(3):1077–82.PubMed
127.
Pollex RL, Hanley AJ, Zinman B, Harris SB, Hegele RA. Clinical and genetic associations with hypertriglyceridemic waist in a Canadian aboriginal population. Int J Obes (2005). 2006;30(3):484–91.
128.
Health Canada. Fact sheet- First Nations and Inuit health branch health Canada website 2008 (updated 2008; cited 26 Feb 2016). Available from http://​www.​hc-sc.​gc.​ca/​ahc-asc/​branch-dirgen/​fnihb-dgspni/​fact-fiche-eng.​php.
129.
Health Canada. Aboriginal diabetes initiative 2010–2015 (updated 2011; cited 26 Feb 2016) 2016. Available from http://​www.​hc-sc.​gc.​ca/​fniah-spnia/​pubs/​diseases-maladies/​_​diabete/​2010-2015-frame-cadre/​indexeng.​php.
130.
Minore B, Boone M, Katt M, Kinch P, Birch S. Facilitating the continuity of care for first nation clients within a regional context. 2001.
131.
King M, Smith A, Gracey M. Indigenous health part 2: the underlying causes of the health gap. Lancet. 2009;374(9683):76–85.PubMedCrossRef
132.
Shah BR, Gunraj N, Hux JE. Markers of access to and quality of primary care for aboriginal people in Ontario, Canada. Am J Public Health. 2003;93(5):798–802.PubMedPubMedCentralCrossRef
133.
Lavoie JG, Forget EL, Prakash T, Dahl M, Martens P, O’Neil JD. Have investments in on-reserve health services and initiatives promoting community control improved First Nations’ health in Manitoba? Soc Sci Med. 2010;71(4):717–24.PubMedCrossRef
134.
Gracey M, King M. Indigenous health part 1: determinants and disease patterns. Lancet. 2009;374(9683):65–75.PubMedCrossRef
135.
Bramley D, Hebert P, Tuzzio L, Chassin M. Disparities in indigenous health: a cross-country comparison between New Zealand and the United States. Am J Public Health. 2005;95(5):844–50.PubMedPubMedCentralCrossRef
136.
Bhattacharyya OK, Rasooly IR, Naqshbandi M, Estey EA, Esler J, Toth E, et al. Challenges to the provision of diabetes care in first nations communities: results from a national survey of healthcare providers in Canada. BMC Health Serv Res. 2011;11:283.PubMedPubMedCentralCrossRef
137.
Pohar SL, Johnson JA. Health care utilization and costs in Saskatchewan’s registered Indian population with diabetes. BMC Health Serv Res. 2007;7:126.PubMedPubMedCentralCrossRef
138.
FORGE AHEAD program description London, ON: the national diabetes management strategy. 2011 [cited 7 Mar 2016]. Available from http://​tndms.​ca/​forgeahead/​index.​html.
139.
Glazier RH, Bajcar J, Kennie NR, Willson K. A systematic review of interventions to improve diabetes care in socially disadvantaged populations. Diabetes Care. 2006;29(7):1675–88.PubMedCrossRef
140.
Kakekagumick KE, Naqshbandi Hayward M, Harris SB, Saksvig B, Gittelsohn J, Manokeesic G, et al. Sandy lake health and diabetes project: a community-based intervention targeting type 2 diabetes and its risk factors in a first nations community. Front Endocrinol. 2013;4:170.
141.
Saksvig BI, Gittelsohn J, Harris SB, Hanley AJ, Valente TW, Zinman B. A pilot school-based healthy eating and physical activity intervention improves diet, food knowledge, and self-efficacy for native Canadian children. J Nutr. 2005;135(10):2392–8.PubMed
142.
Macaulay AC, Paradis G, Potvin L, Cross EJ, Saad-Haddad C, McComber A, et al. The Kahnawake Schools Diabetes Prevention Project: intervention, evaluation, and baseline results of a diabetes primary prevention program with a native community in Canada. Prev Med. 1997;26(6):779–90.PubMedCrossRef
143.
Paradis G, Levesque L, Macaulay AC, Cargo M, McComber A, Kirby R, et al. Impact of a diabetes prevention program on body size, physical activity, and diet among Kanien’keha:ka (Mohawk) children 6 to 11 years old: 8-year results from the Kahnawake Schools Diabetes Prevention Project. Pediatrics. 2005;115(2):333–9.PubMedCrossRef
144.
Tomlin D, Naylor PJ, McKay H, Zorzi A, Mitchell M, Panagiotopoulos C. The impact of Action Schools! BC on the health of Aboriginal children and youth living in rural and remote communities in British Columbia. Int J Circumpolar Health. 2012;71:17999.PubMedCrossRef

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