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Horm Metab Res 2003; 35(10): 625-627
DOI: 10.1055/s-2003-43511
Short Communication
© Georg Thieme Verlag Stuttgart · New York

Fatty Acid Binding Protein Gene 2 Polymorphism Is Not Associated with Diabetic Retinopathy in Japanese Type 2 Diabetic Patients

K.  Yoshioka1 , T.  Yoshida2 , Y.  Takakura2 , T.  Umekawa2 , A.  Kogure2 , H.  Toda3 , T.  Yoshikawa4
  • 1Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, Moriguchi, Japan
  • 2Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto
  • 3Sakazaki Clinic, Kyoto, Japan
  • 4Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto
Further Information

Publication History

Received 9 April 2003

Accepted after revision 16 June 2003

Publication Date:
07 November 2003 (online)

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Introduction

The development of diabetic retinopathy shows marked variations among individuals. Not only metabolic control, but also genetic factors may contribute to the development of diabetic retinopathy. Insulin resistance is now recognized as an independent risk factor for macroangiopathy in type 2 diabetes [1]. There is one report on the association between insulin resistance and diabetic retinopathy [2]. Fatty acid binding protein 2 (FABP2) is an intracellular protein expressed only in the intestine and acts as fatty acid absorption and metabolism [3]. An association between substitution of alanine to threonine at codon 54 of the FABP2 gene (Ala54Thr) and insulin resistance, presumably by increasing the absorption and oxidation of fatty acids, has been demonstrated [4] [5]. In addition, a putative association between FABP2 gene polymorphism and macroangiopathy has been described in diabetes [6]. However, there has been no report on any association between the polymorphism of the FABP2 gene and diabetic microangiopathy. We therefore examined the association between FABP2 gene polymorphism and diabetic retinopathy in Japanese type 2 diabetic patients.

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K. Yoshioka, M. D.

Department of Diabetes and Endocrinology, Matsushita Memorial Hospital ·

5-55, Sotojima-cho · Moriguchi · Osaka 570-8540 · Japan

Phone: + 81 (6) 6992 1231

Fax: + 81 (6) 6992 4845

Email: yoshik@mue.biglobe.ne.jp

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