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Am J Perinatol 2010; 27(5): 367-373
DOI: 10.1055/s-0029-1243310
© Thieme Medical Publishers

Early Versus Delayed Minimal Enteral Feeding and Risk for Necrotizing Enterocolitis in Preterm Growth-Restricted Infants with Abnormal Antenatal Doppler Results

Paraskevi Karagianni1 , Despina D. Briana2 , George Mitsiakos1 , Anestis Elias1 , Theodoros Theodoridis3 , Elias Chatziioannidis1 , Maria Kyriakidou1 , Nikolaos Nikolaidis1
  • 12nd NICU and Neonatology Department, Aristotle University of Thessaloniki, G.P.N. Papageorgiou, Thessaloniki, Greece
  • 2Honorary Clinical Fellow, Newborn Unit, King's College Hospital, London, United Kingdom
  • 31st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, G.P.N. Papageorgiou, Thessaloniki, Greece
Further Information

Publication History

Publication Date:
10 December 2009 (online)

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ABSTRACT

We studied the effect of early (≤5 days) versus delayed (≥6 days) initiation of minimal enteral feeding (MEF) on the incidence of necrotizing enterocolitis (NEC) and feeding intolerance in preterm infants with intrauterine growth restriction (IUGR) and abnormal antenatal Doppler results. We performed a randomized, nonblinded pilot trial of infants receiving early or delayed MEF in addition to parenteral feeding within 48 hours of life. Demographic data, maternal preeclampsia, antenatal steroid exposure, Doppler studies, as well as cases of NEC and feeding intolerance were all recorded. Of the 84 infants enrolled, 81 completed the study: 40 received early (median age: 2 days, range: 1 to 5 days) and 41 delayed (median age: 7 days, range: 6 to 14 days) MEF. The incidence of NEC and feeding intolerance was not significantly different between groups (p = 0.353 and p = 0.533, respectively). Birth weight was an independent risk factor for NEC in both groups. Early MEF of preterm infants with IUGR and abnormal antenatal Doppler results may not have a significant effect on the incidence of NEC or feeding intolerance. Furthermore, birth weight seems to be an independent risk factor for the development of NEC, irrespectively of the timing of MEF introduction.

KEYWORDS

Prematurity - intrauterine growth restriction - necrotizing enterocolitis - minimal enteral feeding - Doppler

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Paraskevi KaragianniM.D. 

2nd NICU and Neonatology Department, G.P.N. Papageorgiou, Ring Road, Nea Efkarpia

56403 Thessaloniki, Greece

Email: karagpar@med.auth.gr

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