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02-06-2018 | Pregnancy | Review | Article

Caring for pregnant women whose diabetes antedates pregnancy: is there room for improvement?

Journal: Diabetologia

Authors: David A. Sacks, Denice S. Feig

Publisher: Springer Berlin Heidelberg



Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE (2014) Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract 103:137–149 CrossRefPubMed
Fong A, Serra A, Herrero T, Pan D, Ogunyemi D (2014) Pre-gestational versus gestational diabetes: a population based study on clinical and demographic differences. J Diabetes Complicat 28:29–34 CrossRefPubMed
Feig DS, Hwee J, Shah BR, Booth GL, Bierman AS, Lipscombe LL (2014) Trends in incidence of diabetes in pregnancy and serious perinatal outcomes: a large, population-based study in Ontario, Canada, 1996-2010. Diabetes Care 37:1590–1596 CrossRefPubMed
Peng TY, Ehrlich SF, Crites Y et al (2017) Trends and racial and ethnic disparities in the prevalence of pregestational type 1 and type 2 diabetes in Northern California: 1996-2014. Am J Obstet Gynecol 216:177.e1–e8 CrossRef
Fadl HE, Simmons D (2016) Trends in diabetes in pregnancy in Sweden 1998-2012. BMJ Open Diabetes Res Care 4:e000221 CrossRefPubMedPubMedCentral
Coton SJ, Nazareth I, Petersen I (2016) A cohort study of trends in the prevalence of pregestational diabetes in pregnancy recorded in UK general practice between 1995 and 2012. BMJ Open 6:e009494 CrossRefPubMedPubMedCentral
Mackin ST, Nelson SM, Kerssens JJ et al (2018) Diabetes and pregnancy: national trends over a 15 year period. Diabetologia. https://​doi.​org/​10.​1007/​s00125-017-4529-3
Murphy HR, Bell R, Cartwright C et al (2017) Improved pregnancy outcomes in women with type 1 and type 2 diabetes but substantial clinic-to-clinic variations: a prospective nationwide study. Diabetologia 60:1668–1677 CrossRefPubMedPubMedCentral
Schaefer-Graf U, Napoli A, Nolan CJ, The Diabetic Pregnancy Study Group (2018) Diabetes in pregnancy: a new decade of challenges ahead. Diabetologia https://​doi.​org/​10.​1007/​s00125-018-4545-y
Persson M, Norman M, Hanson U (2009) Obstetric and perinatal outcomes in type 1 diabetic pregnancies: a large, population-based study. Diabetes Care 32:2005–2009 CrossRefPubMedPubMedCentral
Evers IM, de Valk HW, Visser GH (2004) Risk of complications of pregnancy in women with type 1 diabetes: nationwide prospective study in the Netherlands. BMJ 328:915 CrossRefPubMedPubMedCentral
Miller E, Hare JW, Cloherty JP et al (1981) Elevated maternal hemoglobin A1c in early pregnancy and major congenital anomalies in infants of diabetic mothers. N Engl J Med 304:1331–1334 CrossRefPubMed
Mills JL, Baker L, Goldman AS (1979) Malformations in infants of diabetic mothers occur before the seventh gestational week. Implications for treatment. Diabetes 28:292–293 CrossRefPubMed
Kekalainen P, Juuti M, Walle T, Laatikainen T (2016) Pregnancy planning in type 1 diabetic women improves glycemic control and pregnancy outcomes. J Matern Fetal Neonatal Med 29:2252–2258 CrossRefPubMed
Sereika SM, Becker D, Schmitt P et al (2016) Operationalizing and examining family planning vigilance in adult women with type 1 diabetes. Diabetes Care 39:2197–2203 CrossRefPubMedPubMedCentral
Easter SR, Rosenthal EW, Morton-Eggleston E, Nour N, Tuomala R, Zera CA (2017) Disparities in care for publicly insured women with pregestational diabetes. Obstet Gynecol 130:946–952 CrossRefPubMed
Yee LM, McGuire JM, Taylor SM, Niznik CM, Simon MA (2015) “I was tired of all the sticking and poking”: identifying barriers to diabetes self-care among low-income pregnant women. J Health Care Poor Underserved 26:926–940 CrossRefPubMed
Forde R, Patelarou EE, Forbes A (2016) The experiences of prepregnancy care for women with type 2 diabetes mellitus: a meta-synthesis. Int J Womens Health 8:691–703 CrossRefPubMedPubMedCentral
Mathiesen ER, Kinsley B, Amiel SA et al (2007) Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy: a randomized trial of insulin aspart versus human insulin in 322 pregnant women. Diabetes Care 30:771–776 CrossRefPubMed
Lv S, Wang J, Xu Y (2015) Safety of insulin analogs during pregnancy: a meta-analysis. Arch Gynecol Obstet 292:749–756 CrossRefPubMed
Mathiesen ER, Hod M, Ivanisevic M et al (2012) Maternal efficacy and safety outcomes in a randomized, controlled trial comparing insulin detemir with NPH insulin in 310 pregnant women with type 1 diabetes. Diabetes Care 35:2012–2017 CrossRefPubMedPubMedCentral
Herrera KM, Rosenn BM, Foroutan J et al (2015) Randomized controlled trial of insulin detemir versus NPH for the treatment of pregnant women with diabetes. Am J Obstet Gynecol 213:426.e1-e7 CrossRef
Pollex E, Moretti ME, Koren G, Feig DS (2011) Safety of insulin glargine use in pregnancy: a systematic review and meta-analysis. Ann Pharmacother 45:9–16 CrossRefPubMed
Murphy HR, Rayman G, Lewis K et al (2008) Effectiveness of continuous glucose monitoring in pregnant women with diabetes: randomised clinical trial. BMJ 337:a1680 CrossRefPubMedPubMedCentral
Secher AL, Ringholm L, Andersen HU, Damm P, Mathiesen ER (2013) The effect of real-time continuous glucose monitoring in pregnant women with diabetes: a randomized controlled trial. Diabetes Care 36:1877–1883 CrossRefPubMedPubMedCentral
Feig DS, Donovan LE, Corcoy R et al (2017) Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial. Lancet 390:2347–2359 CrossRefPubMedPubMedCentral
Gonzalez-Romero S, Gonzalez-Molero I, Fernandez-Abellan M et al (2010) Continuous subcutaneous insulin infusion versus multiple daily injections in pregnant women with type 1 diabetes. Diabetes Technol Ther 12:263–269 CrossRefPubMed
Kallas-Koeman MM, Kong JM, Klinke JA et al (2014) Insulin pump use in pregnancy is associated with lower HbA 1c without increasing the rate of severe hypoglycaemia or diabetic ketoacidosis in women with type 1 diabetes. Diabotologia 57:681–689 CrossRef
Stewart ZA, Wilinska ME, Hartnell S et al (2016) Closed-loop insulin delivery during pregnancy in women with type 1 diabetes. N Engl J Med 375:644–654 CrossRefPubMed
Feig DS, Murphy K, Asztalos E et al (2016) Metformin in women with type 2 diabetes in pregnancy (MiTy): a multi-center randomized controlled trial. BMC Pregnancy Childbirth 16:173 CrossRefPubMedPubMedCentral
Invokana [package insert] (2017) Janssen Pharmaceuticals, Titusville, NJ. Available from www.​janssenlabels.​com/​package-insert/​product-monograph/​prescribing-information/​INVOKANA-pi.​pdf. Accessed 26 January 2018
Victoza [package insert] (2017). Novo Nordisk Canada, Mississauga, ON. Available from www.​novonordisk.​ca/​content/​dam/​Canada/​AFFILIATE/​www-novonordisk-ca/​OurProducts/​PDF/​victoza-product-monograph.​pdf. Accessed 26 January 2018
Lau Y, Htun TP, Wong SN, Tam WS, Klainin-Yobas P (2016) Efficacy of internet-based self-monitoring interventions on maternal and neonatal outcomes in perinatal diabetic women: a systematic review and meta-analysis. J Med Internet Res 18:e220 CrossRefPubMedPubMedCentral
Raman P, Shepherd E, Dowswell T, Middleton P, Crowther CA (2017). Different methods and settings for glucose monitoring for gestational diabetes during pregnancy. Cochrane Database Syst Rev, Issue 10, Art. no.:CD011069
Ming WK, Mackillop LH, Farmer AJ et al (2016) Telemedicine technologies for diabetes in pregnancy: a systematic review and meta-analysis. J Med Internet Res 18:e290 CrossRefPubMedPubMedCentral
(1990) Diabetes care and research in Europe: the Saint Vincent declaration. Diabet Med 7:360

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